| 1. Vullo D, Franchi M, Gallori E, Pastorek J, Scozzafava A, Pastorekova S, Supuran CT.. (2003) Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.. Bioorg Med Chem Lett, 13 (6): (1005-1009). [PMID:12643899] [10.1016/s0960-894x(03)00091-x] |
| 2. Abbate F, Casini A, Owa T, Scozzafava A, Supuran CT.. (2004) Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.. Bioorg Med Chem Lett, 14 (1): (217-223). [PMID:14684331] [10.1016/j.bmcl.2003.09.062] |
| 3. Antonaroli S, Bianco A, Brufani M, Cellai L, Lo Baido G, Potier E, Bonomi L, Perfetti S, Fiaschi AI, Segre G.. (1992) Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.. J Med Chem, 35 (14): (2697-2703). [PMID:1635066] [10.1021/jm00092a021] |
| 4. Garaj V, Puccetti L, Fasolis G, Winum JY, Montero JL, Scozzafava A, Vullo D, Innocenti A, Supuran CT. (2004) Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.. Bioorg Med Chem Lett, 14 (21): (5427-33). [PMID:15454239] [10.1021/op500134e] |
| 5. Pacchiano F, Carta F, McDonald PC, Lou Y, Vullo D, Scozzafava A, Dedhar S, Supuran CT. (2011) Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.. J Med Chem, 54 (6): (1896-902). [PMID:21361354] [10.1021/op500134e] |
| 6. Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L et al.. (2019) Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.. J Med Chem, 62 (15): (7233-7249). [PMID:31287314] [10.1021/op500134e] |
| 7. Anna Di Fiore,Giuseppina De Simone,Valeria Menchise,Carlo Pedone,Angela Casini,Andrea Scozzafava,Claudiu T Supuran. (2005-03-23) Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II.. Bioorganic & medicinal chemistry letters, 15 ((7)): (1937-1942). [PMID:15780637] |
| 8. Isao Nishimori,Saburo Onishi,Daniela Vullo,Alessio Innocenti,Andrea Scozzafava,Claudiu T Supuran. (2007-05-15) Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.. Bioorganic & medicinal chemistry, 15 ((15)): (5351-5357). [PMID:17499996] |
| 9. Tiphaine Rogez-Florent,Samuel Meignan,Catherine Foulon,Perrine Six,Abigaëlle Gros,Christine Bal-Mahieu,Claudiu T Supuran,Andrea Scozzafava,Raphaël Frédérick,Bernard Masereel,Patrick Depreux,Amélie Lansiaux,Jean-François Goossens,Sébastien Gluszok,Laurence Goossens. (2012-11-22) New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.. Bioorganic & medicinal chemistry, 21 ((6)): (1451-1464). [PMID:23168081] |
| 10. T Abdülkadir Coban,Sükrü Beydemir,Ilhami Gülcin,Ilhami Gücin,Deniz Ekinci,Alessio Innocenti,Daniela Vullo,Claudiu T Supuran. (2009-07-29) Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.. Bioorganic & medicinal chemistry, 17 ((16)): (5791-5795). [PMID:19635671] |
| 11. Pastorekova S, Casini A, Scozzafava A, Vullo D, Pastorek J, Supuran CT.. (2004) Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.. Bioorg Med Chem Lett, 14 (4): (869-873). [PMID:15012984] [10.1016/j.bmcl.2003.12.029] |
| 12. Weber A, Casini A, Heine A, Kuhn D, Supuran CT, Scozzafava A, Klebe G.. (2004) Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.. J Med Chem, 47 (3): (550-557). [PMID:14736236] [10.1021/jm030912m] |
| 13. Puccetti L, Fasolis G, Cecchi A, Winum JY, Gamberi A, Montero JL, Scozzafava A, Supuran CT.. (2005) Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.. Bioorg Med Chem Lett, 15 (9): (2359-2364). [PMID:15837325] [10.1016/j.bmcl.2005.02.087] |
