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GSK 2194069 - 97%, high purity , CAS No.1332331-08-4, Inhibitor of fatty acid synthase

Item Number
G288292
Grouped product items
SKUSizeAvailabilityPrice Qty
G288292-2mg
2mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
G288292-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
G288292-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$209.90
G288292-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$419.90

Potent human fatty acid synthase (hFASN) inhibitor

Basic Description

SynonymsSCHEMBL2356163 | CAS_80220 | CS-3324 | GSK2194069, >=97% (HPLC) | Q27252830 | 4-[4-(1-benzofuran-5-yl)phenyl]-3-{[(3S)-1-cyclopropanecarbonylpyrrolidin-3-yl]methyl}-4,5-dihydro-1H-1,2,4-triazol-5-one | NCGC00387475-02 | 1332331-08-4 | 2W4 | 4-[4-(1-benzof
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsPotent human fatty acid synthase (hFASN) inhibitor (IC50= 7.7 nM); inhibits hFASβ-ketoacyl reductase activity. Inhibits lipid synthesis and attenuates proliferation of A549 non-small-cell lung cancer cells (EC50= 15 nM)in vitro.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of fatty acid synthase

Associated Targets(Human)

FASN Tchem Fatty acid synthase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FASN Tchem Fatty acid synthase (3390 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4-[4-(1-benzofuran-5-yl)phenyl]-3-[[(3S)-1-(cyclopropanecarbonyl)pyrrolidin-3-yl]methyl]-1H-1,2,4-triazol-5-one
INCHI InChI=1S/C25H24N4O3/c30-24(18-1-2-18)28-11-9-16(15-28)13-23-26-27-25(31)29(23)21-6-3-17(4-7-21)19-5-8-22-20(14-19)10-12-32-22/h3-8,10,12,14,16,18H,1-2,9,11,13,15H2,(H,27,31)/t16-/m0/s1
InChi Key AQTPWCUIYUOEMG-INIZCTEOSA-N
Canonical SMILES C1CC1C(=O)N2CCC(C2)CC3=NNC(=O)N3C4=CC=C(C=C4)C5=CC6=C(C=C5)OC=C6
Isomeric SMILES C1CN(C[C@@H]1CC2=NNC(=O)N2C3=CC=C(C=C3)C4=CC5=C(C=C4)OC=C5)C(=O)C6CC6
PubChem CID 67376285
Molecular Weight 428.48

Certificates

C of A & Other Certificates

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
G2426164Certificate of AnalysisApr 17, 2024 G288292
G2426165Certificate of AnalysisApr 17, 2024 G288292
G2426166Certificate of AnalysisApr 17, 2024 G288292
G2426167Certificate of AnalysisApr 17, 2024 G288292
G2426168Certificate of AnalysisApr 17, 2024 G288292
G2426169Certificate of AnalysisApr 17, 2024 G288292
G2426170Certificate of AnalysisApr 17, 2024 G288292
G2426171Certificate of AnalysisApr 17, 2024 G288292

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 42.85, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 8.57, Max Conc. mM: 20

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

Related Documents

References

1. Hardwicke MA, Rendina AR, Williams SP, Moore ML, Wang L, Krueger JA, Plant RN, Totoritis RD, Zhang G, Briand J et al..  (2014)  A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site..  Nat Chem Biol,  10  (9): (774-9).  [PMID:25086508] [10.1021/op500134e]

Solution Calculators