Glycocholic acid - ≥97%, high purity , CAS No.475-31-0

Item Number
G131002
Grouped product items
SKUSizeAvailabilityPrice Qty
G131002-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$9.90
G131002-250mg
250mg
In stock
$16.90
G131002-500mg
500mg
In stock
$21.90
G131002-1g
1g
In stock
$29.90
G131002-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$117.90
G131002-25g
25g
In stock
$469.90

Basic Description

SynonymsCholylglycine | glycocholate
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsBile Acid
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Product Description

Glycocholic acid (Glycocholate) is a bile acid with anticancer activity. Glycocholic acid targets against pump resistance-related and non-pump resistance-related pathways.

Associated Targets(Human)

GPBAR1 Tchem G-protein coupled bile acid receptor 1 (1723 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1A2 Tchem Solute carrier organic anion transporter family member 1A2 (104 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 (580 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MRP3 Multidrug resistance associated protein (78 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC10 Tbio Multidrug resistance-associated protein 7 (31 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC11 Tbio ATP-binding cassette sub-family C member 11 (24 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus (3973 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus sp. 'group A' (3417 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc10a1 Bile acid transporter (65 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ska Streptokinase A (5805 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc10a2 Ileal sodium/bile acid cotransporter (17 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1c1 Solute carrier organic anion transporter family member 1C1 (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1a5 Solute carrier organic anion transporter family member 1A5 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slco1a3 Solute carrier organic anion transporter family member 1A3 (65 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc10a1 Sodium/bile acid cotransporter (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid
INCHI InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1
InChi Key RFDAIACWWDREDC-FRVQLJSFSA-N
Canonical SMILES CC(CCC(=O)NCC(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
Isomeric SMILES C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C
PubChem CID 10140
Molecular Weight 465.62

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

24 results found

Lot NumberCertificate TypeDateItem
K2429536Certificate of AnalysisNov 15, 2024 G131002
K2429535Certificate of AnalysisNov 15, 2024 G131002
K2429534Certificate of AnalysisNov 15, 2024 G131002
K2429533Certificate of AnalysisNov 15, 2024 G131002
H2401132Certificate of AnalysisJul 20, 2024 G131002
H2401133Certificate of AnalysisJul 20, 2024 G131002
H2401131Certificate of AnalysisJul 20, 2024 G131002
H2401130Certificate of AnalysisJul 20, 2024 G131002
H2401129Certificate of AnalysisJul 20, 2024 G131002
H2401098Certificate of AnalysisJul 20, 2024 G131002
H2401078Certificate of AnalysisJul 20, 2024 G131002
H2401077Certificate of AnalysisJul 20, 2024 G131002
F2221332Certificate of AnalysisApr 03, 2024 G131002
F2221330Certificate of AnalysisApr 03, 2024 G131002
F2221329Certificate of AnalysisApr 03, 2024 G131002
F2221317Certificate of AnalysisApr 03, 2024 G131002
A2219160Certificate of AnalysisNov 10, 2023 G131002
J2114565Certificate of AnalysisJul 11, 2023 G131002
J2114569Certificate of AnalysisJul 11, 2023 G131002
J2114570Certificate of AnalysisJul 11, 2023 G131002
J2114571Certificate of AnalysisJul 11, 2023 G131002
J2316062Certificate of AnalysisMay 30, 2022 G131002
J2316065Certificate of AnalysisMay 30, 2022 G131002
F2221331Certificate of AnalysisMay 30, 2022 G131002

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Chemical and Physical Properties

SensitivityHygroscopic

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P264:Wash hands [and …] thoroughly after handling.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

