Basic Description

Product Name	Glucose Transporter GLUT1 Antibody - Primary antibody, specific to Glucose Transporter GLUT1, Rabbit IgG
Synonyms	Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity) antibody \| CSE antibody \| DYT17 antibody \| DYT18 antibody \| DYT9 antibody \| EIG12 antibody \| erythrocyte/brain antibody \| Erythrocyte/hepatoma glucose transporter antibody \| facil
Specifications & Purity	ExactAb™, Validated, Carrier Free, High performance, Lot by Lot
Host species	Rabbit
Specificity	Glucose Transporter GLUT1
Immunogen	Recombinant GLUT1 expressed in E.coli (AA 251-329)
Positive Control	WB: A549, HeLa, Jurkat, HT-29 and NIH/3T3 cell lysates.
Conjugation	Unconjugated
Grade	Carrier Free, ExactAb™, High Performance, Validated
Note	20μl卖完停产，不再备货
Product Description	Rabbit anti Human Glucose Transporter GLUT1 Antibody, Polyclonal, could be used for WB and so on. Application WB: 0.01-2 µg/mL Protein Function Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.

Product Properties

Isotype	Rabbit IgG
SDS-PAGE	150 kDa
Purification Method	Antigen affinity purified + Protein A purified
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

SLC2A1 Tchem Solute carrier family 2, facilitated glucose transporter member 1 (0 Activities)

Discover Target: SLC2A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Application

Application	Dilution info
WB	0.01-2 µg/mL

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0404295	Certificate of Analysis	Apr 09, 2024	Ab105588
ZJ23F1101790	Certificate of Analysis	Nov 24, 2023	Ab105588
ZJ23F1101788	Certificate of Analysis	Nov 24, 2023	Ab105588

