Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G111375-20mg | 20mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $28.90 |
Synonyms | (3.BETA.,20.BETA.)-20-CARBOXY-11-OXO-30-NOROLEAN-12-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANURONOSYL-.ALPHA.-D-GLUCOPYRANOSIDURONIC ACID | CCRIS 8444 | Glycyrrhetinic acid glycoside | LPLVUJXQOOQHMX-QWBHMCJMSA-N | MFCD00065194 | 18.beta.-glycyrrhizic acid | Glycyr |
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Specifications & Purity | Moligand™, analytical standard |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | analytical standard, Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of OATP1B1;Inhibitor of OATP1B3 |
Product Description | Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
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INCHI | InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1 |
InChi Key | LPLVUJXQOOQHMX-QWBHMCJMSA-N |
Canonical SMILES | CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C |
Isomeric SMILES | C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O |
PubChem CID | 14982 |
Molecular Weight | 822.93 |
Wikipedia | Glycyrrhizin |
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CAS Registry No. | 1405-86-3 |
ChEBI | CHEBI:15939 |
PubChem CID | 14982 |
ChEMBL Ligand | CHEMBL441687 |
DrugCentral Ligand | 1325 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2423256 | Certificate of Analysis | Aug 31, 2024 | G111375 |
A2425296 | Certificate of Analysis | Feb 04, 2024 | G111375 |
A2425306 | Certificate of Analysis | Feb 04, 2024 | G111375 |
F2305266 | Certificate of Analysis | Jun 13, 2023 | G111375 |
L2201716 | Certificate of Analysis | Oct 31, 2022 | G111375 |
G2222273 | Certificate of Analysis | Jul 29, 2022 | G111375 |
Sensitivity | Moisture sensitive |
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Specific Rotation[α] | 61 ° (C=1.5, EtOH) |
Merck Index | 4505 |
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Starting at $43.90
1. Yang Liu, Zhenfeng Wu, Yingchong Chen, Yongmei Guan, Huiwen Guo, Ming Yang, Pengfei Yue. (2023) Rubusoside As a Multifunctional Stabilizer for Novel Nanocrystal-Based Solid Dispersions with a High Drug Loading: A Case Study. JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:37659720] [10.1016/j.xphs.2023.08.024] |
2. Zongjian Sun, Mingxin Zhang, Yanjun Wei, Mengshuang Li, Xianggen Wu, Meng Xin. (2023) A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alkali burns. Biomaterials Science, 11 (7): (2531-2542). [PMID:36779571] [10.1039/D2BM01957D] |
3. Chenxi Wang, Ruyu Yan, Xiaojing Li, Shangyuan Sang, David Julian McClements, Long Chen, Jie Long, Aiquan Jiao, Jinpeng Wang, Chao Qiu, Zhengyu Jin. (2023) Development of emulsion-based edible inks for 3D printing applications: Pickering emulsion gels. FOOD HYDROCOLLOIDS, 138 (108482). [PMID:] [10.1016/j.foodhyd.2023.108482] |
4. Jun Zheng, Xianwen Song, Zhaoyu Yang, Yun Tan, Chao Yin, Jiafu Yin, Yufang Lu, Yufan Yang, Chuntai Liu, Lunzhao Yi, Yi Zhang. (2023) Self-assembling glycyrrhizic acid micellar hydrogels as encapsulant carriers for delivery of curcumin. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 658 (130680). [PMID:] [10.1016/j.colsurfa.2022.130680] |
