Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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G131002-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $9.90 | |
G131002-250mg | 250mg | In stock | $16.90 | |
G131002-500mg | 500mg | In stock | $21.90 | |
G131002-1g | 1g | In stock | $29.90 | |
G131002-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $117.90 | |
G131002-25g | 25g | In stock | $469.90 |
Synonyms | Cholylglycine | glycocholate |
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Specifications & Purity | Moligand™, ≥97% |
Biochemical and Physiological Mechanisms | Bile Acid |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Product Description | Glycocholic acid (Glycocholate) is a bile acid with anticancer activity. Glycocholic acid targets against pump resistance-related and non-pump resistance-related pathways. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid |
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INCHI | InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 |
InChi Key | RFDAIACWWDREDC-FRVQLJSFSA-N |
Canonical SMILES | CC(CCC(=O)NCC(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C |
Isomeric SMILES | C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C |
PubChem CID | 10140 |
Molecular Weight | 465.62 |
PubChem CID | 10140 |
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Wikipedia | Glycocholic_acid |
CAS Registry No. | 475-31-0 |
ChEBI | CHEBI:17687 |
ChEMBL Ligand | CHEMBL411070 |
RCSB PDB Ligand | GCH |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K2429536 | Certificate of Analysis | Nov 15, 2024 | G131002 |
K2429535 | Certificate of Analysis | Nov 15, 2024 | G131002 |
K2429534 | Certificate of Analysis | Nov 15, 2024 | G131002 |
K2429533 | Certificate of Analysis | Nov 15, 2024 | G131002 |
H2401132 | Certificate of Analysis | Jul 20, 2024 | G131002 |
H2401133 | Certificate of Analysis | Jul 20, 2024 | G131002 |
H2401131 | Certificate of Analysis | Jul 20, 2024 | G131002 |
H2401130 | Certificate of Analysis | Jul 20, 2024 | G131002 |
H2401129 | Certificate of Analysis | Jul 20, 2024 | G131002 |
H2401098 | Certificate of Analysis | Jul 20, 2024 | G131002 |
H2401078 | Certificate of Analysis | Jul 20, 2024 | G131002 |
H2401077 | Certificate of Analysis | Jul 20, 2024 | G131002 |
F2221332 | Certificate of Analysis | Apr 03, 2024 | G131002 |
F2221330 | Certificate of Analysis | Apr 03, 2024 | G131002 |
F2221329 | Certificate of Analysis | Apr 03, 2024 | G131002 |
F2221317 | Certificate of Analysis | Apr 03, 2024 | G131002 |
A2219160 | Certificate of Analysis | Nov 10, 2023 | G131002 |
J2114565 | Certificate of Analysis | Jul 11, 2023 | G131002 |
J2114569 | Certificate of Analysis | Jul 11, 2023 | G131002 |
J2114570 | Certificate of Analysis | Jul 11, 2023 | G131002 |
J2114571 | Certificate of Analysis | Jul 11, 2023 | G131002 |
J2316062 | Certificate of Analysis | May 30, 2022 | G131002 |
J2316065 | Certificate of Analysis | May 30, 2022 | G131002 |
F2221331 | Certificate of Analysis | May 30, 2022 | G131002 |
Sensitivity | Hygroscopic |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. |
Starting at $72.90
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1. Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, Suizhen Lin, Haiyan Hu. (2023) Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability. Drug Design Development and Therapy, [PMID:27895469] [10.2147/DDDT.S119918] |
2. Chenhui Gu, Xuewen Hu, Baixi Shan, Xiaojing Wu, Jun Chen. (2023) Targeted and non-targeted metabolomics uncovering the effects of Er-Miao-Wan formula on rats with hyperuricemia. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 226 (115246). [PMID:36731256] [10.1016/j.jpba.2023.115246] |
3. Jiating Zheng, Xiaoru Peng, Taifeng Zhu, Shuyao Huang, Chao Chen, Guosheng Chen, Shuqin Liu, Gangfeng Ouyang. (2022) Detection of bile acids in small volume human bile samples via an amino metal-organic framework composite based solid-phase microextraction probe. JOURNAL OF CHROMATOGRAPHY A, 1685 (463634). [PMID:36345074] [10.1016/j.chroma.2022.463634] |
4. Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu. (2023) Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes. CELLULAR SIGNALLING, 101 (110508). [PMID:36341984] [10.1016/j.cellsig.2022.110508] |
5. Wei Xu, Yingying Kong, Tuo Zhang, Zhihua Gong, Wenjun Xiao. (2022) L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (3): (1283-1293). [PMID:36087337] [10.1002/jsfa.12222] |
6. Ma Wen, Yang Bingxin, Li Jun, Liu Mingxia, Li Xianjiang, Liu Huwei. (2022) Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination. MICROCHIMICA ACTA, 189 (7): (1-8). [PMID:35689150] [10.1007/s00604-022-05338-x] |
7. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu. (2022) Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1199 (123249). [PMID:35447521] [10.1016/j.jchromb.2022.123249] |
8. Jinxiu Lyu, Haijuan Li, Dengyang Yin, Meng Zhao, Qiang Sun, Mengzhe Guo. (2021) Analysis of eight bile acids in urine of gastric cancer patients based on covalent organic framework enrichment coupled with liquid chromatography-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1653 (462422). [PMID:34348207] [10.1016/j.chroma.2021.462422] |
9. Weijie Zhang, Yaxin Sun, Shuangyan Wei, Bo Wei, Xia Xu, Youcai Tang. (2021) Untargeted metabolomics reveals the mechanism of quercetin enhancing the bioavailability of ticagrelor. BIOMEDICAL CHROMATOGRAPHY, 35 (12): (e5206). [PMID:34185878] [10.1002/bmc.5206] |
10. Dandan Jiang, Tong Gao, Shuang Liang, Weiwei Mu, Shunli Fu, Yang Liu, Rui Yang, Zipeng Zhang, Yongjun Liu, Na Zhang. (2021) Lymph Node Delivery Strategy Enables the Activation of Cytotoxic T Lymphocytes and Natural Killer Cells to Augment Cancer Immunotherapy. ACS Applied Materials & Interfaces, 13 (19): (22213–22224). [PMID:33955746] [10.1021/acsami.1c03709] |
11. Min Wen, Yubei Liu, Ruiying Chen, Ping He, Feihua Wu, Rui Li, Yining Lin. (2021) Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis. PHYTOTHERAPY RESEARCH, 35 (7): (3799-3811). [PMID:33763888] [10.1002/ptr.7086] |
12. Qin Ni, Chunfang Cai, Shengjie Ren, Junbiao Zhang, Yijun Zhao, Xinyi Wei, Yiyang Ge, Chengrui Wang, Wenjian Li, Ping Wu, Yuantu Ye, Xiamin Cao. (2021) Pectin and soybean meal induce stronger inflammatory responses and dysregulation of bile acid (BA) homeostasis than cellulose and cottonseed meal, respectively, in largemouth bass (Micropterus salmoides), which might be attributed to their BA binding capacity. AQUACULTURE RESEARCH, 52 (7): (2963-2979). [PMID:] [10.1111/are.15140] |
13. Yufei Sun, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Jianlin Wu, Shu Liu. (2021) Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis. PHYTOTHERAPY RESEARCH, 35 (5): (2678-2690). [PMID:33432644] [10.1002/ptr.7014] |
14. Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Xiping Cui, Chunguo Zhang, Huanxin Xiao, Sergei A. Eremin, Yanxiong Fang, Suqing Zhao. (2020) Prussian blue nanoparticles with peroxidase-mimicking properties in a dual immunoassays for glycocholic acid. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 187 (113317). [PMID:32416340] [10.1016/j.jpba.2020.113317] |
15. Wang Xinxin, Feng Yan, Fu Jijun, Wu Cuishuan, He Bing, Zhang Hua, Wang Xueqing, Dai Wenbing, Sun Yong, Zhang Qiang. (2019) A Lipid Micellar System Loaded with Dexamethasone Palmitate Alleviates Rheumatoid Arthritis. AAPS PHARMSCITECH, 20 (8): (1-10). [PMID:31602546] [10.1208/s12249-019-1449-1] |
1. Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, Suizhen Lin, Haiyan Hu. (2023) Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability. Drug Design Development and Therapy, [PMID:27895469] [10.2147/DDDT.S119918] |
