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GSK 2250665A - ≥97%(HPLC), high purity , CAS No.1246030-96-5
Basic Description Synonyms trans-4-[[4-[(6-Ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]cyclohexanol Specifications & Purity ≥97%(HPLC) Biochemical and Physiological Mechanisms Itk inhibitor (pKi= 9.2). Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC50values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs. Storage Temp Store at 2-8°C Shipped In Wet ice
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 4-[[4-benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]pyrimidin-2-yl]amino]cyclohexan-1-ol INCHI InChI=1S/C26H29N5OS/c1-2-17-8-13-22-23(15-17)33-26(29-22)31-24-16-20(14-18-6-4-3-5-7-18)28-25(30-24)27-19-9-11-21(32)12-10-19/h3-8,13,15-16,19,21,32H,2,9-12,14H2,1H3,(H2,27,28,29,30,31) InChi Key DPRNXTSMYVCYLJ-UHFFFAOYSA-N Canonical SMILES CCC1=CC2=C(C=C1)N=C(S2)NC3=NC(=NC(=C3)CC4=CC=CC=C4)NC5CCC(CC5)O Isomeric SMILES CCC1=CC2=C(C=C1)N=C(S2)NC3=NC(=NC(=C3)CC4=CC=CC=C4)NC5CCC(CC5)O PubChem CID 73352604 Molecular Weight 459.61
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 45.96, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 9.19, Max Conc. mM: 20
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