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GRI 977143 - ≥98%(HPLC), high purity , CAS No.325850-81-5, Agonist of LPA 2 receptor
Selective LPA2receptor non-lipid agonist
Basic Description Synonyms 2-((3-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoicacid | 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid | SCHEMBL15490694 | 2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propylsulfanyl]-benzoic acid | M3L07 Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50= 3.3μM). Does not activate other LPA GPCRs at concentrations up to 10μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activat Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of LPA 2 receptor
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-[3-(1,3-dioxobenzo[de]isoquinolin-2-yl)propylsulfanyl]benzoic acid INCHI InChI=1S/C22H17NO4S/c24-20-16-9-3-6-14-7-4-10-17(19(14)16)21(25)23(20)12-5-13-28-18-11-2-1-8-15(18)22(26)27/h1-4,6-11H,5,12-13H2,(H,26,27) InChi Key GMVZUCHUOYUMLL-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C(=C1)C(=O)O)SCCCN2C(=O)C3=CC=CC4=C3C(=CC=C4)C2=O Isomeric SMILES C1=CC=C(C(=C1)C(=O)O)SCCCN2C(=O)C3=CC=CC4=C3C(=CC=C4)C2=O PubChem CID 3114900 Molecular Weight 391.44
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 39.14, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
Precautionary Statements P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
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H2301181