Click Here for 5% Off Your First Aladdin Purchase!

Gly-Gly - BioUltra,≥99.5%(NT), high purity , CAS No.556-50-3

  • Ultra pure
  • ≥99.5%(NT)
Item Number
G119491
Grouped product items
SKUSizeAvailabilityPrice Qty
G119491-10g
10g
In stock
$61.90
G119491-50g
50g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$230.90
View related series
Biological Buffers

Basic Description

SynonymsGlycylglycine|556-50-3|Diglycine|N-GLYCYLGLYCINE|Gly-Gly|Glycyl-glycine|Glycine dipeptide|2-(2-Aminoacetamido)Acetic Acid|Glycine, glycyl-|Glycyl Glycine|Glycine, N-glycyl-|2-[(2-aminoacetyl)amino]acetic acid|Gly2|Gly-Gly-OH|H-Gly-Gly-OH|2-(Aminoacetamido
Specifications & PurityUltra pure, ≥99.5%(NT)
Biochemical and Physiological MechanismsGly-Gly or diglycine is the simplest dipeptide. It may possess proteolytic properties. Gly-gly is hydrolyzed by glycylglycine dipeptidase.
Shipped InNormal
GradeUltra pure
Product Description

Gly-Gly has been used as a buffer for the measurement of glucose-6-phosphate dehydrogenase (G6PDH) activity and as a component of luciferase assay buffer.
Gly-Gly has been used as a buffer for the measurement of glucose-6-phosphate dehydrogenase (G6PDH) activity and as a component of luciferase assay buffer.

Associated Targets

SLC15A2 Tchem Solute carrier family 15 member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC15A1 Tchem Solute carrier family 15 member 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACE Tclin Angiotensin-converting enzyme 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OR51E2 Tchem Olfactory receptor 51E2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[(2-aminoacetyl)amino]acetic acid
INCHI InChI=1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)
InChi Key YMAWOPBAYDPSLA-UHFFFAOYSA-N
Canonical SMILES C(C(=O)NCC(=O)O)N
Isomeric SMILES C(C(=O)NCC(=O)O)N
WGK Germany 3
PubChem CID 11163
Molecular Weight 132.12
Beilstein 1765223

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
B2307098Certificate of AnalysisJul 14, 2022 G119491
H2203376Certificate of AnalysisJul 14, 2022 G119491
H2203377Certificate of AnalysisJul 14, 2022 G119491

Chemical and Physical Properties

SolubilitySoluble in water (132 g/L) at 20°C, and ethanol (slightly solube).
Melt Point(°C)260-262°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Hazard Statements

