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GR 135531 - 98%, high purity , CAS No.190277-13-5
an agonist of the melatonin MT3 receptors
Basic Description Synonyms Tocris-0896 | BRD-K83023055-001-01-9 | Methyl {3-[2-(Acetylamino)ethyl]-1h-Indol-5-Yl}carbamate | GR 135531 | DTXSID70401560 | CHEBI:93457 | SCHEMBL4655625 | Q27073988 | AKOS024458683 | GR-135531 | GTPL3393 | FT-0671182 | methyl N-[3-(2-acetamidoethyl)-1H Specifications & Purity Moligand™, ≥98% Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Product Description GR 135531 is a putative MEL-1 (melatonin MT3 receptor) agonist, showing low affinity for melatonin receptors MEL-1A-R and MEL-1B-R in the hamster brain. Since GR 135531 binds to MT3 with such high affinity, this compound can be used to discriminate between the melatonin receptor subtypes (MEL-1A-R, MEL-1B-R, and MEL-1(MT3)).
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name methyl N-[3-(2-acetamidoethyl)-1H-indol-5-yl]carbamate INCHI InChI=1S/C14H17N3O3/c1-9(18)15-6-5-10-8-16-13-4-3-11(7-12(10)13)17-14(19)20-2/h3-4,7-8,16H,5-6H2,1-2H3,(H,15,18)(H,17,19) InChi Key MPZVHKLZCUEJFO-UHFFFAOYSA-N Canonical SMILES CC(=O)NCCC1=CNC2=C1C=C(C=C2)NC(=O)OC Isomeric SMILES CC(=O)NCCC1=CNC2=C1C=C(C=C2)NC(=O)OC WGK Germany 3 PubChem CID 4284525 Molecular Weight 275.30
Chemical and Physical Properties Solubility Soluble in ethanol (100 mM), methanol, THF, and DMSO (~28 mg/ml). Insoluble in water. Refractive Index n20D1.64 (Predicted) Boil Point(°C) ~525.2° C at 760 mmHg (Predicted) Melt Point(°C) 204.66° C (Predicted)
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