Ginsenoside Rf, a glycoside of protopanaxatriol from Panax ginseng, is shown to be a biologically active saponin found to regulate lipoprotein metabolism. Mechanistic studies report that this regulation is done via altering of peroxisome proliferator-activated receptor α (PPARα)-mediated pathways. PPARα has demonstrated the ability to regulate C-III mRNA and basal levels of hepatic apoA-I (apolipoprotein A-I) which affect lipoprotein metabolism. Additional experiments have also observed this Ginsenoside Rf's ability to inhibit Ca2+ channels in mammalian sensory neurons in vitro. A glycoside found to mediate lipoprotein metabolism
1.Ren Rongfan, Li Hongli, Jiang Qing, Wang Xing, Chen David Da Yong. (2023) Characterization of ginsenoside structural isomers from mixtures using in situ methylation with direct analysis in real-time ionization tandem mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (5):(887-897). [PMID:36571591]
References
1.Ren Rongfan, Li Hongli, Jiang Qing, Wang Xing, Chen David Da Yong. (2023) Characterization of ginsenoside structural isomers from mixtures using in situ methylation with direct analysis in real-time ionization tandem mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (5):(887-897). [PMID:36571591]
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