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Heat shock proteins
Grp94 inhibitor 54 , CAS No.G610674, Inhibitor of heat shock protein 90 beta family member 1

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Grp94 inhibitor 54 , CAS No.G610674, Inhibitor of heat shock protein 90 beta family member 1

Moligand™

PubChem CID: 137321151

Item Number

G610674

Grouped product items
SKU	Size	Availability	Price	Qty
G610674-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
G610674-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

heat shock protein 90 beta family member 1 Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of heat shock protein 90 beta family member 1

Associated Targets(Human)

HSP90B1 Tchem Endoplasmin (1 Activities)

Discover Target: HSP90B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSP90AA1 Tchem Heat shock protein HSP 90-alpha (4115 Activities)

Discover Target: HSP90AA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HSP90B1 Heat shock protein 90 beta (139 Activities)

Discover Target: HSP90B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4'-(propan-2-yl)-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}-[1,1'-biphenyl]-3-carboxamide
INCHI	InChI=1S/C22H28N2O2/c1-14(2)15-3-5-16(6-4-15)17-7-12-21(20(13-17)22(23)26)24-18-8-10-19(25)11-9-18/h3-7,12-14,18-19,24-25H,8-11H2,1-2H3,(H2,23,26)/t18-,19-
InChi Key	JMGDXIHGWTVBMX-WGSAOQKQSA-N
Canonical SMILES	O[C@@H]1CC[C@H](CC1)Nc1ccc(cc1C(=O)N)c1ccc(cc1)C(C)C
Isomeric SMILES	CC(C)C1=CC=C(C=C1)C2=CC(=C(C=C2)NC3CCC(CC3)O)C(=O)N
PubChem CID	137321151

Database links

PubChem CID	137321151

Certificates

Certificate of Analysis(COA)

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References

1. Jiang F, Guo AP, Xu JC, You QD, Xu XL. (2018) Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.. J Med Chem, 61 (21): (9513-9533). [PMID:30351001] [10.1021/op500134e]

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