| 14. Cecchi A, Taylor SD, Liu Y, Hill B, Vullo D, Scozzafava A, Supuran CT.. (2005) Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.. Bioorg Med Chem Lett, 15 (23): (5192-5196). [PMID:16203142] [10.1016/j.bmcl.2005.08.102] |
| 15. Temperini C, Innocenti A, Guerri A, Scozzafava A, Rusconi S, Supuran CT.. (2007) Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.. Bioorg Med Chem Lett, 17 (8): (2210-2215). [PMID:17314045] [10.1016/j.bmcl.2007.01.113] |
| 16. Saczewski F, Innocenti A, Sławiński J, Kornicka A, Brzozowski Z, Pomarnacka E, Scozzafava A, Temperini C, Supuran CT.. (2008) Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.. Bioorg Med Chem, 16 (7): (3933-3940). [PMID:18242998] [10.1016/j.bmc.2008.01.034] |
| 17. Gitto R, Ferro S, Agnello S, De Luca L, De Sarro G, Russo E, Vullo D, Supuran CT, Chimirri A.. (2009) Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.. Bioorg Med Chem, 17 (10): (3659-3664). [PMID:19398204] [10.1016/j.bmc.2009.03.066] |
| 18. Parkkila S, Innocenti A, Kallio H, Hilvo M, Scozzafava A, Supuran CT.. (2009) The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.. Bioorg Med Chem Lett, 19 (15): (4102-4106). [PMID:19527930] [10.1016/j.bmcl.2009.06.002] |
| 19. Gitto R, Agnello S, Ferro S, De Luca L, Vullo D, Brynda J, Mader P, Supuran CT, Chimirri A.. (2010) Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.. J Med Chem, 53 (6): (2401-2408). [PMID:20170095] [10.1021/jm9014026] |
| 20. Wagner J, Avvaru BS, Robbins AH, Scozzafava A, Supuran CT, McKenna R.. (2010) Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.. Bioorg Med Chem, 18 (14): (4873-4878). [PMID:20598552] [10.1016/j.bmc.2010.06.028] |
| 21. Marques SM, Enyedy EA, Supuran CT, Krupenko NI, Krupenko SA, Santos MA.. (2010) Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity.. Bioorg Med Chem, 18 (14): (5081-5089). [PMID:20580561] [10.1016/j.bmc.2010.05.072] |
| 22. Mincione F, Benedini F, Biondi S, Cecchi A, Temperini C, Formicola G, Pacileo I, Scozzafava A, Masini E, Supuran CT.. (2011) Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.. Bioorg Med Chem Lett, 21 (11): (3216-3221). [PMID:21549597] [10.1016/j.bmcl.2011.04.046] |
| 23. Touisni N, Maresca A, McDonald PC, Lou Y, Scozzafava A, Dedhar S, Winum JY, Supuran CT.. (2011) Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.. J Med Chem, 54 (24): (8271-8277). [PMID:22077347] [10.1021/jm200983e] |
| 24. Carta F, Aggarwal M, Maresca A, Scozzafava A, McKenna R, Masini E, Supuran CT.. (2012) Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.. J Med Chem, 55 (4): (1721-1730). [PMID:22276570] [10.1021/jm300031j] |
| 25. Sechi M, Innocenti A, Pala N, Rogolino D, Carcelli M, Scozzafava A, Supuran CT.. (2012) Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.. Bioorg Med Chem Lett, 22 (18): (5801-5806). [PMID:22901388] [10.1016/j.bmcl.2012.07.094] |
| 26. Gieling RG, Babur M, Mamnani L, Burrows N, Telfer BA, Carta F, Winum JY, Scozzafava A, Supuran CT, Williams KJ.. (2012) Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.. J Med Chem, 55 (11): (5591-5600). [PMID:22621623] [10.1021/jm300529u] |
| 27. Bozdag M, Dreker T, Henry C, Tosco P, Vallaro M, Fruttero R, Scozzafava A, Carta F, Supuran CT.. (2013) Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.. Bioorg Med Chem Lett, 23 (3): (715-719). [PMID:23265898] [10.1016/j.bmcl.2012.11.102] |
