GNE-0877 - 98%, high purity , CAS No.1374828-69-9, Inhibitor of leucine rich repeat kinase 2

Item Number
G355276
Grouped product items
SKUSizeAvailabilityPrice Qty
G355276-1mg
1mg
In stock
$35.90
G355276-5mg
5mg
In stock
$147.90
G355276-25mg
25mg
In stock
$484.90
G355276-50mg
50mg
In stock
$761.90

Basic Description

SynonymsBCP09654 | CCG-267909 | compound 11 [PMID: 24354345] | SY275739 | AT19318 | GTPL9393 | TVT | 1H-PYRAZOLE-1-ACETONITRILE, .ALPHA.,.ALPHA.,3-TRIMETHYL-4-((4-(METHYLAMINO)-5-(TRIFLUOROMETHYL)-2-PYRIMIDINYL)AMINO)- | MS-25163 | ANGHS285FG | 2-Methyl-2-[3-meth
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of leucine rich repeat kinase 2

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LRRK2 Tchem Leucine-rich repeat serine/threonine-protein kinase 2 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KA6 Tchem Ribosomal protein S6 kinase alpha 6 (2027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KA2 Tchem Ribosomal protein S6 kinase alpha 2 (2184 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPS6KA3 Tchem Ribosomal protein S6 kinase alpha 3 (4284 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2B6 Tchem Cytochrome P450 2B6 (1338 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TTK Tchem Dual specificity protein kinase TTK (2978 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LRRK2 Tchem Leucine-rich repeat serine/threonine-protein kinase 2 (6390 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cynomolgus monkey (4946 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsome (341 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORALA2185Serine/threonine-protein kinase Aurora-BSINGLE PROTEINHomo sapiens

Other: [1]


Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORALA2185Serine/threonine-protein kinase Aurora-BSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORALA2185Serine/threonine-protein kinase Aurora-BSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORALA2185Serine/threonine-protein kinase Aurora-BSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORALA2185Serine/threonine-protein kinase Aurora-BSINGLE PROTEINHomo sapiens

PubMed: [1]


Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORALA2185Serine/threonine-protein kinase Aurora-BSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORALA2185Serine/threonine-protein kinase Aurora-BSINGLE PROTEINHomo sapiens

Other: [1]


PubMed: [1]


Wikipedia: [1]


Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORALA2185Serine/threonine-protein kinase Aurora-BSINGLE PROTEINHomo sapiens

Other: [1]


PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORALA2185Serine/threonine-protein kinase Aurora-BSINGLE PROTEINHomo sapiens

PubMed: [1]


Cytochrome P450 3A4 inhibitorINHIBITORALA340Cytochrome P450 3A4SINGLE PROTEINHomo sapiens

PubMed: [1]


Wikipedia: [1]


Names and Identifiers

IUPAC Name 2-methyl-2-[3-methyl-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]pyrazol-1-yl]propanenitrile
INCHI InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
InChi Key ZPPUMAMZIMPJGP-UHFFFAOYSA-N
Canonical SMILES CC1=NN(C=C1NC2=NC=C(C(=N2)NC)C(F)(F)F)C(C)(C)C#N
Isomeric SMILES CC1=NN(C=C1NC2=NC=C(C(=N2)NC)C(F)(F)F)C(C)(C)C#N
Alternate CAS 1374828-69-9
PubChem CID 69093374
MeSH Entry Terms 2-methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanenitrile;GNE-0877
Molecular Weight 339.32

Certificates

C of A & Other Certificates

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
I2220409Certificate of AnalysisJul 14, 2022 G355276
I2220410Certificate of AnalysisJul 14, 2022 G355276
I2220411Certificate of AnalysisJul 14, 2022 G355276
I2220492Certificate of AnalysisJul 14, 2022 G355276

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H319:Causes serious eye irritation

H317:May cause an allergic skin reaction

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

Related Documents

References

1. Jennings D, Huntwork-Rodriguez S, Henry AG, Sasaki JC, Meisner R, Diaz D, Solanoy H, Wang X, Negrou E, Bondar VV et al..  (2022)  Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease..  Sci Transl Med,  14  (648): (eabj2658).  [PMID:35675433] [10.1126/scitranslmed.abj2658]

Solution Calculators