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GNE-064 , CAS No.G610610, Inhibitor of polybromo 1;Inhibitor of SWI/SNF related; matrix associated; actin dependent regulator of chromatin; subfamily a; member 2;Inhibitor of SWI/SNF related; matrix associated; actin dependent regulator of chromatin; subfamily a; member 4

Item Number
G610610
Grouped product items
SKUSizeAvailabilityPrice Qty
G610610-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
G610610-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
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polybromo 1 Inhibitor SWI/SNF related，matrix associated，actin dependent regulator of chromatin，subfamily a，member 2 Inhibitor SWI/SNF related，matrix associated，actin dependent regulator of chromatin，subfamily a，member 4 Inhibitor

Basic Description

Synonymscompound 5;GNE064
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of polybromo 1;Inhibitor of SWI/SNF related; matrix associated; actin dependent regulator of chromatin; subfamily a; member 2;Inhibitor of SWI/SNF related; matrix associated; actin dependent regulator of chromatin; subfamily a; member 4

Associated Targets(Human)

SMARCA4 Tchem Transcription activator BRG1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SMARCA2 Tchem Probable global transcription activator SNF2L2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PBRM1 Tchem Protein polybromo-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C8 Tchem Cytochrome P450 2C8 (1492 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PBRM1 Tchem Protein polybromo-1 (712 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMARCA2 Tchem Probable global transcription activator SNF2L2 (466 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1-[(2R)-4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]-2-methylpiperazin-1-yl]ethanone
INCHI InChI=1S/C17H21N5O2/c1-11-10-21(7-8-22(11)12(2)23)15-9-14(19-20-17(15)18)13-5-3-4-6-16(13)24/h3-6,9,11,24H,7-8,10H2,1-2H3,(H2,18,20)/t11-/m1/s1
InChi Key FHRKRGDHMCCDEO-LLVKDONJSA-N
Canonical SMILES C[C@@H]1CN(CCN1C(=O)C)c1cc(nnc1N)c1ccccc1O
Isomeric SMILES C[C@@H]1CN(CCN1C(=O)C)C2=CC(=NN=C2N)C3=CC=CC=C3O
PubChem CID 137029447

Certificates

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Related Documents

 SDS

 Specification Sheet

References

1. Taylor AM, Bailey C, Belmont LD, Campbell R, Cantone N, Côté A, Crawford TD, Cummings R, DeMent K, Duplessis M et al..  (2022)  GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1..  J Med Chem,  65  (16): (11177-11186).  [PMID:35930799] [10.1021/op500134e]

Solution Calculators

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