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GKA 50 - ≥98%(HPLC), high purity , CAS No.851884-87-2

≥98%(HPLC)

CAS#: 851884-87-2
Formula: C₂₆H₂₈N₂O₆
Molecular Weight: 464.51
PubChem CID: 11340230

Item Number

G287266

Grouped product items
SKU	Size	Availability	Price
G287266-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
G287266-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$169.90
G287266-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$269.90
G287266-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$539.90

Glucokinase activator

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Glucokinase Activator

Basic Description

Synonyms	GKA 50;GKA50 \| 6-((3-((1S)-2-Methoxy-1-methylethoxy)-5-((1S)-1-methyl-2-phenylethoxy)benzoyl)amino)-3-pyridinecarboxylic acid \| GKA50 \| GKA-50 \| NCGC00387236-02 \| 6-(3-((S)-1-methoxypropan-2-yloxy)-5-((S)-1-phenylpropan-2-yloxy)benzamido)nicotinic acid \|
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent glucokinase activator (EC50= 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

RARA Tclin Retinoic acid receptor alpha (1324 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RARG Tclin Retinoic acid receptor gamma (1154 Activities)

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RARB Tclin Retinoic acid receptor beta (1232 Activities)

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Homo sapiens (32628 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gck Hexokinase type IV (278 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Canis familiaris (36305 Activities)

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Rattus norvegicus (775804 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Plasma (328 Activities)

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	6-[[3-[(2S)-1-methoxypropan-2-yl]oxy-5-[(2S)-1-phenylpropan-2-yl]oxybenzoyl]amino]pyridine-3-carboxylic acid
INCHI	InChI=1S/C26H28N2O6/c1-17(11-19-7-5-4-6-8-19)33-22-12-21(13-23(14-22)34-18(2)16-32-3)25(29)28-24-10-9-20(15-27-24)26(30)31/h4-10,12-15,17-18H,11,16H2,1-3H3,(H,30,31)(H,27,28,29)/t17-,18-/m0/s1
InChi Key	OCBMECSFDVUYQN-ROUUACIJSA-N
Canonical SMILES	CC(CC1=CC=CC=C1)OC2=CC(=CC(=C2)C(=O)NC3=NC=C(C=C3)C(=O)O)OC(C)COC
Isomeric SMILES	C[C@@H](CC1=CC=CC=C1)OC2=CC(=CC(=C2)C(=O)NC3=NC=C(C=C3)C(=O)O)O[C@@H](C)COC
PubChem CID	11340230
Molecular Weight	464.51

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

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GKA 50 - ≥98%(HPLC), high purity , CAS No.851884-87-2

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

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