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GRI 977143 - ≥98%(HPLC), high purity , CAS No.325850-81-5, Agonist of LPA 2 receptor

Moligand™
≥98%(HPLC)

CAS#: 325850-81-5
Formula: C₂₂H₁₇NO₄S
Molecular Weight: 391.44
PubChem CID: 3114900

Item Number

G288503

Grouped product items
SKU	Size	Availability	Price
G288503-5mg	5mg	In stock	$195.90
G288503-10mg	10mg	In stock	$340.90
G288503-25mg	25mg	In stock	$712.90
G288503-50mg	50mg	In stock	$1,136.90
G288503-100mg	100mg	In stock	$1,963.90

Selective LPA2receptor non-lipid agonist

View related series

LPA2 receptor Agonist

Basic Description

Synonyms	325850-81-5\|GRI-977143\|GRI 977143\|GRI977143\|2-((3-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl)thio)benzoic acid\|2-[3-(1,3-dioxobenzo[de]isoquinolin-2-yl)propylsulfanyl]benzoic acid\|M3L07R4ZEP\|CHEMBL3322500\|2-[3-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50= 3.3μM). Does not activate other LPA GPCRs at concentrations up to 10μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activat
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of LPA 2 receptor

Associated Targets

LPAR4 Tchem Lysophosphatidic acid receptor 4 0 Activities

Discover Target: LPAR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LPAR3 Tchem Lysophosphatidic acid receptor 3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LPAR1 Tchem Lysophosphatidic acid receptor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LPAR5 Tchem Lysophosphatidic acid receptor 5 0 Activities

Discover Target: LPAR5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LPAR2 Tchem Lysophosphatidic acid receptor 2 1 Activities

Discover Target: LPAR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[3-(1,3-dioxobenzo[de]isoquinolin-2-yl)propylsulfanyl]benzoic acid
INCHI	InChI=1S/C22H17NO4S/c24-20-16-9-3-6-14-7-4-10-17(19(14)16)21(25)23(20)12-5-13-28-18-11-2-1-8-15(18)22(26)27/h1-4,6-11H,5,12-13H2,(H,26,27)
InChi Key	GMVZUCHUOYUMLL-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C(=C1)C(=O)O)SCCCN2C(=O)C3=CC=CC4=C3C(=CC=C4)C2=O
Isomeric SMILES	C1=CC=C(C(=C1)C(=O)O)SCCCN2C(=O)C3=CC=CC4=C3C(=CC=C4)C2=O
PubChem CID	3114900
Molecular Weight	391.44

CAS Registry No.

325850-81-5

PubChem CID

73755227

GPCRdb Ligand

GRI977143

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
H2301181	Certificate of Analysis	Jul 01, 2023	G288503
H2301185	Certificate of Analysis	Jul 01, 2023	G288503
H2301188	Certificate of Analysis	Jul 01, 2023	G288503
H2301191	Certificate of Analysis	Jul 01, 2023	G288503
H2301193	Certificate of Analysis	Jul 01, 2023	G288503
H2301626	Certificate of Analysis	Jul 01, 2023	G288503
H2301628	Certificate of Analysis	Jul 01, 2023	G288503
H2301647	Certificate of Analysis	Jul 01, 2023	G288503
H2301651	Certificate of Analysis	Jul 01, 2023	G288503
H2301656	Certificate of Analysis	Jul 01, 2023	G288503

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

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