Glucosamine - 10mM in DMSO, high purity , CAS No.3416-24-8

  • 10mM in DMSO
Item Number
G423487
Grouped product items
SKUSizeAvailabilityPrice Qty
G423487-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90

HIF Inhibitors

Basic Description

Synonyms2-Amino-2-Deoxy-D-Glucopyranose | 2-Amino-2-Deoxy-D-Glucopyranoside | 2-Amino-2-Deoxy-D-Glucose | 2-Amino-2-Deoxy-Glucopyranose | 2-Amino-2-Deoxy-Glucopyranoside | 2-Amino-2-Deoxy-Glucose | 2-Deoxy-2-Amino-D-Glucopyranose | 2-Deoxy-2-Amino-D-Glucopyranoside | 2-Deoxy-2-A
Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsGlucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine(GS) treatment selectively downregulate
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Information

Glucosamine Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine(GS) treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.

Product Properties

pKapKₐ: 12.27 (Predicted), pKₐ: 8.44 (Predicted)

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-1080 (3966 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MG-63 (795 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC22A1 Tchem Solute carrier family 22 member 1 (646 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FIBCD1 Tbio Fibrinogen C domain-containing protein 1 (33 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mmp2 Matrix metalloproteinase-2 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW (181 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cartilage (29 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trametes versicolor (86 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Poria (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Canonical SMILES C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)N)O)O)O
Isomeric SMILES C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)N)O)O)O
RTECS LZ6665000
PubChem CID 439213
Molecular Weight 179.17
Beilstein 1423209

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Refractive Indexn20D1.6 (Predicted)
Boil Point(°C)~449.9° C at 760 mmHg (Predicted)
Melt Point(°C)109-111° C

Safety and Hazards(GHS)

