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GNE-617 - 10mM in DMSO, high purity , CAS No.1362154-70-8
Basic Description
| Specifications & Purity | 10mM in DMSO |
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| Biochemical and Physiological Mechanisms | GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM. |
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| Storage Temp | Store at -80°C |
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| Shipped In | Ice chest + Ice pads |
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| Product Description | Information GNE-617 GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM. Targets NAMPT (Cell-free assay) 5 nM |
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Product Properties
| ALogP | 2.875 |
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| HBD Count | 1 |
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| Rotatable Bond | 5 |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | N-[[4-(3,5-difluorophenyl)sulfonylphenyl]methyl]imidazo[1,2-a]pyridine-6-carboxamide |
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| INCHI | InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27) |
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| InChi Key | XRDVXQQZLHVEQZ-UHFFFAOYSA-N |
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| Canonical SMILES | C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F |
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| Isomeric SMILES | C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F |
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| PubChem CID | 68277611 |
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| Molecular Weight | 427.42 |
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Chemical and Physical Properties
| DMSO(mg / mL) Max Solubility | 42 |
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| DMSO(mM) Max Solubility | 98.2640026203734 |
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| Water(mg / mL) Max Solubility | ＜1 |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
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