GSA10 - ≥96%, high purity , CAS No.300833-95-8, Allosteric modulator of SMO

Item Number

G275761

Grouped product items
SKU	Size	Availability	Price
G275761-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$375.90
G275761-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$676.90
G275761-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,045.90

Smo receptor agonist

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Basic Description

Synonyms	AS-16537 \| AKOS000624567 \| GTPL10326 \| GSA 10; GSA-10 \| J-017772 \| STK034810 \| 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester \| CS-0011057 \| F82046 \| AG-690/11765216 \| propyl 4-[(1-hexyl-4-hydroxy-2-oxoquinoline-3-car
Specifications & Purity	Moligand™, ≥96%
Biochemical and Physiological Mechanisms	A novel small-molecule Smo receptor agonist. Does not recognize the classic cyclopamine binding site.\xa0May have therapeutic interests in regenerative medicine.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of SMO
Note	Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Shipped at room temperature. Store at -20°C.

Associated Targets(Human)

SMO Tclin Smoothened homolog (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMO Tclin Smoothened homolog (1371 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	propyl 4-[(1-hexyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]benzoate
INCHI	InChI=1S/C26H30N2O5/c1-3-5-6-9-16-28-21-11-8-7-10-20(21)23(29)22(25(28)31)24(30)27-19-14-12-18(13-15-19)26(32)33-17-4-2/h7-8,10-15,29H,3-6,9,16-17H2,1-2H3,(H,27,30)
InChi Key	MDLUYYGRCGDKGL-UHFFFAOYSA-N
Canonical SMILES	CCCCCCN1C2=CC=CC=C2C(=C(C1=O)C(=O)NC3=CC=C(C=C3)C(=O)OCCC)O
Isomeric SMILES	CCCCCCN1C2=CC=CC=C2C(=C(C1=O)C(=O)NC3=CC=C(C=C3)C(=O)OCCC)O
Alternate CAS	300833-95-8
PubChem CID	54683103
Molecular Weight	450.53

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
RIDADR	NONHforallmodesoftransport

References

1. Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A, Manetti F, Solinas A et al.. (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.. Mol Pharmacol, 83 (5): (1020-9). [PMID:23448715] [10.1021/op500134e]

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Basic Description