Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G287974-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $104.90 | |
G287974-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $160.90 | |
G287974-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $675.90 | |
G287974-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,215.90 |
Selective Rev-Erbα agonist
Synonyms | GSK4112 | 1216744-19-2 | SR6452 | GSK 4112 | GSK-4112 | tert-butyl 2-[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]acetate | Rev-erbalpha agonist GS4112 | CHEMBL1961795 | 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate | t |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, GSK4112 is a small-molecule chemical probe for the cellular biological study of the nuclear heme receptor REV-erbα. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of Rev-Erb-α |
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IUPAC Name | tert-butyl 2-[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]acetate |
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INCHI | InChI=1S/C18H21ClN2O4S/c1-18(2,3)25-17(22)12-20(10-13-4-6-14(19)7-5-13)11-15-8-9-16(26-15)21(23)24/h4-9H,10-12H2,1-3H3 |
InChi Key | WYSLOKHVFKLWOU-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(C)OC(=O)CN(CC1=CC=C(C=C1)Cl)CC2=CC=C(S2)[N+](=O)[O-] |
Isomeric SMILES | CC(C)(C)OC(=O)CN(CC1=CC=C(C=C1)Cl)CC2=CC=C(S2)[N+](=O)[O-] |
PubChem CID | 50905018 |
Molecular Weight | 396.89 |
PubChem CID | 50905018 |
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ChEMBL Ligand | CHEMBL1961795 |
CAS Registry No. | 1216744-19-2 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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A2218456 | Certificate of Analysis | Dec 27, 2021 | G287974 |
A2218460 | Certificate of Analysis | Dec 27, 2021 | G287974 |
A2218461 | Certificate of Analysis | Dec 27, 2021 | G287974 |
A2218464 | Certificate of Analysis | Dec 27, 2021 | G287974 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 9.92, Max Conc. mM: 25 |
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