| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab106510-10μl | 10μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $66.90 | |
| Ab106510-20μl | 20μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $99.90 | |
| Ab106510-50μl | 50μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $199.90 | |
| Ab106510-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $299.90 | |
| Ab106510-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,299.90 |
pAb; Rabbit anti Human Growth hormone receptor Antibody; WB, IHC; Unconjugated
| Product Name | Growth hormone receptor Antibody - Primary antibody, specific to GHR, Rabbit IgG |
|---|---|
| Synonyms | GH receptor | GHBP | GHR | growth hormone binding protein | Growth Hormone R | growth hormone receptor | serum binding protein | Somatotropin receptor | GH receptor antibody | GH-binding protein antibody | GHBP antibody | GHBP, included antibody | GHR ant |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Azide Free, High performance, Lot by Lot |
| Host species | Rabbit |
| Specificity | GHR |
| Immunogen | Recombinant GHR expressed in E.coli (AA 315-574) |
| Positive Control | WB: A549 cell lysate. IHC: Human liver tissue. |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, High Performance, Validated |
| Product Description | Rabbit anti Human Growth hormone receptor Antibody, Polyclonal, could be used for WB, IHC and so on. Application: WB: 0.01-2µg/mL IHC: 5-30µg/mL Protein Function Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. |
| Isotype | Rabbit IgG |
|---|---|
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Growth hormone receptor Antibody (Ab106510) - Western Blot
All lanes: Growth hormone receptor Antibody (Ab106510) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 72 kDa
Observed band size: 55 kDa
Exposure time: 66.5 s
Growth hormone receptor Antibody (Ab106510) - IHC
DAB staining on IHC
Sample: Human Liver Tissue
Primary Ab: 30 μg/mL Growth hormone receptor Antibody (Ab106510)
Second Ab: 2 µg/mL HRP-LinkedCaprine Anti-Rabbit IgG Polyclonal Antibody.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Application | Dilution info |
|---|---|
| IHC | 5-30 µg/mL |
| WB |
0.01-2 µg/mL
|
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0606834 | Certificate of Analysis | Jun 13, 2024 | Ab106510 |
| ZJ24F0606835 | Certificate of Analysis | Jun 13, 2024 | Ab106510 |
| ZJ24F0606836 | Certificate of Analysis | Jun 13, 2024 | Ab106510 |
| ZJ24F0606837 | Certificate of Analysis | Jun 13, 2024 | Ab106510 |
| 1. Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, Dimaraki EV, Stewart PM, Friend KE, Vance ML et al.. (2000) Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant.. N Engl J Med, 342 (16): (1171-7). [PMID:10770982] |
| 2. de Vos, A M AM, Ultsch, M M and Kossiakoff, A A AA.. (1992) Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.. Science (New York, N.Y.), (17): [PMID:1549776] |
| 3. Urbanek, M M, MacLeod, J N JN, Cooke, N E NE and Liebhaber, S A SA.. (1992) Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript.. Molecular endocrinology (Baltimore, Md.), [PMID:1569971] |
| 4. Fuh, G G and 7 more authors.. (1990) The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain.. The Journal of biological chemistry, (25): [PMID:2406245] |
| 5. Amselem, S S and 6 more authors.. (1989) Laron dwarfism and mutations of the growth hormone-receptor gene.. The New England journal of medicine, (12): [PMID:2779634] |
| 6. Godowski, P J PJ and 9 more authors.. (1989) Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2813379] |
| 7. Leung, D W DW and 8 more authors.. (1987) Growth hormone receptor and serum binding protein: purification, cloning and expression.. Nature, [PMID:2825030] |
| 8. Goddard, A D AD and 8 more authors.. (1995) Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group.. The New England journal of medicine, (26): [PMID:7565946] |
| 9. Duquesnoy, P P and 9 more authors.. (1994) A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization.. The EMBO journal, (15): [PMID:8137822] |
| 10. Urbanek, M M, Russell, J E JE, Cooke, N E NE and Liebhaber, S A SA.. (1993) Functional characterization of the alternatively spliced, placental human growth hormone receptor.. The Journal of biological chemistry, (5): [PMID:8360189] |