| 28. Gieling RG, Williams KJ.. (2013) Carbonic anhydrase IX as a target for metastatic disease.. Bioorg Med Chem, 21 (6): (1470-1476). [PMID:23098607] [10.1016/j.bmc.2012.09.062] |
| 29. Carta F, Akdemir A, Scozzafava A, Masini E, Supuran CT.. (2013) Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.. J Med Chem, 56 (11): (4691-4700). [PMID:23647428] [10.1021/jm400414j] |
| 30. Said HM, Hagemann C, Carta F, Katzer A, Polat B, Staab A, Scozzafava A, Anacker J, Vince GH, Flentje M, Supuran CT.. (2013) Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.. Bioorg Med Chem, 21 (13): (3949-3957). [PMID:23706268] [10.1016/j.bmc.2013.03.068] |
| 31. Leitans J, Sprudza A, Tanc M, Vozny I, Zalubovskis R, Tars K, Supuran CT.. (2013) 5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.. Bioorg Med Chem, 21 (17): (5130-5138). [PMID:23859774] [10.1016/j.bmc.2013.06.041] |
| 32. Biswas S, McKenna R, Supuran CT.. (2013) Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.. Bioorg Med Chem Lett, 23 (20): (5646-5649). [PMID:23993330] [10.1016/j.bmcl.2013.08.019] |
| 33. Pinard MA, Boone CD, Rife BD, Supuran CT, McKenna R.. (2013) Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.. Bioorg Med Chem, 21 (22): (7210-7215). [PMID:24090602] [10.1016/j.bmc.2013.08.033] |
| 34. De Luca L, Ferro S, Damiano FM, Supuran CT, Vullo D, Chimirri A, Gitto R.. (2014) Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors.. Eur J Med Chem, 71 (105-111). [PMID:24287559] [10.1016/j.ejmech.2013.10.071] |
| 35. Ghorab MM, Alsaid MS, Ceruso M, Nissan YM, Supuran CT.. (2014) Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties.. Bioorg Med Chem, 22 (14): (3684-3695). [PMID:24878360] [10.1016/j.bmc.2014.05.009] |
| 36. Moeker J, Mahon BP, Bornaghi LF, Vullo D, Supuran CT, McKenna R, Poulsen SA.. (2014) Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.. J Med Chem, 57 (20): (8635-8645). [PMID:25254302] [10.1021/jm5012935] |
| 37. Bozdag M, Ferraroni M, Carta F, Vullo D, Lucarini L, Orlandini E, Rossello A, Nuti E, Scozzafava A, Masini E, Supuran CT.. (2014) Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.. J Med Chem, 57 (21): (9152-9167). [PMID:25310626] [10.1021/jm501314c] |
| 38. Bozdag M, Pinard M, Carta F, Masini E, Scozzafava A, McKenna R, Supuran CT.. (2014) A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.. J Med Chem, 57 (22): (9673-9686). [PMID:25358036] [10.1021/jm501497m] |
| 39. Dudutienė V, Matulienė J, Smirnov A, Timm DD, Zubrienė A, Baranauskienė L, Morkūnaite V, Smirnovienė J, Michailovienė V, Juozapaitienė V, Mickevičiūtė A, Kazokaitė J, Bakšytė S, Kasiliauskaitė A, Jachno J, Revuckienė J, Kišonaitė M, Pilipuitytė V, Ivanauskaitė E, Milinavičiūtė G, Smirnovas V, Petrikaitė V, Kairys V, Petrauskas V, Norvaišas P, Lingė D, Gibieža P, Capkauskaitė E, Zakšauskas A, Kazlauskas E, Manakova E, Gražulis S, Ladbury JE, Matulis D.. (2014) Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.. J Med Chem, 57 (22): (9435-9446). [PMID:25358084] [10.1021/jm501003k] |
| 40. Chegaev K, Lazzarato L, Tamboli Y, Boschi D, Blangetti M, Scozzafava A, Carta F, Masini E, Fruttero R, Supuran CT, Gasco A.. (2014) Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents.. Bioorg Med Chem, 22 (15): (3913-3921). [PMID:25022971] [10.1016/j.bmc.2014.06.016] |
