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GPR4 antagonist 3b , CAS No.G610633, Antagonist of GPR4

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GPR4 antagonist 3b , CAS No.G610633, Antagonist of GPR4

Moligand™

PubChem CID: 127043060

Item Number

G610633

Grouped product items
SKU	Size	Availability	Price	Qty
G610633-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
G610633-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

GPR4 Antagonist

Basic Description

Synonyms	compound 3b
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of GPR4

Associated Targets(Human)

GPR4 Tchem G-protein coupled receptor 4 (2 Activities)

Discover Target: GPR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR4 Tchem G-protein coupled receptor 4 (124 Activities)

Discover Target: GPR4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GPR68 Tchem Ovarian cancer G-protein coupled receptor 1 (279 Activities)

Discover Target: GPR68

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GPR65 Tbio Psychosine receptor (13 Activities)

Discover Target: GPR65

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	3-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-8-(piperidin-1-ylmethyl)-6,11-dihydro-5~{H}-benzo[b][1]benzazepine
INCHI	InChI=1S/C31H37N5/c1-4-29-34-30-21(2)16-22(3)32-31(30)36(29)20-24-9-13-28-26(18-24)11-10-25-17-23(8-12-27(25)33-28)19-35-14-6-5-7-15-35/h8-9,12-13,16-18,33H,4-7,10-11,14-15,19-20H2,1-3H3
InChi Key	YFBWGDXTUXTMEM-UHFFFAOYSA-N
Canonical SMILES	CCc1nc2c(n1Cc1ccc3c(c1)CCc1c(N3)ccc(c1)CN1CCCCC1)nc(cc2C)C
Isomeric SMILES	CCC1=NC2=C(N1CC3=CC4=C(C=C3)NC5=C(CC4)C=C(C=C5)CN6CCCCC6)N=C(C=C2C)C
PubChem CID	127043060

Database links

PubChem CID	127043060
ChEMBL Ligand	CHEMBL3810385
BindingDB Ligand	50175290
GPCRdb Ligand	GPR4 antagonist 3b

Certificates

Certificate of Analysis(COA)

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References

1. Fukuda H, Ito S, Watari K, Mogi C, Arisawa M, Okajima F, Kurose H, Shuto S. (2016) Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction.. ACS Med Chem Lett, 7 (5): (493-7). [PMID:27190599]

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