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GSK 650394 - ≥97%(HPLC), high purity , CAS No.890842-28-1, Inhibitor of serum/glucocorticoid regulated kinase 1;Inhibitor of serum/glucocorticoid regulated kinase 2

Item Number
G287167
Grouped product items
SKUSizeAvailabilityPrice Qty
G287167-5mg
5mg
In stock
$98.90
G287167-10mg
10mg
In stock
$137.90
G287167-25mg
25mg
In stock
$310.90
G287167-50mg
50mg
In stock
$473.90
G287167-100mg
100mg
In stock
$853.90

Serum- and glucocorticoid-regulated kinase (SGK) inhibitor

Basic Description

SynonymsMLS006010262 | CS-1853 | OXAPROZIN [USP-RS] | SMR004701335 | Q27077915 | AC-32637 | AKOS024457693 | HMS3677P22 | NCGC00250410-12 | NCGC00250410-15 | s7209 | FT-0742103 | GSK 650394 | 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid. |
Specifications & PurityMoligand™, ≥97%(HPLC)
Biochemical and Physiological MechanismsSerum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human pros
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of serum/glucocorticoid regulated kinase 1;Inhibitor of serum/glucocorticoid regulated kinase 2
Product Description

Product description:

GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor.

Associated Targets(Human)

SGK2 Tchem Serine/threonine-protein kinase Sgk2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SGK1 Tchem Serine/threonine-protein kinase Sgk1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CAMKK2 Tchem Calcium/calmodulin-dependent protein kinase kinase 2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SGK1 Tchem Serine/threonine-protein kinase Sgk1 (2343 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAMKK1 Tchem CaM-kinase kinase alpha (487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAMKK2 Tchem CaM-kinase kinase beta (1281 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
5637 (630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A 172 (535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A204 (242 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A2058 (690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-375 (9258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-427 (643 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A673 (619 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGS (1999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BT-20 (503 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BT-474 (2113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BXPC-3 (2997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C8166 (1658 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA46 (271 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAKI-1 (44928 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calu-1 (518 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calu-3 (339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calu-6 (398 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAPAN-1 (772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COR-L23 (253 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Daoy (570 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Daudi (625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DMS-79 (150 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DMS-273 (14108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EVSA-T (142 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
G-361 (890 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
G-401 (156 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-1080 (3966 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HuCCT-1 (128 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Huh-7 (12904 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HuTu80 (255 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IM-9 (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J82 (505 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JAR (316 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JIYOYE (162 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LoVo (4724 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M14 (47487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H4 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Camkk2 Calcium/calmodulin-dependent protein kinase kinase 2 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

Other: [1]


Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

PubMed: [1]


Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

PubMed: [1] , [2] , [3]


Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

DOI: [1]


Other: [1]


Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

Other: [1]


PubMed: [1] , [2]


Serine/threonine-protein kinase Aurora-A inhibitorINHIBITORALA4722Serine/threonine-protein kinase Aurora-ASINGLE PROTEINHomo sapiens

PubMed: [1]


Names and Identifiers

Pubchem Sid488200746
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488200746
IUPAC Name 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
INCHI InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
InChi Key WVSBGSNVCDAMCF-UHFFFAOYSA-N
Canonical SMILES C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O
Isomeric SMILES C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O
PubChem CID 25022668
Molecular Weight 382.45

Certificates

C of A & Other Certificates(BSE/TSE, COO)

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
B2301139Certificate of AnalysisNov 21, 2022 G287167
B2301140Certificate of AnalysisNov 21, 2022 G287167
B2301141Certificate of AnalysisNov 21, 2022 G287167
B2301142Certificate of AnalysisNov 21, 2022 G287167
B2301143Certificate of AnalysisNov 21, 2022 G287167
B2301144Certificate of AnalysisNov 21, 2022 G287167
B2301145Certificate of AnalysisNov 21, 2022 G287167
B2301146Certificate of AnalysisNov 21, 2022 G287167
B2301147Certificate of AnalysisNov 21, 2022 G287167
B2301151Certificate of AnalysisNov 21, 2022 G287167

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 38.24, Max Conc. mM: 100

Related Documents

References

1. Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D et al..  (2008)  Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic..  Cancer Res,  68  (18): (7475-83).  [PMID:18794135] [10.1021/op500134e]

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