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GSK 269962 - 10mM in DMSO, high purity , CAS No.850664-21-0
Potent and selective ROCK inhibitor
Basic Description Synonyms GSK269962A|850664-21-0|GSK 269962|GSK-269962A|925213-63-4|GSK269962|GSK 269962A|N-[3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-6-yl]oxyphenyl]-4-(2-morpholin-4-ylethoxy)benzamide|GSK-269962|GSK269962B|Aminofurazanyl-azabenzimidazole 6 Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Potent Rho kinase (ROCK) inhibitor (IC50values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted r Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™
Names and Identifiers IUPAC Name N-[3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-6-yl]oxyphenyl]-4-(2-morpholin-4-ylethoxy)benzamide INCHI InChI=1S/C29H30N8O5/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38) InChi Key YOVNFNXUCOWYSG-UHFFFAOYSA-N Canonical SMILES CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6 Isomeric SMILES CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6 PubChem CID 16095342 Molecular Weight 570.6
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