| 11. Kou, K K, Lajara, R R and Rotwein, P P.. (1993) Amino acid substitutions in the intracellular part of the growth hormone receptor in a patient with the Laron syndrome.. The Journal of clinical endocrinology and metabolism, [PMID:8421103] |
| 12. Edery, M M and 8 more authors.. (1993) Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism.. The Journal of clinical investigation, [PMID:8450064] |
| 13. Amselem, S S and 6 more authors.. (1993) Spectrum of growth hormone receptor mutations and associated haplotypes in Laron syndrome.. Human molecular genetics, [PMID:8504296] |
| 14. Dastot, F F and 5 more authors.. (1996) Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein.. Proceedings of the National Academy of Sciences of the United States of America, (1): [PMID:8855247] |
| 15. Sundström, M M and 5 more authors.. (1996) Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution.. The Journal of biological chemistry, (13): [PMID:8943276] |
| 16. Sobrier, M L ML and 6 more authors.. (1997) Nine novel growth hormone receptor gene mutations in patients with Laron syndrome.. The Journal of clinical endocrinology and metabolism, [PMID:9024232] |
| 17. Ross, R J RJ and 7 more authors.. (1997) A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein.. Molecular endocrinology (Baltimore, Md.), [PMID:9058373] |
| 18. Amit, T T and 5 more authors.. (1997) A membrane-fixed, truncated isoform of the human growth hormone receptor.. The Journal of clinical endocrinology and metabolism, [PMID:9360546] |
| 19. Walker, J L JL and 6 more authors.. (1998) A novel mutation affecting the interdomain link region of the growth hormone receptor in a Vietnamese girl, and response to long-term treatment with recombinant human insulin-like growth factor-I and luteinizing hormone-releasing hormone analogue.. The Journal of clinical endocrinology and metabolism, [PMID:9661642] |
| 20. Sanchez, J E JE, Perera, E E, Baumbach, L L and Cleveland, W W WW.. (1998) Growth hormone receptor mutations in children with idiopathic short stature.. The Journal of clinical endocrinology and metabolism, [PMID:9814495] |
| 21. Wojcik, J J and 9 more authors.. (1998) Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor.. The Journal of clinical endocrinology and metabolism, [PMID:9851797] |
| 22. Cargill, M M and 17 more authors.. (1999) Characterization of single-nucleotide polymorphisms in coding regions of human genes.. Nature genetics, [PMID:10391209] |
| 23. Pantel, J J and 5 more authors.. (2000) Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution.. The Journal of biological chemistry, (23): [PMID:10764769] |
| 24. Enberg, B B and 5 more authors.. (2000) Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation.. European journal of endocrinology, [PMID:10870033] |
| 25. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352] |
| 26. Conte, Françoise F and 6 more authors.. (2002) Identification of a region critical for proteolysis of the human growth hormone receptor.. Biochemical and biophysical research communications, (18): [PMID:11785980] |
| 27. Takada, Daisuke D and 11 more authors.. (2003) Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred.. American journal of medical genetics. Part A, (30): [PMID:12910492] |
| 28. Jorge, Alexander A L AA, Souza, Silvia C A L SC, Arnhold, Ivo J P IJ and Mendonca, Berenice B BB.. (2004) The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: supression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration.. Clinical endocrinology, [PMID:14678285] |
| 29. Walenkamp, M J E MJ and Wit, J M JM.. (2006) Genetic disorders in the growth hormone - insulin-like growth factor-I axis.. Hormone research, [PMID:16917171] |
| 30. Adriani, Marsilio M and 9 more authors.. (2006) Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:17082603] |
| 31. Choi, Jang Hyun JH and 8 more authors.. (2006) Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B.. Nature cell biology, [PMID:17128263] |
| 32. De Martino, M C MC and 9 more authors.. (2010) The treatment with growth hormone receptor antagonist in acromegaly: effect on vascular structure and function in patients resistant to somatostatin analogues.. Journal of endocrinological investigation, [PMID:20595800] |
| 33. Reh, Christina Southern CS and Geffner, Mitchell E ME.. (2010) Somatotropin in the treatment of growth hormone deficiency and Turner syndrome in pediatric patients: a review.. Clinical pharmacology : advances and applications, [PMID:22291494] |