H319:Causes serious eye irritation

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

WGK Germany 3
Merck Index 4503

Related Documents

Alternative Products

FAQs and Articles

References

1. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ et al..  (2011)  Systematic and quantitative assessment of the ubiquitin-modified proteome..  Mol Cell,  44  (2): (325-40).  [PMID:21906983]
2. Biegel A, Gebauer S, Hartrodt B, Brandsch M, Neubert K, Thondorf I.  (2005)  Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1..  J Med Chem,  48  (13): (4410-9).  [PMID:15974593]
3. Vig BS, Stouch TR, Timoszyk JK, Quan Y, Wall DA, Smith RL, Faria TN.  (2006)  Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding..  J Med Chem,  49  (12): (3636-44).  [PMID:16759105]
4. G C Cook.  (1976-04-01)  Impairment of jejunal absorption rate of carnosine by glycylglycine in man in vivo..  Gut,  17  ((4)): (252-257).  [PMID:773786]
5. Griet Van Zeebroeck,Beatriz Monge Bonini,Matthias Versele,Johan M Thevelein.  (2008-12-09)  Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor..  Nature chemical biology,  ((1)): (45-52).  [PMID:19060912]
6. Eduard Schreiner,Nisanth N Nair,Carsten Wittekindt,Dominik Marx.  (2011-05-13)  Peptide synthesis in aqueous environments: the role of extreme conditions and pyrite mineral surfaces on formation and hydrolysis of peptides..  Journal of the American Chemical Society,  133  ((21)): (8216-8226).  [PMID:21561111]
7. Mark A Milanick,Sarah Ritter,Kenith Meissner.  (2011-06-07)  Engineering erythrocytes to be erythrosensors: first steps..  Blood cells, molecules & diseases,  47  ((2)): (100-106).  [PMID:21641241]
8. Yung-Fou Chen,J J Dannenberg.  (2011-07-01)  The effect of polarization on multiple hydrogen-bond formation in models of self-assembling materials..  Journal of computational chemistry,  32  ((13)): (2890-2895).  [PMID:21717481]
9. Alessandro Pedretti,Laura De Luca,Cristina Marconi,Luca Regazzoni,Giancarlo Aldini,Giulio Vistoli.  (2011-07-12)  Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping..  Bioorganic & medicinal chemistry,  19  ((15)): (4544-4551).  [PMID:21741846]
10. P B Armentrout,Amy L Heaton.  (2011-09-29)  Thermodynamics and mechanisms of protonated diglycine decomposition: a guided ion beam study..  Journal of the American Society for Mass Spectrometry,  23  ((4)): (632-643).  [PMID:21952768]
11. Christopher M Leavitt,Arron B Wolk,Michael Z Kamrath,Etienne Garand,Michael J Van Stipdonk,Mark A Johnson.  (2011-09-29)  Characterizing the intramolecular H-bond and secondary structure in methylated GlyGlyH+ with H2 predissociation spectroscopy..  Journal of the American Society for Mass Spectrometry,  22  ((11)): (1941-1952).  [PMID:21952771]
12. Helen Giamarellou,Garyphallia Poulakou.  (2011-10-01)  Pharmacokinetic and pharmacodynamic evaluation of tigecycline..  Expert opinion on drug metabolism & toxicology,  ((11)): (1459-1470).  [PMID:21958044]
13. Daniel H Haft,Neha Varghese.  (2011-12-24)  GlyGly-CTERM and rhombosortase: a C-terminal protein processing signal in a many-to-one pairing with a rhomboid family intramembrane serine protease..  PloS one,  ((12)): (e28886-e28886).  [PMID:22194940]
14. Celedonio M Álvarez,Raúl García-Rodríguez,Daniel Miguel.  (2012-02-15)  Iminopyridine complexes of manganese, rhenium, and molybdenum derived from amino ester methylserine and peptides Gly-Gly, Gly-Val, and Gly-Gly-Gly: self-assembly of the peptide chains..  Inorganic chemistry,  51  ((5)): (2984-2996).  [PMID:22329711]
