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SKU | Size | Availability | Price | Qty |
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G421374-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $188.90 |
Potent PKC inhibitor. Selective for PKCα and PKCβ
Synonyms | 136194-77-9 | Go 6976 | GO6976 | Go-6976 | Goe 6976 | 3-(13-Methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile | 5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile | B9IQO7JZ16 | 12-(2-Cya |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Potent, selective PKC inhibitor (IC 50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca 2+ -dependent PKC isoforms over Ca 2+ -independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in viv |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-(23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-3-yl)propanenitrile |
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INCHI | InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) |
InChi Key | VWVYILCFSYNJHF-UHFFFAOYSA-N |
Canonical SMILES | CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O |
Isomeric SMILES | CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O |
PubChem CID | 3501 |
Molecular Weight | 378.43 |
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