| 41. Bozdag M, Carta F, Vullo D, Akdemir A, Isik S, Lanzi C, Scozzafava A, Masini E, Supuran CT.. (2015) Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.. Bioorg Med Chem, 23 (10): (2368-2376). [PMID:25846066] [10.1016/j.bmc.2015.03.068] |
| 42. Mahon BP, Lomelino CL, Ladwig J, Rankin GM, Driscoll JM, Salguero AL, Pinard MA, Vullo D, Supuran CT, Poulsen SA, McKenna R.. (2015) Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.. J Med Chem, 58 (16): (6630-6638). [PMID:26203869] [10.1021/acs.jmedchem.5b00845] |
| 43. Ferraroni M, Carta F, Scozzafava A, Supuran CT.. (2016) Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.. J Med Chem, 59 (1): (462-473). [PMID:26688270] [10.1021/acs.jmedchem.5b01720] |
| 44. Alafeefy AM, Carta F, Ceruso M, Al-Tamimi AM, Al-Kahtani AA, Supuran CT.. (2016) Development of 3-(4-aminosulphonyl)-phenyl-2-mercapto-3H-quinazolin-4-ones as inhibitors of carbonic anhydrase isoforms involved in tumorigenesis and glaucoma.. Bioorg Med Chem, 24 (6): (1402-1407). [PMID:26875933] [10.1016/j.bmc.2016.02.011] |
| 45. Abdel Gawad NM, Amin NH, Elsaadi MT, Mohamed FM, Angeli A, De Luca V, Capasso C, Supuran CT.. (2016) Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines.. Bioorg Med Chem, 24 (13): (3043-3051). [PMID:27234893] [10.1016/j.bmc.2016.05.016] |
| 46. Akocak S, Alam MR, Shabana AM, Sanku RK, Vullo D, Thompson H, Swenson ER, Supuran CT, Ilies MA.. (2016) PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.. J Med Chem, 59 (10): (5077-5088). [PMID:27144971] [10.1021/acs.jmedchem.6b00492] |
| 47. Nocentini A, Ferraroni M, Carta F, Ceruso M, Gratteri P, Lanzi C, Masini E, Supuran CT.. (2016) Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations.. J Med Chem, 59 (23): (10692-10704). [PMID:27933963] [10.1021/acs.jmedchem.6b01389] |
| 48. Abdel-Aziz AA, Angeli A, El-Azab AS, Abu El-Enin MA, Supuran CT.. (2017) Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors.. Bioorg Med Chem, 25 (5): (1666-1671). [PMID:28161252] [10.1016/j.bmc.2017.01.032] |
| 49. Carta F, Birkmann A, Pfaff T, Buschmann H, Schwab W, Zimmermann H, Maresca A, Supuran CT.. (2017) Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.. J Med Chem, 60 (7): (3154-3164). [PMID:28272885] [10.1021/acs.jmedchem.7b00183] |
| 50. Fragai M, Comito G, Di Cesare Mannelli L, Gualdani R, Calderone V, Louka A, Richichi B, Francesconi O, Angeli A, Nocentini A, Gratteri P, Chiarugi P, Ghelardini C, Tadini-Buoninsegni F, Supuran CT, Nativi C.. (2017) Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).. J Med Chem, 60 (21): (9003-9011). [PMID:29048889] [10.1021/acs.jmedchem.7b01237] |
| 51. Angeli A, Tanini D, Viglianisi C, Panzella L, Capperucci A, Menichetti S, Supuran CT.. (2017) Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.. Bioorg Med Chem, 25 (8): (2518-2523). [PMID:28302505] [10.1016/j.bmc.2017.03.013] |
| 52. Angeli A, Carta F, Bartolucci G, Supuran CT.. (2017) Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.. Bioorg Med Chem, 25 (13): (3567-3573). [PMID:28522267] [10.1016/j.bmc.2017.05.014] |
| 53. Ferraroni M, Lucarini L, Masini E, Korsakov M, Scozzafava A, Supuran CT, Krasavin M.. (2017) 1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.. Bioorg Med Chem, 25 (17): (4560-4565). [PMID:28728897] [10.1016/j.bmc.2017.06.054] |