15. Sartaj Tabassum,Waddhaah M Al-Asbahy,Mohd Afzal,Farukh Arjmand,Vivek Bagchi.  (2012-03-13)  Molecular drug design, synthesis and structure elucidation of a new specific target peptide based metallo drug for cancer chemotherapy as topoisomerase I inhibitor..  Dalton transactions (Cambridge, England : 2003),  41  ((16)): (4955-4964).  [PMID:22407358]
16. Cheng Zhang,Jianpeng Ma.  (2012-06-07)  Estimating statistical distributions using an integral identity..  The Journal of chemical physics,  136  ((20)): (204113-204113).  [PMID:22667546]
17. N Ranjana Devi,Bimola Huidrom,N Rajmuhon Singh.  (2012-06-23)  Studies on the complexation of Pr(III) and Nd(III) with glycyl-glycine (gly-gly) using spectral analysis of 4f-4f transitions and potentiometric titrations..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  96  (370-379).  [PMID:22722070]
18. Daisy Bustos,Corey E Bakalarski,Yanling Yang,Junmin Peng,Donald S Kirkpatrick.  (2012-06-26)  Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment..  Molecular & cellular proteomics : MCP,  11  ((12)): (1529-1540).  [PMID:22729469]
19. Koji Yamada,Miyuki Muramatsu,Daiki Saito,Mai Sato-Oka,Masayuki Saito,Taishi Moriyama,Hisato Saitoh.  (2012-06-29)  Characterization of the C-terminal diglycine motif of SUMO-1/3..  Bioscience, biotechnology, and biochemistry,  76  ((5)): (1035-1037).  [PMID:22738983]
20. Sebastian A Wagner,Petra Beli,Brian T Weinert,Christian Schölz,Christian D Kelstrup,Clifford Young,Michael L Nielsen,Jesper V Olsen,Cord Brakebusch,Chunaram Choudhary.  (2012-07-14)  Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues..  Molecular & cellular proteomics : MCP,  11  ((12)): (1578-1585).  [PMID:22790023]
21. A Chatterjee,L Zhang,K T Leung.  (2012-08-21)  Bidentate surface structures of glycylglycine on Si(111)7×7 by high-resolution scanning tunneling microscopy: site-specific adsorption via N-H and O-H or double N-H dissociation..  Langmuir : the ACS journal of surfaces and colloids,  28  ((34)): (12502-12508).  [PMID:22900994]
22. Namrata D Udeshi,Tanya Svinkina,Philipp Mertins,Eric Kuhn,D R Mani,Jana W Qiao,Steven A Carr.  (2012-12-26)  Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments..  Molecular & cellular proteomics : MCP,  12  ((3)): (825-831).  [PMID:23266961]
23. Lasse Jenner,Agata L Starosta,Daniel S Terry,Aleksandra Mikolajka,Liudmila Filonava,Marat Yusupov,Scott C Blanchard,Daniel N Wilson,Gulnara Yusupova.  (2013-02-23)  Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis..  Proceedings of the National Academy of Sciences of the United States of America,  110  ((10)): (3812-3816).  [PMID:23431179]
24. Li-Qing Xu,Li-Ping Lu,Miao-Li Zhu.  (2013-04-13)  Analogy to a Chinese knot in an ion-pair copper(II)-neodymium(III) complex based on a hexadentate Schiff base condensation product of 5-bromosalicylaldehyde and glycylglycine..  Acta crystallographica. Section C, Crystal structure communications,  69  ((Pt 4)): (376-379).  [PMID:23579710]
25. Armando Tripodi,Fabio Pellegatta,Veena Chantarangkul,Liliana Grigore,Katia Garlaschelli,Andrea Baragetti,Laura Lemma,Alberico Catapano.  (2014-05-03)  Statins decrease thrombin generation in patients with hypercholesterolemia..  European journal of internal medicine,  25  ((5)): (449-451).  [PMID:24784951]
26. Yan-Chu Chen,Wei-Lun Hsu,Yun-Li Ma,Derek J C Tai,Eminy H Y Lee.  (2014-07-18)  CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory..  The Journal of neuroscience : the official journal of the Society for Neuroscience,  34  ((29)): (9574-9589).  [PMID:25031400]