RTECS LZ6665000

Related Documents

Citations of This Product

1. Shuwei Yuan, Miaomiao Zhang, Zhen Yao, Jiangyun Liu, Xiang Li, Zhenqing Zhang, Duxin Li.  (2024)  Isolation, structural characterization, and bioactivities of neutral polysaccharides from Zizania latifolia.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  254  (127679).  [PMID:37890741] [10.1016/j.ijbiomac.2023.127679]
2. Qihong Jiang, Lin Chen, Rui Wang, Yin Chen, Shanggui Deng, Guoxin Shen, Shulai Liu, Xingwei Xiang.  (2024)  Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathway.  Food Science and Human Wellness,  13  (5): (842).  [PMID:10025403] [10.26599/FSHW.2022.9250072]
3. Yang Liu, Limei Ran, Yahong Wang, Peng Wan, Hongli Zhou.  (2023)  Basic characterization, antioxidant and immunomodulatory activities of polysaccharides from sea buckthorn leaves.  FITOTERAPIA,  169  (105592).  [PMID:37343686] [10.1016/j.fitote.2023.105592]
4. Shuwei Yuan, Jiahui Wang, Xiang Li, Xun Zhu, Zhenqing Zhang, Duxin Li.  (2023)  Study on the structure, antioxidant activity and degradation pattern of polysaccharides isolated from lotus seedpod.  CARBOHYDRATE POLYMERS,  316  (121065).  [PMID:37321745] [10.1016/j.carbpol.2023.121065]
5. Cui Cao, Lilong Wang, Xueqian Zhang, Chunqing Ai, Zhongfu Wang, Linjuan Huang, Shuang Song, Beiwei Zhu.  (2023)  Interaction between Bacteroidetes species in the fermentation of Lycium barbarum arabinogalactan.  FOOD CHEMISTRY,  409  (135288).  [PMID:36584527] [10.1016/j.foodchem.2022.135288]
6. Zhengyu Hu, Jiaming Wang, Long Jin, Tieqiang Zong, Yuanqi Duan, Jinfeng Sun, Wei Zhou, Gao Li.  (2022)  Preparation, Characterization and Anti-Complementary Activity of Three Novel Polysaccharides from Cordyceps militaris.  Polymers,  14  (21): (4636).  [PMID:36365633] [10.3390/polym14214636]
7. Dongxue Cao, Enwei Wei, Zeyu Wang, Zhengyu Hu, Ling Qi, Hongli Zhou, Jingli Zhao.  (2022)  Microwave-assisted extraction, structural elucidation, and in vitro anti-glioma and immunostimulatory activity of polysaccharide from Panax ginseng C. A. Meyer.  INDUSTRIAL CROPS AND PRODUCTS,  189  (115729).  [PMID:] [10.1016/j.indcrop.2022.115729]
8. Jinfang Zhang, Baoyue Zhu, Xiaojian Xu, Yihan Liu, Qinggang Li, Yu Li, Fuping Lu.  (2022)  Remodeling Bacillus amyloliquefaciens Cell Wall Rigidity to Reduce Cell Lysis and Increase the Yield of Heterologous Proteins.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (34): (10552–10562).  [PMID:35984403] [10.1021/acs.jafc.2c04454]
9. Zhengyu Hu, Ruiying Yu, Jinfeng Sun, Yuanqi Duan, Hongli Zhou, Wei Zhou, Gao Li.  (2022)  Static decolorization of polysaccharides from the leaves of Rhododendron dauricum: Process optimization, characterization and antioxidant activities.  PROCESS BIOCHEMISTRY,  121  (113).  [PMID:] [10.1016/j.procbio.2022.06.025]
10. Lei Li, Yun Fang, Yongmei Xia, Chunling Bo, Ye Fan.  (2022)  Monosaccharides driving the formation of conjugated linoleic acid vesicles in near-neutral solutions via weak noncovalent bonding interactions.  JOURNAL OF MOLECULAR LIQUIDS,  351  (118656).  [PMID:] [10.1016/j.molliq.2022.118656]
11. Hualing Xie, Jingyu Fang, Mohamed A. Farag, Zhenhao Li, Peilong Sun, Ping Shao.  (2022)  Dendrobium officinale leaf polysaccharides regulation of immune response and gut microbiota composition in cyclophosphamide-treated mice.  Food Chemistry-X,  13  (100235).  [PMID:35499019] [10.1016/j.fochx.2022.100235]
12. Yilin Zhang, Mengqi Wu, Jingrui Xi, Chen Pan, Zhizhen Xu, Wei Xia, Wenqing Zhang.  (2021)  Multiple-fingerprint analysis of Poria cocos polysaccharide by HPLC combined with chemometrics methods.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  198  (114012).  [PMID:33713882] [10.1016/j.jpba.2021.114012]
13. Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin, Liming Zhao.  (2021)  Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease.  Journal of Functional Foods,  77  (104333).  [PMID:] [10.1016/j.jff.2020.104333]
14. Yuhuan Ma, Wenwei Zheng, Houhuang Chen, Xiang Shao, Pingdong Lin, Xianxiang Liu, Xihai Li, Hongzhi Ye.  (2018)  Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,  42  (1): (61-70).  [PMID:29568900] [10.3892/ijmm.2018.3587]
15. Li Guo, Shan Huang, Jinqing Qu.  (2018)  Synthesis and properties of high-functionality hydroxyl-terminated polyurethane dispersions.  PROGRESS IN ORGANIC COATINGS,  119  (214).  [PMID:] [10.1016/j.porgcoat.2018.02.033]
16. Hongyan Zhu, Wanwan Liu, Ziting Cheng, Ke Yao, Yu Yang, Bohui Xu, Gaoxing Su.  (2017)  Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  18  (10): (2029).  [PMID:28937584] [10.3390/ijms18102029]
17. Jianbing Zhu, Meiling Xiao, Kui Li, Changpeng Liu, Xiao Zhao, Wei Xing.  (2016)  Active Pt3Ni (111) Surface of Pt3Ni Icosahedron for Oxygen Reduction.  ACS Applied Materials & Interfaces,  (44): (30066–30071).  [PMID:27735187] [10.1021/acsami.6b04237]
18. Ying-Hua Zhang, Jia-Qi Liu, Di Xu, Xin-Huai Zhao.  (2015)  Impacts of glucosamine/oligochitosan glycation and cross-linking by transglutaminase on the structure and in vitro antigenicity of whey proteins.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,  69  (2): (169-176).  [PMID:] [10.1111/1471-0307.12246]