| 54. Angeli A, Abdel-Aziz AA, Nocentini A, El-Azab AS, Gratteri P, Supuran CT.. (2017) Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties.. Bioorg Med Chem, 25 (20): (5373-5379). [PMID:28789908] [10.1016/j.bmc.2017.07.056] |
| 55. Angapelly S, Ramya PVS, Angeli A, Del Prete S, Capasso C, Arifuddin M, Supuran CT.. (2017) Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors.. Bioorg Med Chem, 25 (20): (5726-5732). [PMID:28887000] [10.1016/j.bmc.2017.08.047] |
| 56. Angeli A, Tanini D, Capperucci A, Supuran CT.. (2017) Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors.. ACS Med Chem Lett, 8 (12): (1213-1217). [PMID:29259736] [10.1021/acsmedchemlett.7b00387] |
| 57. Nocentini A, Ceruso M, Bua S, Lomelino CL, Andring JT, McKenna R, Lanzi C, Sgambellone S, Pecori R, Matucci R, Filippi L, Gratteri P, Carta F, Masini E, Selleri S, Supuran CT.. (2018) Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.. J Med Chem, 61 (12): (5380-5394). [PMID:29851481] [10.1021/acs.jmedchem.8b00625] |
| 58. Bonardi A, Falsini M, Catarzi D, Varano F, Di Cesare Mannelli L, Tenci B, Ghelardini C, Angeli A, Supuran CT, Colotta V.. (2018) Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII.. Eur J Med Chem, 146 (47-59). [PMID:29407972] [10.1016/j.ejmech.2018.01.033] |
| 59. Angeli A, di Cesare Mannelli L, Trallori E, Peat TS, Ghelardini C, Carta F, Supuran CT.. (2018) Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.. ACS Med Chem Lett, 9 (5): (462-467). [PMID:29795760] [10.1021/acsmedchemlett.8b00076] |
| 60. Lomelino CL, Murray AB, Supuran CT, McKenna R.. (2018) Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.. ACS Med Chem Lett, 9 (7): (657-661). [PMID:30034596] [10.1021/acsmedchemlett.8b00100] |
| 61. Chiaramonte N, Bua S, Ferraroni M, Nocentini A, Bonardi A, Bartolucci G, Durante M, Lucarini L, Chiapponi D, Dei S, Manetti D, Teodori E, Gratteri P, Masini E, Supuran CT, Romanelli MN.. (2018) 2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.. Eur J Med Chem, 151 (363-375). [PMID:29635168] [10.1016/j.ejmech.2018.04.002] |
| 62. Kumar R, Vats L, Bua S, Supuran CT, Sharma PK.. (2018) Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors.. Eur J Med Chem, 155 (545-551). [PMID:29909339] [10.1016/j.ejmech.2018.06.021] |
| 63. Akgul O, Di Cesare Mannelli L, Vullo D, Angeli A, Ghelardini C, Bartolucci G, Alfawaz Altamimi AS, Scozzafava A, Supuran CT, Carta F.. (2018) Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.. J Med Chem, 61 (11): (4961-4977). [PMID:29746127] [10.1021/acs.jmedchem.8b00420] |
| 64. Eldehna WM, Abo-Ashour MF, Nocentini A, Gratteri P, Eissa IH, Fares M, Ismael OE, Ghabbour HA, Elaasser MM, Abdel-Aziz HA, Supuran CT.. (2017) Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.. Eur J Med Chem, 139 (250-262). [PMID:28802125] [10.1016/j.ejmech.2017.07.073] |
| 65. Vats L, Sharma V, Angeli A, Kumar R, Supuran CT, Sharma PK.. (2018) Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors.. Eur J Med Chem, 150 (678-686). [PMID:29571155] [10.1016/j.ejmech.2018.03.030] |
| 66. Bozdag M, Carta F, Ceruso M, Ferraroni M, McDonald PC, Dedhar S, Supuran CT.. (2018) Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.. J Med Chem, 61 (14): (6328-6338). [PMID:29962205] [10.1021/acs.jmedchem.8b00770] |