2. Chenhui Gu, Xuewen Hu, Baixi Shan, Xiaojing Wu, Jun Chen. (2023) Targeted and non-targeted metabolomics uncovering the effects of Er-Miao-Wan formula on rats with hyperuricemia. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 226 (115246). [PMID:36731256] [10.1016/j.jpba.2023.115246] |
3. Jiating Zheng, Xiaoru Peng, Taifeng Zhu, Shuyao Huang, Chao Chen, Guosheng Chen, Shuqin Liu, Gangfeng Ouyang. (2022) Detection of bile acids in small volume human bile samples via an amino metal-organic framework composite based solid-phase microextraction probe. JOURNAL OF CHROMATOGRAPHY A, 1685 (463634). [PMID:36345074] [10.1016/j.chroma.2022.463634] |
4. Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu. (2023) Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes. CELLULAR SIGNALLING, 101 (110508). [PMID:36341984] [10.1016/j.cellsig.2022.110508] |
5. Wei Xu, Yingying Kong, Tuo Zhang, Zhihua Gong, Wenjun Xiao. (2022) L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (3): (1283-1293). [PMID:36087337] [10.1002/jsfa.12222] |
6. Ma Wen, Yang Bingxin, Li Jun, Liu Mingxia, Li Xianjiang, Liu Huwei. (2022) Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination. MICROCHIMICA ACTA, 189 (7): (1-8). [PMID:35689150] [10.1007/s00604-022-05338-x] |
7. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu. (2022) Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1199 (123249). [PMID:35447521] [10.1016/j.jchromb.2022.123249] |
8. Jinxiu Lyu, Haijuan Li, Dengyang Yin, Meng Zhao, Qiang Sun, Mengzhe Guo. (2021) Analysis of eight bile acids in urine of gastric cancer patients based on covalent organic framework enrichment coupled with liquid chromatography-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1653 (462422). [PMID:34348207] [10.1016/j.chroma.2021.462422] |
9. Weijie Zhang, Yaxin Sun, Shuangyan Wei, Bo Wei, Xia Xu, Youcai Tang. (2021) Untargeted metabolomics reveals the mechanism of quercetin enhancing the bioavailability of ticagrelor. BIOMEDICAL CHROMATOGRAPHY, 35 (12): (e5206). [PMID:34185878] [10.1002/bmc.5206] |
10. Dandan Jiang, Tong Gao, Shuang Liang, Weiwei Mu, Shunli Fu, Yang Liu, Rui Yang, Zipeng Zhang, Yongjun Liu, Na Zhang. (2021) Lymph Node Delivery Strategy Enables the Activation of Cytotoxic T Lymphocytes and Natural Killer Cells to Augment Cancer Immunotherapy. ACS Applied Materials & Interfaces, 13 (19): (22213–22224). [PMID:33955746] [10.1021/acsami.1c03709] |
11. Min Wen, Yubei Liu, Ruiying Chen, Ping He, Feihua Wu, Rui Li, Yining Lin. (2021) Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis. PHYTOTHERAPY RESEARCH, 35 (7): (3799-3811). [PMID:33763888] [10.1002/ptr.7086] |
12. Qin Ni, Chunfang Cai, Shengjie Ren, Junbiao Zhang, Yijun Zhao, Xinyi Wei, Yiyang Ge, Chengrui Wang, Wenjian Li, Ping Wu, Yuantu Ye, Xiamin Cao. (2021) Pectin and soybean meal induce stronger inflammatory responses and dysregulation of bile acid (BA) homeostasis than cellulose and cottonseed meal, respectively, in largemouth bass (Micropterus salmoides), which might be attributed to their BA binding capacity. AQUACULTURE RESEARCH, 52 (7): (2963-2979). [PMID:] [10.1111/are.15140] |
13. Yufei Sun, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Jianlin Wu, Shu Liu. (2021) Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis. PHYTOTHERAPY RESEARCH, 35 (5): (2678-2690). [PMID:33432644] [10.1002/ptr.7014] |
14. Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Xiping Cui, Chunguo Zhang, Huanxin Xiao, Sergei A. Eremin, Yanxiong Fang, Suqing Zhao. (2020) Prussian blue nanoparticles with peroxidase-mimicking properties in a dual immunoassays for glycocholic acid. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 187 (113317). [PMID:32416340] [10.1016/j.jpba.2020.113317] |
15. Wang Xinxin, Feng Yan, Fu Jijun, Wu Cuishuan, He Bing, Zhang Hua, Wang Xueqing, Dai Wenbing, Sun Yong, Zhang Qiang. (2019) A Lipid Micellar System Loaded with Dexamethasone Palmitate Alleviates Rheumatoid Arthritis. AAPS PHARMSCITECH, 20 (8): (1-10). [PMID:31602546] [10.1208/s12249-019-1449-1] |