5. Qiaoyu He, Yumeng Shi, Hong Xing, Qian Tang, Jing Liu, Chunxia Li, Han Zhang, Boli Zhang, Junhua Zhang, Xiaopeng Chen. (2022) Modulating effect of Xuanfei Baidu granule on host metabolism and gut microbiome in rats.. Frontiers in Pharmacology, 13 (922642-922642). [PMID:36147334] [10.3389/fphar.2022.922642] |
6. Yujie Zhang, Min Chen, Shouyong Zhou, Haifeng Han, Mingliang Zhang, Hongdeng Qiu. (2022) A carbonylative coupling approach to alkyl stationary phases with variable embedded carbamate groups for high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, 1661 (462718). [PMID:34875517] [10.1016/j.chroma.2021.462718] |
7. Zhaoyan Zhao, Yuchen Xiao, Lingqing Xu, Ye Liu, Guanmin Jiang, Wei Wang, Bin Li, Tianchuan Zhu, Qingqin Tan, Lantian Tang, Haibo Zhou, Xi Huang, Hong Shan. (2021) Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment. ACS Applied Materials & Interfaces, 13 (18): (20995–21006). [PMID:33930273] [10.1021/acsami.1c02755] |
8. Ting Pan, Yali Lin, Quanzhou Wu, Kaiwen Huang, Jianfeng He. (2020) Preparation of boronate-functionalized surface molecularly imprinted polymer microspheres with polydopamine coating for specific recognition and separation of glycoside template. JOURNAL OF SEPARATION SCIENCE, 44 (12): (2465-2473). [PMID:32367689] [10.1002/jssc.202000125] |
9. Ting Tong, Hongwei Hu, Junwei Zhou, Shuangfei Deng, Xiaotong Zhang, Wantao Tang, Liurong Fang, Shaobo Xiao, Jiangong Liang. (2020) Glycyrrhizic-Acid-Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms. Small, 16 (13): (1906206). [PMID:32077621] [10.1002/smll.201906206] |
10. Qiu Miao, Huang Keqing, Liu Yanzhuo, Yang Yuqing, Tang Honglin, Liu Xiaoxiao, Wang Chenlong, Chen Honglei, Xiong Yu, Zhang Jing, Yang Jing. (2019) Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis. Mucosal Immunology, 12 (4): (945-957). [PMID:30755716] [10.1038/s41385-019-0144-6] |
11. Haixia Li, Dandan Guo, Liangran Zhang, Xiao Feng. (2018) Glycyrrhizin attenuates histamine-mediated MUC5AC upregulation, inflammatory cytokine production, and aquaporin 5 downregulation through suppressing the NF-κB pathway in human nasal epithelial cells. CHEMICO-BIOLOGICAL INTERACTIONS, 285 (21). [PMID:29452068] [10.1016/j.cbi.2018.02.010] |
12. Zhen-Huan Lv, Trinh Anh Phuong, Shi-Jie Jin, Xiao-Xue Li, Ming Xu. (2017) Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes. Oncotarget, 8 (53): ( 91291–91305). [PMID:29207644] [10.18632/oncotarget.20443] |
13. Huang Run-Yue, Chu Yong-Liang, Jiang Ze-Bo, Chen Xiu-Ming, Zhang Xian, Zeng Xing. (2014) Glycyrrhizin Suppresses Lung Adenocarcinoma Cell Growth Through Inhibition of Thromboxane Synthase. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 33 (2): (375-388). [PMID:24556579] [10.1159/000356677] |
1. Yang Liu, Zhenfeng Wu, Yingchong Chen, Yongmei Guan, Huiwen Guo, Ming Yang, Pengfei Yue. (2023) Rubusoside As a Multifunctional Stabilizer for Novel Nanocrystal-Based Solid Dispersions with a High Drug Loading: A Case Study. JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:37659720] [10.1016/j.xphs.2023.08.024] |
2. Zongjian Sun, Mingxin Zhang, Yanjun Wei, Mengshuang Li, Xianggen Wu, Meng Xin. (2023) A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alkali burns. Biomaterials Science, 11 (7): (2531-2542). [PMID:36779571] [10.1039/D2BM01957D] |