| 67. Mishra CB, Kumari S, Angeli A, Bua S, Buonanno M, Monti SM, Tiwari M, Supuran CT.. (2018) Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.. Eur J Med Chem, 156 (430-443). [PMID:30015076] [10.1016/j.ejmech.2018.07.019] |
| 68. Angeli A, Trallori E, Ferraroni M, Di Cesare Mannelli L, Ghelardini C, Supuran CT.. (2018) Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.. Eur J Med Chem, 157 (1214-1222). [PMID:30193219] [10.1016/j.ejmech.2018.08.096] |
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| 70. Zengin Kurt B, Sonmez F, Ozturk D, Akdemir A, Angeli A, Supuran CT.. (2019) Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies.. Eur J Med Chem, 183 (111702-111702). [PMID:31542715] [10.1016/j.ejmech.2019.111702] |
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| 73. Bozdag M, Ferraroni M, Ward C, Carta F, Bua S, Angeli A, Langdon SP, Kunkler IH, Al-Tamimi AS, Supuran CT.. (2019) Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.. Eur J Med Chem, 182 (111600-111600). [PMID:31419777] [10.1016/j.ejmech.2019.111600] |
| 74. Tanini D, Capperucci A, Ferraroni M, Carta F, Angeli A, Supuran CT.. (2020) Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors.. Eur J Med Chem, 185 (111811-111811). [PMID:31693947] [10.1016/j.ejmech.2019.111811] |
| 75. Eldehna WM, Abo-Ashour MF, Nocentini A, El-Haggar RS, Bua S, Bonardi A, Al-Rashood ST, Hassan GS, Gratteri P, Abdel-Aziz HA, Supuran CT.. (2019) Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.. Eur J Med Chem, 162 (147-160). [PMID:30445264] [10.1016/j.ejmech.2018.10.068] |
| 76. Zaraei SO, Abduelkarem AR, Anbar HS, Kobeissi S, Mohammad M, Ossama A, El-Gamal MI.. (2019) Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.. Eur J Med Chem, 179 (257-271). [PMID:31255926] [10.1016/j.ejmech.2019.06.052] |
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| 78. Krasavin M, Shetnev A, Sharonova T, Baykov S, Kalinin S, Nocentini A, Sharoyko V, Poli G, Tuccinardi T, Presnukhina S, Tennikova TB, Supuran CT.. (2019) Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment.. Eur J Med Chem, 164 (92-105). [PMID:30594030] [10.1016/j.ejmech.2018.12.049] |
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| 80. Vullo D, Durante M, Di Leva FS, Cosconati S, Masini E, Scozzafava A, Novellino E, Supuran CT, Carta F.. (2016) Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma.. J Med Chem, 59 (12): (5857-5867). [PMID:27253845] [10.1021/acs.jmedchem.6b00462] |
| 81. Bonardi A, Vermelho AB, da Silva Cardoso V, de Souza Pereira MC, da Silva Lara L, Selleri S, Gratteri P, Supuran CT, Nocentini A.. (2019) N-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis.. ACS Med Chem Lett, 10 (4): (413-418). [PMID:30996772] [10.1021/acsmedchemlett.8b00430] |
| 82. La Regina G, Puxeddu M, Nalli M, Vullo D, Gratteri P, Supuran CT, Nocentini A, Silvestri R.. (2020) Discovery of New 1,1'-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors.. ACS Med Chem Lett, 11 (5): (633-637). [PMID:32435363] [10.1021/acsmedchemlett.9b00437] |
| 83. Eldehna WM, Nocentini A, Elsayed ZM, Al-Warhi T, Aljaeed N, Alotaibi OJ, Al-Sanea MM, Abdel-Aziz HA, Supuran CT.. (2020) Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer.. ACS Med Chem Lett, 11 (5): (1022-1027). [PMID:32435420] [10.1021/acsmedchemlett.0c00094] |
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