References

1. Shuwei Yuan, Miaomiao Zhang, Zhen Yao, Jiangyun Liu, Xiang Li, Zhenqing Zhang, Duxin Li.  (2024)  Isolation, structural characterization, and bioactivities of neutral polysaccharides from Zizania latifolia.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  254  (127679).  [PMID:37890741] [10.1016/j.ijbiomac.2023.127679]
2. Qihong Jiang, Lin Chen, Rui Wang, Yin Chen, Shanggui Deng, Guoxin Shen, Shulai Liu, Xingwei Xiang.  (2024)  Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathway.  Food Science and Human Wellness,  13  (5): (842).  [PMID:10025403] [10.26599/FSHW.2022.9250072]
3. Yang Liu, Limei Ran, Yahong Wang, Peng Wan, Hongli Zhou.  (2023)  Basic characterization, antioxidant and immunomodulatory activities of polysaccharides from sea buckthorn leaves.  FITOTERAPIA,  169  (105592).  [PMID:37343686] [10.1016/j.fitote.2023.105592]
4. Shuwei Yuan, Jiahui Wang, Xiang Li, Xun Zhu, Zhenqing Zhang, Duxin Li.  (2023)  Study on the structure, antioxidant activity and degradation pattern of polysaccharides isolated from lotus seedpod.  CARBOHYDRATE POLYMERS,  316  (121065).  [PMID:37321745] [10.1016/j.carbpol.2023.121065]
5. Cui Cao, Lilong Wang, Xueqian Zhang, Chunqing Ai, Zhongfu Wang, Linjuan Huang, Shuang Song, Beiwei Zhu.  (2023)  Interaction between Bacteroidetes species in the fermentation of Lycium barbarum arabinogalactan.  FOOD CHEMISTRY,  409  (135288).  [PMID:36584527] [10.1016/j.foodchem.2022.135288]
6. Zhengyu Hu, Jiaming Wang, Long Jin, Tieqiang Zong, Yuanqi Duan, Jinfeng Sun, Wei Zhou, Gao Li.  (2022)  Preparation, Characterization and Anti-Complementary Activity of Three Novel Polysaccharides from Cordyceps militaris.  Polymers,  14  (21): (4636).  [PMID:36365633] [10.3390/polym14214636]
7. Dongxue Cao, Enwei Wei, Zeyu Wang, Zhengyu Hu, Ling Qi, Hongli Zhou, Jingli Zhao.  (2022)  Microwave-assisted extraction, structural elucidation, and in vitro anti-glioma and immunostimulatory activity of polysaccharide from Panax ginseng C. A. Meyer.  INDUSTRIAL CROPS AND PRODUCTS,  189  (115729).  [PMID:] [10.1016/j.indcrop.2022.115729]
8. Jinfang Zhang, Baoyue Zhu, Xiaojian Xu, Yihan Liu, Qinggang Li, Yu Li, Fuping Lu.  (2022)  Remodeling Bacillus amyloliquefaciens Cell Wall Rigidity to Reduce Cell Lysis and Increase the Yield of Heterologous Proteins.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (34): (10552–10562).  [PMID:35984403] [10.1021/acs.jafc.2c04454]
9. Zhengyu Hu, Ruiying Yu, Jinfeng Sun, Yuanqi Duan, Hongli Zhou, Wei Zhou, Gao Li.  (2022)  Static decolorization of polysaccharides from the leaves of Rhododendron dauricum: Process optimization, characterization and antioxidant activities.  PROCESS BIOCHEMISTRY,  121  (113).  [PMID:] [10.1016/j.procbio.2022.06.025]
10. Lei Li, Yun Fang, Yongmei Xia, Chunling Bo, Ye Fan.  (2022)  Monosaccharides driving the formation of conjugated linoleic acid vesicles in near-neutral solutions via weak noncovalent bonding interactions.  JOURNAL OF MOLECULAR LIQUIDS,  351  (118656).  [PMID:] [10.1016/j.molliq.2022.118656]
11. Hualing Xie, Jingyu Fang, Mohamed A. Farag, Zhenhao Li, Peilong Sun, Ping Shao.  (2022)  Dendrobium officinale leaf polysaccharides regulation of immune response and gut microbiota composition in cyclophosphamide-treated mice.  Food Chemistry-X,  13  (100235).  [PMID:35499019] [10.1016/j.fochx.2022.100235]
12. Yilin Zhang, Mengqi Wu, Jingrui Xi, Chen Pan, Zhizhen Xu, Wei Xia, Wenqing Zhang.  (2021)  Multiple-fingerprint analysis of Poria cocos polysaccharide by HPLC combined with chemometrics methods.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  198  (114012).  [PMID:33713882] [10.1016/j.jpba.2021.114012]
13. Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin, Liming Zhao.  (2021)  Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease.  Journal of Functional Foods,  77  (104333).  [PMID:] [10.1016/j.jff.2020.104333]
14. Yuhuan Ma, Wenwei Zheng, Houhuang Chen, Xiang Shao, Pingdong Lin, Xianxiang Liu, Xihai Li, Hongzhi Ye.  (2018)  Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,  42  (1): (61-70).  [PMID:29568900] [10.3892/ijmm.2018.3587]
15. Li Guo, Shan Huang, Jinqing Qu.  (2018)  Synthesis and properties of high-functionality hydroxyl-terminated polyurethane dispersions.  PROGRESS IN ORGANIC COATINGS,  119  (214).  [PMID:] [10.1016/j.porgcoat.2018.02.033]
16. Hongyan Zhu, Wanwan Liu, Ziting Cheng, Ke Yao, Yu Yang, Bohui Xu, Gaoxing Su.  (2017)  Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  18  (10): (2029).  [PMID:28937584] [10.3390/ijms18102029]
17. Jianbing Zhu, Meiling Xiao, Kui Li, Changpeng Liu, Xiao Zhao, Wei Xing.  (2016)  Active Pt3Ni (111) Surface of Pt3Ni Icosahedron for Oxygen Reduction.  ACS Applied Materials & Interfaces,  (44): (30066–30071).  [PMID:27735187] [10.1021/acsami.6b04237]
18. Ying-Hua Zhang, Jia-Qi Liu, Di Xu, Xin-Huai Zhao.  (2015)  Impacts of glucosamine/oligochitosan glycation and cross-linking by transglutaminase on the structure and in vitro antigenicity of whey proteins.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,  69  (2): (169-176).  [PMID:] [10.1111/1471-0307.12246]

Solution Calculators