FAQs and Articles

References

1. Wang D, Chu PC, Yang CN, Yan R, Chuang YC, Kulp SK, Chen CS. (2012) Development of a novel class of glucose transporter inhibitors.. J Med Chem, 55 (8): (3827-36). [PMID:22468970] [10.1021/op500134e]
2. Meng W, Ellsworth BA, Nirschl AA, McCann PJ, Patel M, Girotra RN, Wu G, Sher PM, Morrison EP, Biller SA, Zahler R, Deshpande PP, Pullockaran A, Hagan DL, Morgan N, Taylor JR, Obermeier MT, Humphreys WG, Khanna A, Discenza L, Robertson JG, Wang A, Han S, Wetterau JR, Janovitz EB, Flint OP, Whaley JM, Washburn WN.. (2008) Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.. J Med Chem, 51 (5): (1145-1149). [PMID:18260618] [10.1021/jm701272q]
3. Shapira R, Rudnick S, Daniel B, Viskind O, Aisha V, Richman M, Ayasolla KR, Perelman A, Chill JH, Gruzman A, Rahimipour S.. (2013) Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress.. J Med Chem, 56 (17): (6709-6718). [PMID:23984871] [10.1021/jm4005225]
4. Ren Y, Yuan C, Qian Y, Chai HB, Chen X, Goetz M, Kinghorn AD.. (2014) Constituents of an extract of Cryptocarya rubra housed in a repository with cytotoxic and glucose transport inhibitory effects.. J Nat Prod, 77 (3): (550-556). [PMID:24344605] [10.1021/np400809w]
5. Siebeneicher H, Bauser M, Buchmann B, Heisler I, Müller T, Neuhaus R, Rehwinkel H, Telser J, Zorn L.. (2016) Identification of novel GLUT inhibitors.. Bioorg Med Chem Lett, 26 (7): (1732-1737). [PMID:26949183] [10.1016/j.bmcl.2016.02.050]
6. Granchi C, Fortunato S, Minutolo F.. (2016) Anticancer agents interacting with membrane glucose transporters.. Medchemcomm, 7 (9): (1716-1729). [PMID:28042452] [10.1039/C6MD00287K]
7. Wei C, Bajpai R, Sharma H, Heitmeier M, Jain AD, Matulis SM, Nooka AK, Mishra RK, Hruz PW, Schiltz GE, Shanmugam M.. (2017) Development of GLUT4-selective antagonists for multiple myeloma therapy.. Eur J Med Chem, 139 (573-586). [PMID:28837922] [10.1016/j.ejmech.2017.08.029]
8. Perrone MG, Vitale P, Ferorelli S, Boccarelli A, Coluccia M, Pannunzio A, Campanella F, Di Mauro G, Bonaccorso C, Fortuna CG, Scilimati A.. (2017) Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier.. Eur J Med Chem, 141 (404-416). [PMID:29032033] [10.1016/j.ejmech.2017.09.066]
9. Liu KG, Kim JI, Olszewski K, Barsotti AM, Morris K, Lamarque C, Yu X, Gaffney J, Feng XJ, Patel JP, Poyurovsky MV.. (2020) Discovery and Optimization of Glucose Uptake Inhibitors.. J Med Chem, 63 (10): (5201-5211). [PMID:32282207] [10.1021/acs.jmedchem.9b02153]
10. Tilekar K,Upadhyay N,Hess JD,Macias LH,Mrowka P,Aguilera RJ,Meyer-Almes FJ,Iancu CV,Choe JY,Ramaa CS. (2020) Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential.. Eur J Med Chem, 202 (112603-112603). [PMID:32634629] [10.1016/j.ejmech.2020.112603]
11. Fukumoto, H H, Seino, S S, Imura, H H, Seino, Y Y and Bell, G I GI.. (1988) Characterization and expression of human HepG2/erythrocyte glucose-transporter gene.. Diabetes, [PMID:2834252]
12. Mueckler, M M and 8 more authors.. (1985) Sequence and structure of a human glucose transporter.. Science (New York, N.Y.), (6): [PMID:3839598]
13. Klepper, J J and 6 more authors.. (1999) Defective glucose transport across brain tissue barriers: a newly recognized neurological syndrome.. Neurochemical research, [PMID:10227690]
14. Wang, D D, Kranz-Eble, P P and De Vivo, D C DC.. (2000) Mutational analysis of GLUT1 (SLC2A1) in Glut-1 deficiency syndrome.. Human mutation, [PMID:10980529]
15. Klepper, J J and 7 more authors.. (2001) Autosomal dominant transmission of GLUT1 deficiency.. Human molecular genetics, (1): [PMID:11136715]
16. Brockmann, K K and 12 more authors.. (2001) Autosomal dominant glut-1 deficiency syndrome and familial epilepsy.. Annals of neurology, [PMID:11603379]
17. Pascual, Juan M JM, Van Heertum, Ronald L RL, Wang, Dong D, Engelstad, Kristin K and De Vivo, Darryl C DC.. (2002) Imaging the metabolic footprint of Glut1 deficiency on the brain.. Annals of neurology, [PMID:12325075]
18. Overweg-Plandsoen, W C G WC and 6 more authors.. (2003) GLUT-1 deficiency without epilepsy--an exceptional case.. Journal of inherited metabolic disease, [PMID:14605501]
19. Wang, Dong D and 6 more authors.. (2005) Glut-1 deficiency syndrome: clinical, genetic, and therapeutic aspects.. Annals of neurology, [PMID:15622525]
20. Chi, An A and 16 more authors.. (2006) Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.. Journal of proteome research, [PMID:17081065]
21. Mueckler, Mike M and Makepeace, Carol C.. (2008) Transmembrane segment 6 of the Glut1 glucose transporter is an outer helix and contains amino acid side chains essential for transport activity.. The Journal of biological chemistry, (25): [PMID:18245775]
22. Khan, Anwar A AA and 9 more authors.. (2008) Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1.. The Journal of biological chemistry, (23): [PMID:18347014]
23. Weber, Yvonne G YG and 28 more authors.. (2008) GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak.. The Journal of clinical investigation, [PMID:18451999]
24. Daub, Henrik H and 9 more authors.. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.. Molecular cell, (8): [PMID:18691976]
25. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973]