3. Chenxi Wang, Ruyu Yan, Xiaojing Li, Shangyuan Sang, David Julian McClements, Long Chen, Jie Long, Aiquan Jiao, Jinpeng Wang, Chao Qiu, Zhengyu Jin. (2023) Development of emulsion-based edible inks for 3D printing applications: Pickering emulsion gels. FOOD HYDROCOLLOIDS, 138 (108482). [PMID:] [10.1016/j.foodhyd.2023.108482] |
4. Jun Zheng, Xianwen Song, Zhaoyu Yang, Yun Tan, Chao Yin, Jiafu Yin, Yufang Lu, Yufan Yang, Chuntai Liu, Lunzhao Yi, Yi Zhang. (2023) Self-assembling glycyrrhizic acid micellar hydrogels as encapsulant carriers for delivery of curcumin. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 658 (130680). [PMID:] [10.1016/j.colsurfa.2022.130680] |
5. Qiaoyu He, Yumeng Shi, Hong Xing, Qian Tang, Jing Liu, Chunxia Li, Han Zhang, Boli Zhang, Junhua Zhang, Xiaopeng Chen. (2022) Modulating effect of Xuanfei Baidu granule on host metabolism and gut microbiome in rats.. Frontiers in Pharmacology, 13 (922642-922642). [PMID:36147334] [10.3389/fphar.2022.922642] |
6. Yujie Zhang, Min Chen, Shouyong Zhou, Haifeng Han, Mingliang Zhang, Hongdeng Qiu. (2022) A carbonylative coupling approach to alkyl stationary phases with variable embedded carbamate groups for high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, 1661 (462718). [PMID:34875517] [10.1016/j.chroma.2021.462718] |
7. Zhaoyan Zhao, Yuchen Xiao, Lingqing Xu, Ye Liu, Guanmin Jiang, Wei Wang, Bin Li, Tianchuan Zhu, Qingqin Tan, Lantian Tang, Haibo Zhou, Xi Huang, Hong Shan. (2021) Glycyrrhizic Acid Nanoparticles as Antiviral and Anti-inflammatory Agents for COVID-19 Treatment. ACS Applied Materials & Interfaces, 13 (18): (20995–21006). [PMID:33930273] [10.1021/acsami.1c02755] |
8. Ting Pan, Yali Lin, Quanzhou Wu, Kaiwen Huang, Jianfeng He. (2020) Preparation of boronate-functionalized surface molecularly imprinted polymer microspheres with polydopamine coating for specific recognition and separation of glycoside template. JOURNAL OF SEPARATION SCIENCE, 44 (12): (2465-2473). [PMID:32367689] [10.1002/jssc.202000125] |
9. Ting Tong, Hongwei Hu, Junwei Zhou, Shuangfei Deng, Xiaotong Zhang, Wantao Tang, Liurong Fang, Shaobo Xiao, Jiangong Liang. (2020) Glycyrrhizic-Acid-Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms. Small, 16 (13): (1906206). [PMID:32077621] [10.1002/smll.201906206] |
10. Qiu Miao, Huang Keqing, Liu Yanzhuo, Yang Yuqing, Tang Honglin, Liu Xiaoxiao, Wang Chenlong, Chen Honglei, Xiong Yu, Zhang Jing, Yang Jing. (2019) Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis. Mucosal Immunology, 12 (4): (945-957). [PMID:30755716] [10.1038/s41385-019-0144-6] |
11. Haixia Li, Dandan Guo, Liangran Zhang, Xiao Feng. (2018) Glycyrrhizin attenuates histamine-mediated MUC5AC upregulation, inflammatory cytokine production, and aquaporin 5 downregulation through suppressing the NF-κB pathway in human nasal epithelial cells. CHEMICO-BIOLOGICAL INTERACTIONS, 285 (21). [PMID:29452068] [10.1016/j.cbi.2018.02.010] |
12. Zhen-Huan Lv, Trinh Anh Phuong, Shi-Jie Jin, Xiao-Xue Li, Ming Xu. (2017) Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes. Oncotarget, 8 (53): ( 91291–91305). [PMID:29207644] [10.18632/oncotarget.20443] |
13. Huang Run-Yue, Chu Yong-Liang, Jiang Ze-Bo, Chen Xiu-Ming, Zhang Xian, Zeng Xing. (2014) Glycyrrhizin Suppresses Lung Adenocarcinoma Cell Growth Through Inhibition of Thromboxane Synthase. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 33 (2): (375-388). [PMID:24556579] [10.1159/000356677] |