GLPG 0974 - ≥98%(HPLC), high purity , CAS No.1391076-61-1, Antagonist of FFA2 receptor

Item Number

G287679

Grouped product items
SKU	Size	Availability	Price
G287679-1mg	1mg	In stock	$33.90
G287679-5mg	5mg	In stock	$139.90
G287679-10mg	10mg	In stock	$232.90
G287679-25mg	25mg	In stock	$484.90

Potent FFA2 (GPR43) antagonist

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Basic Description

Synonyms	GLPG0974\|1391076-61-1\|GLPG-0974\|GLPG 0974\|X7REK61AIS\|4-[[(2R)-1-(1-benzothiophene-3-carbonyl)-2-methylazetidine-2-carbonyl]-[(3-chlorophenyl)methyl]amino]butanoic acid\|CHEMBL3353541\|4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][
Specifications & Purity	≥98%(HPLC)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of FFA2 receptor
Product Description	Product description GLPG0974 is a free fatty acid receptor-2 (FFA2/GPR43) antagonist with an IC50 of 9 nM.

Names and Identifiers

IUPAC Name	4-[[(2R)-1-(1-benzothiophene-3-carbonyl)-2-methylazetidine-2-carbonyl]-[(3-chlorophenyl)methyl]amino]butanoic acid
INCHI	InChI=1S/C25H25ClN2O4S/c1-25(11-13-28(25)23(31)20-16-33-21-9-3-2-8-19(20)21)24(32)27(12-5-10-22(29)30)15-17-6-4-7-18(26)14-17/h2-4,6-9,14,16H,5,10-13,15H2,1H3,(H,29,30)/t25-/m1/s1
InChi Key	MPMKMQHJHDHPBE-RUZDIDTESA-N
Canonical SMILES	CC1(CCN1C(=O)C2=CSC3=CC=CC=C32)C(=O)N(CCCC(=O)O)CC4=CC(=CC=C4)Cl
Isomeric SMILES	C[C@@]1(CCN1C(=O)C2=CSC3=CC=CC=C32)C(=O)N(CCCC(=O)O)CC4=CC(=CC=C4)Cl
Alternate CAS	1391076-61-1
PubChem CID	57520598
MeSH Entry Terms	4-(((R)-1-(benzo(b)thiophene-3-carbonyl)-2-methyl-azetidine-2-carbonyl)-(3-chloro-benzyl)-amino)-butyric acid;GLPG0974
Molecular Weight	485

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
F2302432	Certificate of Analysis	Apr 10, 2023	G287679
F2302433	Certificate of Analysis	Apr 10, 2023	G287679
F2302434	Certificate of Analysis	Apr 10, 2023	G287679
F2302436	Certificate of Analysis	Apr 10, 2023	G287679
F2302437	Certificate of Analysis	Apr 10, 2023	G287679
F2302438	Certificate of Analysis	Apr 10, 2023	G287679
F2302439	Certificate of Analysis	Apr 10, 2023	G287679
F2302442	Certificate of Analysis	Apr 10, 2023	G287679

References

1. Pizzonero M, Dupont S, Babel M, Beaumont S, Bienvenu N, Blanqué R, Cherel L, Christophe T, Crescenzi B, De Lemos E et al.. (2014) Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.. J Med Chem, 57 (23): (10044-57). [PMID:25380412]
2. Namour F, Galien R, Van Kaem T, Van der Aa A, Vanhoutte F, Beetens J, Van't Klooster G. (2016) Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects.. Br J Clin Pharmacol, 82 (1): (139-48). [PMID:26852904]

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Basic Description