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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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G647724-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $780.90 | |
G647724-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,250.90 |
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR , with an EC 50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR , with an EC 50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. In Vitro GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC 50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:NMDA Receptor |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (1R,2R)-2-[7-chloro-2-[[5-chloro-3-(trifluoromethyl)pyrazol-1-yl]methyl]-4-oxopyrido[1,2-a]pyrimidin-6-yl]cyclopropane-1-carbonitrile |
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INCHI | InChI=1S/C17H10Cl2F3N5O/c18-11-1-2-14-24-9(7-26-13(19)5-12(25-26)17(20,21)22)4-15(28)27(14)16(11)10-3-8(10)6-23/h1-2,4-5,8,10H,3,7H2/t8-,10+/m0/s1 |
InChi Key | GPMGDUIAVSFGGH-WCBMZHEXSA-N |
Canonical SMILES | C1C(C1C2=C(C=CC3=NC(=CC(=O)N32)CN4C(=CC(=N4)C(F)(F)F)Cl)Cl)C#N |
Isomeric SMILES | C1[C@H]([C@@H]1C2=C(C=CC3=NC(=CC(=O)N32)CN4C(=CC(=N4)C(F)(F)F)Cl)Cl)C#N |
PubChem CID | 122630795 |
Molecular Weight | 428.20 |
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Solubility | DMSO : 100 mg/mL (233.54 mM; Need ultrasonic) |
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