Related Documents

Citations of This Product

1. Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, Suizhen Lin, Haiyan Hu.  (2023)  Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability.  Drug Design Development and Therapy,      [PMID:27895469] [10.2147/DDDT.S119918]
2. Chenhui Gu, Xuewen Hu, Baixi Shan, Xiaojing Wu, Jun Chen.  (2023)  Targeted and non-targeted metabolomics uncovering the effects of Er-Miao-Wan formula on rats with hyperuricemia.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  226  (115246).  [PMID:36731256] [10.1016/j.jpba.2023.115246]
3. Jiating Zheng, Xiaoru Peng, Taifeng Zhu, Shuyao Huang, Chao Chen, Guosheng Chen, Shuqin Liu, Gangfeng Ouyang.  (2022)  Detection of bile acids in small volume human bile samples via an amino metal-organic framework composite based solid-phase microextraction probe.  JOURNAL OF CHROMATOGRAPHY A,  1685  (463634).  [PMID:36345074] [10.1016/j.chroma.2022.463634]
4. Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu.  (2023)  Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes.  CELLULAR SIGNALLING,  101  (110508).  [PMID:36341984] [10.1016/j.cellsig.2022.110508]
5. Wei Xu, Yingying Kong, Tuo Zhang, Zhihua Gong, Wenjun Xiao.  (2022)  L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  103  (3): (1283-1293).  [PMID:36087337] [10.1002/jsfa.12222]
6. Ma Wen, Yang Bingxin, Li Jun, Liu Mingxia, Li Xianjiang, Liu Huwei.  (2022)  Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination.  MICROCHIMICA ACTA,  189  (7): (1-8).  [PMID:35689150] [10.1007/s00604-022-05338-x]
7. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu.  (2022)  Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1199  (123249).  [PMID:35447521] [10.1016/j.jchromb.2022.123249]
8. Jinxiu Lyu, Haijuan Li, Dengyang Yin, Meng Zhao, Qiang Sun, Mengzhe Guo.  (2021)  Analysis of eight bile acids in urine of gastric cancer patients based on covalent organic framework enrichment coupled with liquid chromatography-tandem mass spectrometry.  JOURNAL OF CHROMATOGRAPHY A,  1653  (462422).  [PMID:34348207] [10.1016/j.chroma.2021.462422]
9. Weijie Zhang, Yaxin Sun, Shuangyan Wei, Bo Wei, Xia Xu, Youcai Tang.  (2021)  Untargeted metabolomics reveals the mechanism of quercetin enhancing the bioavailability of ticagrelor.  BIOMEDICAL CHROMATOGRAPHY,  35  (12): (e5206).  [PMID:34185878] [10.1002/bmc.5206]
10. Dandan Jiang, Tong Gao, Shuang Liang, Weiwei Mu, Shunli Fu, Yang Liu, Rui Yang, Zipeng Zhang, Yongjun Liu, Na Zhang.  (2021)  Lymph Node Delivery Strategy Enables the Activation of Cytotoxic T Lymphocytes and Natural Killer Cells to Augment Cancer Immunotherapy.  ACS Applied Materials & Interfaces,  13  (19): (22213–22224).  [PMID:33955746] [10.1021/acsami.1c03709]
11. Min Wen, Yubei Liu, Ruiying Chen, Ping He, Feihua Wu, Rui Li, Yining Lin.  (2021)  Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis.  PHYTOTHERAPY RESEARCH,  35  (7): (3799-3811).  [PMID:33763888] [10.1002/ptr.7086]
12. Qin Ni, Chunfang Cai, Shengjie Ren, Junbiao Zhang, Yijun Zhao, Xinyi Wei, Yiyang Ge, Chengrui Wang, Wenjian Li, Ping Wu, Yuantu Ye, Xiamin Cao.  (2021)  Pectin and soybean meal induce stronger inflammatory responses and dysregulation of bile acid (BA) homeostasis than cellulose and cottonseed meal, respectively, in largemouth bass (Micropterus salmoides), which might be attributed to their BA binding capacity.  AQUACULTURE RESEARCH,  52  (7): (2963-2979).  [PMID:] [10.1111/are.15140]
13. Yufei Sun, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Jianlin Wu, Shu Liu.  (2021)  Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis.  PHYTOTHERAPY RESEARCH,  35  (5): (2678-2690).  [PMID:33432644] [10.1002/ptr.7014]
14. Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Xiping Cui, Chunguo Zhang, Huanxin Xiao, Sergei A. Eremin, Yanxiong Fang, Suqing Zhao.  (2020)  Prussian blue nanoparticles with peroxidase-mimicking properties in a dual immunoassays for glycocholic acid.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  187  (113317).  [PMID:32416340] [10.1016/j.jpba.2020.113317]
15. Wang Xinxin, Feng Yan, Fu Jijun, Wu Cuishuan, He Bing, Zhang Hua, Wang Xueqing, Dai Wenbing, Sun Yong, Zhang Qiang.  (2019)  A Lipid Micellar System Loaded with Dexamethasone Palmitate Alleviates Rheumatoid Arthritis.  AAPS PHARMSCITECH,  20  (8): (1-10).  [PMID:31602546] [10.1208/s12249-019-1449-1]

