Basic Description

Synonyms	1191237-69-0 \| GS-441524 \| GS441524 \| (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile \| GS 441524 \| EVO984 \| EVO-984 \| (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(h
Specifications & Purity	Moligand™
Grade	Moligand™

Associated Targets(Human)

Caco-2 (12174 Activities)

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Calu-3 (339 Activities)

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Huh-7 (12904 Activities)

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MRC5 (9203 Activities)

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MT4 (17854 Activities)

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HEL 299 (144 Activities)

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HEp-2 (3859 Activities)

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Macrophage cell line (190 Activities)

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HeLa (62764 Activities)

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Associated Targets(non-human)

NS5B Hepatitis C virus NS5B RNA-dependent RNA polymerase (3026 Activities)

Discover Target: NS5B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Leishmania infantum (5912 Activities)

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Trypanosoma brucei brucei (13300 Activities)

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Trypanosoma cruzi (99888 Activities)

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Human respirovirus 3 (1674 Activities)

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Human orthopneumovirus (392 Activities)

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Coxsackievirus A21 (10 Activities)

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West Nile virus (623 Activities)

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Yellow fever virus (1530 Activities)

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Hepatitis C virus (23859 Activities)

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Murine hepatitis virus (113 Activities)

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Measles morbillivirus (693 Activities)

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Influenza A virus (11224 Activities)

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Respiratory syncytial virus (3434 Activities)

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Trypanosoma brucei rhodesiense (7991 Activities)

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MDCK (10148 Activities)

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Vero (26788 Activities)

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Human coronavirus 229E (235 Activities)

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dengue virus type 2 (2400 Activities)

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Nipah virus (19 Activities)

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Marburgvirus (118 Activities)

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Middle East respiratory syndrome-related coronavirus (220 Activities)

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SARS-CoV-2 (38078 Activities)

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SARS-CoV (424 Activities)

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Vero C1008 (1716 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

INCHI	InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1
InChi Key	BRDWIEOJOWJCLU-LTGWCKQJSA-N
Canonical SMILES	OC[C@H]1O[C@@]([C@@H]([C@@H]1O)O)(C#N)c1ccc2n1ncnc2N
Isomeric SMILES	C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N
PubChem CID	44468216

Database links

PubChem CID	44468216
ChEMBL Ligand	CHEMBL2016757
RCSB PDB Ligand	U08

Certificates

Certificate of Analysis(COA)

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References

1. Li Y, Cao L, Li G, Cong F, Li Y, Sun J, Luo Y, Chen G, Li G, Wang P et al.. (2021) Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models.. J Med Chem, 71 (13): (1755-70). [PMID:33523654] [10.1021/op500134e]

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SKU	Size	Availability	Price	Qty
G610675-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
G610675-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

GS-441524 , CAS No.G610675

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator