GR 113808|144625-51-4|GR-113808|GR113808|1H-Indole-3-carboxylic acid, 1-methyl-, (1-(2-((methylsulfonyl)amino)ethyl)-4-piperidinyl)methyl ester|ZT350OYT3I|(1-(2-(Methylsulfonylamino)ethyl)-4-piperidinyl)methyl 1-methyl-1H-indole-3-carboxylate|CHEBI:73380|
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Potent, highly selective 5-HT 4 receptor antagonist (pK b = 8.8). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors. Decreases water intake and potentiates drinking.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of 5-HT 4 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to investigate its effect on calcium (Ca2+) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on nebogenesis in post-embryonic zebrafish
