Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G338805-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $150.90 | |
G338805-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $438.90 | |
G338805-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $790.90 | |
G338805-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,777.90 | |
G338805-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $3,199.90 |
an ATP-binding site inhibitor of GSK-3
Specifications & Purity | Moligand™, ≥98% |
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Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of aurora kinase A;Inhibitor of glycogen synthase kinase 3 beta;Inhibitor of SRC proto-oncogene; non-receptor tyrosine kinase |
Product Description | GSK-3 Inhibitor XIII is an aminopyrazole compound that acts as an ATP-binding site inhibitor of GSK-3. Studies suggest that GSK-3 is a multifunctional serine/threonine kinase involved in estrogen and androgen receptor stability by phosphorylation. GSK-3 can bind to androgen receptors forming complexes in the cytoplasm and nucleus, so inhibition by GSK-3 Inhibitor XIII, will result in a rapid nuclear export of endogenous androgen receptors thus reducing receptors for the enzyme to bind to. |
Ki Data | GSK-3: Ki= 24 nM; Tyrosine-protein kinase SRC: Ki= 81 nM (human) |
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Canonical SMILES | CC1=CC(=NN1)NC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4 |
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Isomeric SMILES | CC1=CC(=NN1)NC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4 |
PubChem CID | 6419766 |
Molecular Weight | 305.3 |
PubChem CID | 6419766 |
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DrugBank Ligand | DB08454 |
ChEMBL Ligand | CHEMBL359482 |
CAS Registry No. | 404828-08-6 |
RCSB PDB Ligand | QPP |
Reactome Reaction | R-HSA-9687724 |
Reactome Drug | R-ALL-9687668 |
Enter Lot Number to search for COA:
Solubility | Soluble in DMSO (5 mg/ml). |
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Refractive Index | n20D1.73 (Predicted) |
Boil Point(°C) | ~456.12° C at 760 (Predicted) |
Melt Point(°C) | 222.82° C (Predicted) |
1. Bebbington D, Binch H, Charrier JD, Everitt S, Fraysse D, Golec J, Kay D, Knegtel R, Mak C, Mazzei F et al.. (2009) The discovery of the potent aurora inhibitor MK-0457 (VX-680).. Bioorg Med Chem Lett, 19 (13): (3586-92). [PMID:19447622] |