GSK 4716 - 98%, high purity , CAS No.101574-65-6, Agonist of Estrogen-related receptor-γ

Item Number
G274953
Grouped product items
SKUSizeAvailabilityPrice Qty
G274953-5mg
5mg
In stock
$47.90
G274953-10mg
10mg
In stock
$77.90
G274953-25mg
25mg
In stock
$175.90
G274953-50mg
50mg
In stock
$338.90
G274953-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$599.90

Selective ERRβγ agonist

Basic Description

SynonymsJ-000435 | GSK 4716, >=98% (HPLC) | EN300-6474545 | 2gpp | CHEBI:80000 | A16956 | MFCD00567155 | CS-D0397 | 4-hydroxy-N''-[(1E)-[4-(propan-2-yl)phenyl]methylidene]benzohydrazide | 4-hydroxy-N'-[(E)-[4-(propan-2-yl)phenyl]methylidene]benzohydrazide | HY-33
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsGSK 4716 is an Estrogen-related receptors ERRβ and ERRγ agonist with minimal activity for ERRα, ERα and Erβ
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of Estrogen-related receptor-γ
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at +4°C. The product can be stored for up to 12 months.

Associated Targets(Human)

ESRRG Tchem Estrogen-related receptor gamma (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ESRRA Tchem Estrogen-related receptor alpha (573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESRRG Tchem Estrogen-related receptor gamma (587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Alpha trans-inducing protein (VP16) (945 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-hydroxy-N-[(E)-(4-propan-2-ylphenyl)methylideneamino]benzamide
INCHI InChI=1S/C17H18N2O2/c1-12(2)14-5-3-13(4-6-14)11-18-19-17(21)15-7-9-16(20)10-8-15/h3-12,20H,1-2H3,(H,19,21)/b18-11+
InChi Key IKPPIUNQWSRCOZ-WOJGMQOQSA-N
Canonical SMILES CC(C)C1=CC=C(C=C1)C=NNC(=O)C2=CC=C(C=C2)O
Isomeric SMILES CC(C)C1=CC=C(C=C1)/C=N/NC(=O)C2=CC=C(C=C2)O
PubChem CID 5331325
Molecular Weight 282.34

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
A2206008Certificate of AnalysisJul 12, 2023 G274953
A2206051Certificate of AnalysisJul 12, 2023 G274953
A2206059Certificate of AnalysisJul 12, 2023 G274953
A2206062Certificate of AnalysisJul 12, 2023 G274953
A2206064Certificate of AnalysisJul 12, 2023 G274953

Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM and in ethanol to 100 mM

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H317:May cause an allergic skin reaction

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

Related Documents

Solution Calculators