Go 6976 - 98%, high purity , CAS No.136194-77-9, Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of protein kinase C alpha;Inhibitor of protein kinase D1

Item Number

G276069

• Synonyms: GO6976 | Go-6976 | 3-(13-Methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile | Goe 6976 | 5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile | B9IQO7JZ16
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Potent, selective PKC inhibitor (IC 50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca 2+ -dependent PKC isoforms over Ca 2+ -independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in viv
• Storage Temp: Store at -20°C,Desiccated
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of protein kinase C alpha;Inhibitor of protein kinase D1
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.