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GSK 2193874 - 98%, high purity , CAS No.1336960-13-4, Channel blocker of TRPV4
Potent and selective TRPV4 antagonist; orally active
Basic Description Synonyms GSK2193874 | GSK-2193874 | GTPL6465 | NCGC00370767-01 | CS-7612 | 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide | BS-15222 | AC-33151 | SCHEMBL2404540 | BDBM50232797 | 7-bromo-N-(1- Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Potent and selective TRPV4 antagonist (IC50values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarctionin vivomodels. Selective over a pane Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type CHANNEL BLOCKER Mechanism of action Channel blocker of TRPV4
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide INCHI InChI=1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46) InChi Key UIVOZBSCHXCGPS-UHFFFAOYSA-N Canonical SMILES C1CCN(CC1)C2CCN(CC2)CC3=C(C4=C(C=C(C=C4)Br)N=C3C5=CC(=CC=C5)C(F)(F)F)C(=O)NC6(CC6)C7=CC=CC=C7 Isomeric SMILES C1CCN(CC1)C2CCN(CC2)CC3=C(C4=C(C=C(C=C4)Br)N=C3C5=CC(=CC=C5)C(F)(F)F)C(=O)NC6(CC6)C7=CC=CC=C7 Alternate CAS 1336960-13-4 PubChem CID 53464483 MeSH Entry Terms 7-bromo-N-(1-phenylcyclopropyl)-3-((4-piperidin-1-ylpiperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide;GSK2193874 Molecular Weight 691.62
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 34.58, Max Conc. mM: 50
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER/doctor/...
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