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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G126166-5mg | 5mg | In stock | $75.90 | |
G126166-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $342.90 | |
G126166-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $489.90 | |
G126166-250mg | 250mg | In stock | $2,205.90 |
Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
Synonyms | HMS3265C23 | Bcr-abl inhibitor GNF-2 | HMS3333I20 | SB19395 | SW219739-1 | 3-[6-(4-trifluoromethoxyphenyl-amino)-pyrimidin-4-yl]-benzamide | BDBM50325999 | GNF 2 | Q27074949 | A865149 | Rayon Fast Black B | STJ | AS-16705 | Bcr-abl Inhibitor - CAS 778270- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50= 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | 卖完停产,不再备货 |
Product Description | GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide |
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INCHI | InChI=1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25) |
InChi Key | WEVYNIUIFUYDGI-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC(=C1)C(=O)N)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F |
Isomeric SMILES | C1=CC(=CC(=C1)C(=O)N)C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F |
WGK Germany | 3 |
PubChem CID | 5311510 |
Molecular Weight | 374.32 |
PubChem CID | 5311510 |
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ChEMBL Ligand | CHEMBL483847 |
CAS Registry No. | 778270-11-4 |
RCSB PDB Ligand | STJ |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H1519083 | Certificate of Analysis | Mar 16, 2023 | G126166 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 37.43, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 18.72, Max Conc. mM: 50 |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
1. Adrián FJ, Ding Q, Sim T, Velentza A, Sloan C, Liu Y, Zhang G, Hur W, Ding S, Manley P et al.. (2006) Allosteric inhibitors of Bcr-abl-dependent cell proliferation.. Nat Chem Biol, 2 (2): (95-102). [PMID:16415863] [10.1021/op500134e] |