References

1. Qin Guo, Jie Cai, Pengyu Li, Dongling Xu, Xiaomin Ni, Hui Wen, Dan Liu, Suizhen Lin, Haiyan Hu.  (2023)  Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability.  Drug Design Development and Therapy,      [PMID:27895469] [10.2147/DDDT.S119918]
2. Chenhui Gu, Xuewen Hu, Baixi Shan, Xiaojing Wu, Jun Chen.  (2023)  Targeted and non-targeted metabolomics uncovering the effects of Er-Miao-Wan formula on rats with hyperuricemia.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  226  (115246).  [PMID:36731256] [10.1016/j.jpba.2023.115246]
3. Jiating Zheng, Xiaoru Peng, Taifeng Zhu, Shuyao Huang, Chao Chen, Guosheng Chen, Shuqin Liu, Gangfeng Ouyang.  (2022)  Detection of bile acids in small volume human bile samples via an amino metal-organic framework composite based solid-phase microextraction probe.  JOURNAL OF CHROMATOGRAPHY A,  1685  (463634).  [PMID:36345074] [10.1016/j.chroma.2022.463634]
4. Zihang Yuan, Jie Wang, Haoran Zhang, Yuanyuan Chai, Yunxia Xu, Yingying Miao, Ziqiao Yuan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu.  (2023)  Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes.  CELLULAR SIGNALLING,  101  (110508).  [PMID:36341984] [10.1016/j.cellsig.2022.110508]
5. Wei Xu, Yingying Kong, Tuo Zhang, Zhihua Gong, Wenjun Xiao.  (2022)  L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  103  (3): (1283-1293).  [PMID:36087337] [10.1002/jsfa.12222]
6. Ma Wen, Yang Bingxin, Li Jun, Liu Mingxia, Li Xianjiang, Liu Huwei.  (2022)  Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination.  MICROCHIMICA ACTA,  189  (7): (1-8).  [PMID:35689150] [10.1007/s00604-022-05338-x]
7. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu.  (2022)  Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1199  (123249).  [PMID:35447521] [10.1016/j.jchromb.2022.123249]
8. Jinxiu Lyu, Haijuan Li, Dengyang Yin, Meng Zhao, Qiang Sun, Mengzhe Guo.  (2021)  Analysis of eight bile acids in urine of gastric cancer patients based on covalent organic framework enrichment coupled with liquid chromatography-tandem mass spectrometry.  JOURNAL OF CHROMATOGRAPHY A,  1653  (462422).  [PMID:34348207] [10.1016/j.chroma.2021.462422]
9. Weijie Zhang, Yaxin Sun, Shuangyan Wei, Bo Wei, Xia Xu, Youcai Tang.  (2021)  Untargeted metabolomics reveals the mechanism of quercetin enhancing the bioavailability of ticagrelor.  BIOMEDICAL CHROMATOGRAPHY,  35  (12): (e5206).  [PMID:34185878] [10.1002/bmc.5206]
10. Dandan Jiang, Tong Gao, Shuang Liang, Weiwei Mu, Shunli Fu, Yang Liu, Rui Yang, Zipeng Zhang, Yongjun Liu, Na Zhang.  (2021)  Lymph Node Delivery Strategy Enables the Activation of Cytotoxic T Lymphocytes and Natural Killer Cells to Augment Cancer Immunotherapy.  ACS Applied Materials & Interfaces,  13  (19): (22213–22224).  [PMID:33955746] [10.1021/acsami.1c03709]
11. Min Wen, Yubei Liu, Ruiying Chen, Ping He, Feihua Wu, Rui Li, Yining Lin.  (2021)  Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis.  PHYTOTHERAPY RESEARCH,  35  (7): (3799-3811).  [PMID:33763888] [10.1002/ptr.7086]
12. Qin Ni, Chunfang Cai, Shengjie Ren, Junbiao Zhang, Yijun Zhao, Xinyi Wei, Yiyang Ge, Chengrui Wang, Wenjian Li, Ping Wu, Yuantu Ye, Xiamin Cao.  (2021)  Pectin and soybean meal induce stronger inflammatory responses and dysregulation of bile acid (BA) homeostasis than cellulose and cottonseed meal, respectively, in largemouth bass (Micropterus salmoides), which might be attributed to their BA binding capacity.  AQUACULTURE RESEARCH,  52  (7): (2963-2979).  [PMID:] [10.1111/are.15140]
13. Yufei Sun, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Jianlin Wu, Shu Liu.  (2021)  Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis.  PHYTOTHERAPY RESEARCH,  35  (5): (2678-2690).  [PMID:33432644] [10.1002/ptr.7014]
14. Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Xiping Cui, Chunguo Zhang, Huanxin Xiao, Sergei A. Eremin, Yanxiong Fang, Suqing Zhao.  (2020)  Prussian blue nanoparticles with peroxidase-mimicking properties in a dual immunoassays for glycocholic acid.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  187  (113317).  [PMID:32416340] [10.1016/j.jpba.2020.113317]
15. Wang Xinxin, Feng Yan, Fu Jijun, Wu Cuishuan, He Bing, Zhang Hua, Wang Xueqing, Dai Wenbing, Sun Yong, Zhang Qiang.  (2019)  A Lipid Micellar System Loaded with Dexamethasone Palmitate Alleviates Rheumatoid Arthritis.  AAPS PHARMSCITECH,  20  (8): (1-10).  [PMID:31602546] [10.1208/s12249-019-1449-1]

Solution Calculators