27. Thanutchaporn Kumrungsee,Tomomi Saiki,Sayaka Akiyama,Kentaro Nakashima,Mitsuru Tanaka,Yutaro Kobayashi,Toshiro Matsui.  (2014-08-06)  Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses..  Biochimica et biophysica acta,  1840  ((10)): (3073-3078).  [PMID:25092650]
28. Francis Impens,Lilliana Radoshevich,Pascale Cossart,David Ribet.  (2014-08-13)  Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli..  Proceedings of the National Academy of Sciences of the United States of America,  111  ((34)): (12432-12437).  [PMID:25114211]
29. Zhe Gao,Yuxiang Ma,Dan Zhao,Xiong Zhang,Hang Zhou,Hailiang Liu,Yang Zhou,Xuefeng Wu,Yan Shen,Yang Sun,Jianxin Li,Xudong Wu,Qiang Xu.  (2014-09-15)  Neochromine S5 improves contact hypersensitivity through a selective effect on activated T lymphocytes..  Biochemical pharmacology,  92  ((2)): (358-368).  [PMID:25218598]
30. Anna-Katharina Wiegers,Heinrich Sticht,Thomas H Winkler,William J Britt,Michael Mach.  (2014-10-17)  Identification of a neutralizing epitope within antigenic domain 5 of glycoprotein B of human cytomegalovirus..  Journal of virology,  89  ((1)): (361-372).  [PMID:25320309]
31. Liyan Hu,Carmen Diez-Fernandez,Véronique Rüfenacht,Burcu Öztürk Hismi,Özlem Ünal,Erdogan Soyucen,Mahmut Çoker,Bilge Tanyeri Bayraktar,Mehmet Gunduz,Ertugrul Kiykim,Asburce Olgac,Jordi Pérez-Tur,Vicente Rubio,Johannes Häberle.  (2014-11-21)  Recurrence of carbamoyl phosphate synthetase 1 (CPS1) deficiency in Turkish patients: characterization of a founder mutation by use of recombinant CPS1 from insect cells expression..  Molecular genetics and metabolism,  113  ((4)): (267-273).  [PMID:25410056]
32. Min Jung Kim,Hee Jin Son,Yiseul Kim,Takumi Misaka,Mee-Ra Rhyu.  (2014-12-10)  Umami-bitter interactions: the suppression of bitterness by umami peptides via human bitter taste receptor..  Biochemical and biophysical research communications,  456  ((2)): (586-590).  [PMID:25490385]
33. Cheng-Han Tsai,Liang-Ting Lin,Chung-Yih Wang,Yu-Wen Chiu,Yen-Ting Chou,Shu-Jun Chiu,Hsin-Ell Wang,Ren-Shyan Liu,Chun-Yi Wu,Pei-Chia Chan,Muh-Hwa Yang,Shih-Hwa Chiou,Man-Jyun Liao,Yi-Jang Lee.  (2015-01-20)  Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA..  Biochimica et biophysica acta,  1852  ((5)): (851-861).  [PMID:25597880]
34. Choon Meng Tan,Meng-Ying Li,Pei-Yun Yang,Shu Heng Chang,Yi-Ping Ho,Hong Lin,Wen-Ling Deng,Jun-Yi Yang.  (2015-02-04)  Arabidopsis HFR1 is a potential nuclear substrate regulated by the Xanthomonas type III effector XopD(Xcc8004)..  PloS one,  10  ((2)): (e0117067-e0117067).  [PMID:25647296]
35. Nicole C Narrandes,Edith Erika Machowski,Valerie Mizrahi,Bavesh D Kana.  (2015-02-06)  Cleavage of the moaX-encoded fused molybdopterin synthase from Mycobacterium tuberculosis is necessary for activity..  BMC microbiology,  15  (22-22).  [PMID:25651977]
36. Radha Thyagarajan,Viqar Banday,Zhoujie Ding,Kristina Lejon.  (2015-02-25)  Contribution of autoallergy to the pathogenesis in the NOD mice..  Autoimmunity,  48  ((5)): (298-304).  [PMID:25707684]
37. Zaheer Ahmed,Ian J Tetlow,Regina Ahmed,Matthew K Morell,Michael J Emes.  (2015-02-26)  Protein-protein interactions among enzymes of starch biosynthesis in high-amylose barley genotypes reveal differential roles of heteromeric enzyme complexes in the synthesis of A and B granules..  Plant science : an international journal of experimental plant biology,  233  (95-106).  [PMID:25711817]
