Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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G421095-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $69.90 |
Synonyms | griseofulvin | 126-07-8 | Amudane | (+)-Griseofulvin | Griseofulvinum | Grisactin | Grifulvin | Grisefuline | Griseofulvina | Grisofulvin | Grizeofulvin | Spirofulvin | Grisovin | Lamoryl | Likuden | Fulcin | Grysio | Fulvicin | Griseofulvine | Poncyl | Curling factor | Delmofulvina | Fulvinil | Fulv |
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Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Antifungal. Mode of action: Disrupts the mitotic spindle structure and inhibits nuclear division. Induces apoptosis in human tumor cell lines. |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | An antifungal and antiproliferative agent that affects microtubules. |
ALogP | 2.2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione |
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INCHI | InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1 |
InChi Key | DDUHZTYCFQRHIY-RBHXEPJQSA-N |
Canonical SMILES | CC1CC(=O)C=C(C12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC |
Isomeric SMILES | C[C@@H]1CC(=O)C=C([C@]12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC |
WGK Germany | 3 |
RTECS | WG9800000 |
PubChem CID | 441140 |
Molecular Weight | 352.77 |
Beilstein | 95226 |
Reaxy-Rn | 95226 |
Enter Lot Number to search for COA:
Sensitivity | Heat Sensitive |
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Specific Rotation[α] | 360° (C=1,DMF) |
Melt Point(°C) | 218-224°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H317:May cause an allergic skin reaction H360:May damage fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | WG9800000 |
Reaxy-Rn | 95226 |
Merck Index | 4549 |
1. Yu-Bin Bai, Meng Zhang, Ding Li, Yu Zhao, Liang-Zhu Huang, Jin-Ming Gao. (2023) Synthesis and Antifungal Activity of Derivatives of the Natural Product Griseofulvin against Phytopathogenic Fungi. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (16): (6236–6248). [PMID:37061927] [10.1021/acs.jafc.2c09037] |
2. Ma Lin, Guo Song, Piao Jingshu, Piao Mingguan. (2022) Preparation and Evaluation of a Microsponge Dermal Stratum Corneum Retention Drug Delivery System for Griseofulvin. AAPS PHARMSCITECH, 23 (6): (1-16). [PMID:35854184] [10.1208/s12249-022-02362-1] |
3. Yangjie LI, Jiaying HUANG, Jihui FANG, Zhiye HUANG. (2022) [Fast screening and confirmation of 73 common prohibited compounds in cosmetics by ultra performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry].. Chinese Journal of Chromatography, 40 (5): (433-442). [PMID:35478002] [10.3724/sp.j.1123.2021.09010] |
4. Kamran Bashir, Guoning Chen, Jili Han, Hua Shu, Xia Cui, Lu Wang, Wen Li, Qiang Fu. (2020) Preparation of magnetic metal organic framework and development of solid phase extraction method for simultaneous determination of fluconazole and voriconazole in rat plasma samples by HPLC. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1152 (122201). [PMID:32590216] [10.1016/j.jchromb.2020.122201] |
5. Yu-Bin Bai, Yu-Qi Gao, Xiao-Di Nie, Thi-Mai-Luong Tuong, Ding Li, Jin-Ming Gao. (2019) Antifungal Activity of Griseofulvin Derivatives against Phytopathogenic Fungi in Vitro and in Vivo and Three-Dimensional Quantitative Structure–Activity Relationship Analysis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 67 (22): (6125–6132). [PMID:31083998] [10.1021/acs.jafc.9b00606] |
6. Yangmin Gao, Ping Zhan, Ferry Hagen, Steph B. J. Menken, Jiufeng Sun, Ali Rezaei-Matehkolaei, Sybren de Hoog. (2019) Molecular epidemiology and in vitro antifungal susceptibility of Trichophyton schoenleinii, agent of tinea capitis favosa. MYCOSES, 62 (5): (466-474). [PMID:30597639] [10.1111/myc.12889] |
7. Yue-Hong Yang, Lan-Tao Liu, Mei-Jun Chen, Song Liu, Cheng-Bin Gong, Yu-Bo Wei, Cheuk-Fai Chow, Qian Tang. (2018) A photoresponsive surface molecularly imprinted polymer shell for determination of trace griseofulvin in milk. Materials Science & Engineering C-Materials for Biological Applications, 92 (365). [PMID:30184762] [10.1016/j.msec.2018.06.069] |
1. Yu-Bin Bai, Meng Zhang, Ding Li, Yu Zhao, Liang-Zhu Huang, Jin-Ming Gao. (2023) Synthesis and Antifungal Activity of Derivatives of the Natural Product Griseofulvin against Phytopathogenic Fungi. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (16): (6236–6248). [PMID:37061927] [10.1021/acs.jafc.2c09037] |
2. Ma Lin, Guo Song, Piao Jingshu, Piao Mingguan. (2022) Preparation and Evaluation of a Microsponge Dermal Stratum Corneum Retention Drug Delivery System for Griseofulvin. AAPS PHARMSCITECH, 23 (6): (1-16). [PMID:35854184] [10.1208/s12249-022-02362-1] |
3. Yangjie LI, Jiaying HUANG, Jihui FANG, Zhiye HUANG. (2022) [Fast screening and confirmation of 73 common prohibited compounds in cosmetics by ultra performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry].. Chinese Journal of Chromatography, 40 (5): (433-442). [PMID:35478002] [10.3724/sp.j.1123.2021.09010] |
4. Kamran Bashir, Guoning Chen, Jili Han, Hua Shu, Xia Cui, Lu Wang, Wen Li, Qiang Fu. (2020) Preparation of magnetic metal organic framework and development of solid phase extraction method for simultaneous determination of fluconazole and voriconazole in rat plasma samples by HPLC. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1152 (122201). [PMID:32590216] [10.1016/j.jchromb.2020.122201] |
5. Yu-Bin Bai, Yu-Qi Gao, Xiao-Di Nie, Thi-Mai-Luong Tuong, Ding Li, Jin-Ming Gao. (2019) Antifungal Activity of Griseofulvin Derivatives against Phytopathogenic Fungi in Vitro and in Vivo and Three-Dimensional Quantitative Structure–Activity Relationship Analysis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 67 (22): (6125–6132). [PMID:31083998] [10.1021/acs.jafc.9b00606] |
6. Yangmin Gao, Ping Zhan, Ferry Hagen, Steph B. J. Menken, Jiufeng Sun, Ali Rezaei-Matehkolaei, Sybren de Hoog. (2019) Molecular epidemiology and in vitro antifungal susceptibility of Trichophyton schoenleinii, agent of tinea capitis favosa. MYCOSES, 62 (5): (466-474). [PMID:30597639] [10.1111/myc.12889] |
7. Yue-Hong Yang, Lan-Tao Liu, Mei-Jun Chen, Song Liu, Cheng-Bin Gong, Yu-Bo Wei, Cheuk-Fai Chow, Qian Tang. (2018) A photoresponsive surface molecularly imprinted polymer shell for determination of trace griseofulvin in milk. Materials Science & Engineering C-Materials for Biological Applications, 92 (365). [PMID:30184762] [10.1016/j.msec.2018.06.069] |