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GLPG 0187 - ≥97%(HPLC), high purity , CAS No.1320346-97-1
Potent αv integrin inhibitor
Basic Description Synonyms GLPG0187 | 1320346-97-1 | GLPG-0187 | 43A5P87Z4T | L-Alanine, 3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl)-4-pyrimidinyl)amino)-N-((4-methoxyphenyl)sulfonyl) | (S)-3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pi Specifications & Purity ≥97%(HPLC) Biochemical and Physiological Mechanisms Potent αv integrin inhibitor (IC50values are 1.2-3.7 nM). Inhibits osteoclastic bone resorption and angiogenesisin vitroandin vivo. Suppresses epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells, without inhibiting cell growth. I Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description product description：
GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM.
Associated Targets(Human) Names and Identifiers IUPAC Name (2S)-3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl]pyrimidin-4-yl]amino]-2-[(4-methoxyphenyl)sulfonylamino]propanoic acid INCHI InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23)32-19(2)33-28(18)36-15-12-20(13-16-36)24-11-6-21-5-4-14-30-27(21)34-24/h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0/s1 InChi Key CXHCNOMGODVIKB-VWLOTQADSA-N Canonical SMILES CC1=C(N=C(N=C1N2CCC(CC2)C3=NC4=C(CCCN4)C=C3)C)NCC(C(=O)O)NS(=O)(=O)C5=CC=C(C=C5)OC Isomeric SMILES CC1=C(N=C(N=C1N2CCC(CC2)C3=NC4=C(CCCN4)C=C3)C)NC[C@@H](C(=O)O)NS(=O)(=O)C5=CC=C(C=C5)OC PubChem CID 53340771 Molecular Weight 595.71
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 5.96, Max Conc. mM: 10
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K2101078