26. Mueckler, Mike M and Makepeace, Carol C.. (2009) Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesis.. Biochemistry, (30): [PMID:19449892]
27. Schneider, Susanne A SA and 7 more authors.. (2009) GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias.. Movement disorders : official journal of the Movement Disorder Society, (15): [PMID:19630075]
28. Suls, Arvid A and 14 more authors.. (2009) Early-onset absence epilepsy caused by mutations in the glucose transporter GLUT1.. Annals of neurology, [PMID:19798636]
29. Pérez-Dueñas, Belén B and 6 more authors.. (2009) Childhood chorea with cerebral hypotrophy: a treatable GLUT1 energy failure syndrome.. Archives of neurology, [PMID:19901175]
30. Leen, Wilhelmina G WG and 52 more authors.. (2010) Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder.. Brain : a journal of neurology, [PMID:20129935]
31. Klepper, J J and 5 more authors.. (2009) Autosomal recessive inheritance of GLUT1 deficiency syndrome.. Neuropediatrics, [PMID:20221955]
32. Mullen, S A SA, Suls, A A, De Jonghe, P P, Berkovic, S F SF and Scheffer, I E IE.. (2010) Absence epilepsies with widely variable onset are a key feature of familial GLUT1 deficiency.. Neurology, (3): [PMID:20574033]
33. Urbizu, Aintzane A and 7 more authors.. (2010) Paroxysmal exercise-induced dyskinesia, writer's cramp, migraine with aura and absence epilepsy in twin brothers with a novel SLC2A1 missense mutation.. Journal of the neurological sciences, (15): [PMID:20621801]
34. Afawi, Zaid Z and 8 more authors.. (2010) Mild adolescent/adult onset epilepsy and paroxysmal exercise-induced dyskinesia due to GLUT1 deficiency.. Epilepsia, [PMID:21204808]
35. Rigbolt, Kristoffer T G KT and 9 more authors.. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.. Science signaling, (15): [PMID:21406692]
36. Flatt, Joanna F JF and 12 more authors.. (2011) Stomatin-deficient cryohydrocytosis results from mutations in SLC2A1: a novel form of GLUT1 deficiency syndrome.. Blood, (10): [PMID:21791420]
37. Weber, Y G YG and 15 more authors.. (2011) Paroxysmal choreoathetosis/spasticity (DYT9) is caused by a GLUT1 defect.. Neurology, (6): [PMID:21832227]
38. Striano, P P and 19 more authors.. (2012) GLUT1 mutations are a rare cause of familial idiopathic generalized epilepsy.. Neurology, (21): [PMID:22282645]
39. Bawazir, Waleed M WM and 9 more authors.. (2012) An infant with pseudohyperkalemia, hemolysis, and seizures: cation-leaky GLUT1-deficiency syndrome due to a SLC2A1 mutation.. The Journal of clinical endocrinology and metabolism, [PMID:22492876]
40. Van Damme, Petra P and 15 more authors.. (2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:22814378]
41. Zhou, Houjiang H and 6 more authors.. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome.. Journal of proteome research, (4): [PMID:23186163]
42. Rungaldier, Stefanie S, Oberwagner, Walter W, Salzer, Ulrich U, Csaszar, Edina E and Prohaska, Rainer R.. (2013) Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.. Biochimica et biophysica acta, [PMID:23219802]
43. Arsov, Todor T and 12 more authors.. (2012) Glucose transporter 1 deficiency in the idiopathic generalized epilepsies.. Annals of neurology, [PMID:23280796]
44. Steinberg, Florian F and 7 more authors.. (2013) A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport.. Nature cell biology, [PMID:23563491]
45. Salas, Mónica M and 8 more authors.. (2013) Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation.. American journal of physiology. Cell physiology, (1): [PMID:23615963]
46. Deng, Dong D and 6 more authors.. (2014) Crystal structure of the human glucose transporter GLUT1.. Nature, (5): [PMID:24847886]
47. Aït-Ali, Najate N and 18 more authors.. (2015) Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.. Cell, (7): [PMID:25957687]
48. Lee, Eunice E EE and 11 more authors.. (2015) A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.. Molecular cell, (4): [PMID:25982116]
49. Kapoor, Khyati K and 10 more authors.. (2016) Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.. Proceedings of the National Academy of Sciences of the United States of America, (26): [PMID:27078104]
50. Ung, Peter Man-Un PM and 6 more authors.. (2016) Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening.. ACS chemical biology, (15): [PMID:27128978]
51. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460]
52. Katrina Meyer,Marieluise Kirchner,Bora Uyar,Jing-Yuan Cheng,Giulia Russo,Luis R Hernandez-Miranda,Anna Szymborska,Henrik Zauber,Ina-Maria Rudolph,Thomas E Willnow,Altuna Akalin,Volker Haucke,Holger Gerhardt,Carmen Birchmeier,Ralf Kühn,Michael Krauss,Sebastian Diecke,Juan M Pascual,Matthias Selbach. (2018-09-11) Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs.. Cell, 175 ((1)): (239-253). [PMID:30197081]

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SKU	Size	Availability	Price
Ab105588-10μl	10μl	In stock	$66.90
Ab105588-50μl	50μl	In stock	$189.90
Ab105588-100μl	100μl	In stock	$299.90
Ab105588-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,299.90

Glucose Transporter GLUT1 Antibody - Primary antibody, specific to Glucose Transporter GLUT1, Rabbit IgG