38. Cumali Efe,Mustafa Cengiz,Evrim Kahramanoğlu-Aksoy,Bülent Yilmaz,Burak Özşeker,Yavuz Beyazt,Alpaslan Tanoğlu,Tugrul Purnak,Taylan Kav,Turan Turhan,Seren Ozenirler,Ersan Ozaslan,Staffan Wahlin.  (2015-04-11)  Angiotensin-converting enzyme for noninvasive assessment of liver fibrosis in autoimmune hepatitis..  European journal of gastroenterology & hepatology,  27  ((6)): (649-654).  [PMID:25860719]
39. Patricia E Collins,Gianluca Grassia,Amy Colleran,Patrick A Kiely,Armando Ialenti,Pasquale Maffia,Ruaidhrí J Carmody.  (2015-04-30)  Mapping the Interaction of B Cell Leukemia 3 (BCL-3) and Nuclear Factor κB (NF-κB) p50 Identifies a BCL-3-mimetic Anti-inflammatory Peptide..  The Journal of biological chemistry,  290  ((25)): (15687-15696).  [PMID:25922067]
40. Susanne Andres,Ulf Hansen,Birgit Niemann,Richard Palavinskas,Alfonso Lampen.  (2015-05-30)  Determination of the isoflavone composition and estrogenic activity of commercial dietary supplements based on soy or red clover..  Food & function,  ((6)): (2017-2025).  [PMID:26023053]
41. Gordon Sproul.  (2015-08-08)  Abiogenic Syntheses of Lipoamino Acids and Lipopeptides and their Prebiotic Significance..  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life,  45  ((4)): (427-437).  [PMID:26248658]
42. Katharina Papsdorf,Christoph J O Kaiser,Adrian Drazic,Stefan W Grötzinger,Carmen Haeßner,Wolfgang Eisenreich,Klaus Richter.  (2015-09-04)  Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects..  BMC genomics,  16  (662-662).  [PMID:26335097]
43. Nora Semren,Nunja C Habel-Ungewitter,Isis E Fernandez,Melanie Königshoff,Oliver Eickelberg,Tobias Stöger,Silke Meiners.  (2015-09-05)  Validation of the 2nd Generation Proteasome Inhibitor Oprozomib for Local Therapy of Pulmonary Fibrosis..  PloS one,  10  ((9)): (e0136188-e0136188).  [PMID:26340365]
44. Doori Oh,Seungah Lee,Seong Ho Kang.  (2011-07-14)  Native and fluorescent dye-dependent single-DNA molecule microchip dynamics as measured by differential interference contrast microscopy..  Chemical communications (Cambridge, England),  47  ((32)): (9137-9139).  [PMID:21750823]
45. P B Armentrout,Amy L Heaton.  (2011-09-29)  Thermodynamics and mechanisms of protonated diglycine decomposition: a computational study..  Journal of the American Society for Mass Spectrometry,  23  ((4)): (621-631).  [PMID:21952767]
46. Molly Moravek,Senait Fisseha,Jason E Swain.  (2012-01-17)  Dipeptide forms of glycine support mouse preimplantation embryo development in vitro and provide protection against high media osmolality..  Journal of assisted reproduction and genetics,  29  ((3)): (283-290).  [PMID:22246224]
47. A Antony Joseph,C Ramachandra Raja.  (2012-09-01)  Studies on growth and spectral characterization of diglycine fumarate monohydrate single crystals..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  97  (1120-1124).  [PMID:22935641]
48. Navin Chicooree,Yvonne Connolly,Chong-Teik Tan,Angeliki Malliri,Yaoyong Li,Duncan L Smith,John R Griffiths.  (2013-01-31)  Enhanced detection of ubiquitin isopeptides using reductive methylation..  Journal of the American Society for Mass Spectrometry,  24  ((3)): (421-430).  [PMID:23361369]
49. Steven Breakspear,Masaki Fukuhara,Takashi Itou,Yuji Hirano,Masayoshi Nojiri,Akira Kiyomine,Shigeto Inoue.  (2013-03-02)  Alignment control and softness creation in hair with glycylglycine..  Journal of cosmetic science,  64  ((1)): (19-33).  [PMID:23449128]

Solution Calculators