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SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
G287167-5mg | 5mg | In stock | $98.90 | |
G287167-10mg | 10mg | In stock | $137.90 | |
G287167-25mg | 25mg | In stock | $310.90 | |
G287167-50mg | 50mg | In stock | $473.90 | |
G287167-100mg | 100mg | In stock | $853.90 |
Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
Synonyms | MLS006010262 | CS-1853 | OXAPROZIN [USP-RS] | SMR004701335 | Q27077915 | AC-32637 | AKOS024457693 | HMS3677P22 | NCGC00250410-12 | NCGC00250410-15 | s7209 | FT-0742103 | GSK 650394 | 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid. | |
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Specifications & Purity | Moligand™, ≥97%(HPLC) |
Biochemical and Physiological Mechanisms | Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human pros |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of serum/glucocorticoid regulated kinase 1;Inhibitor of serum/glucocorticoid regulated kinase 2 |
Product Description | Product description: GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | Other: [1] | |
Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | ||
Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | ||
Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | ||
Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | ||
Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | ||
Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | ||
Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | ||
Serine/threonine-protein kinase Aurora-A inhibitor | INHIBITOR | ALA4722 | Serine/threonine-protein kinase Aurora-A | SINGLE PROTEIN | Homo sapiens | PubMed: [1] |
Pubchem Sid | 488200746 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488200746 |
IUPAC Name | 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid |
INCHI | InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29) |
InChi Key | WVSBGSNVCDAMCF-UHFFFAOYSA-N |
Canonical SMILES | C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O |
Isomeric SMILES | C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O |
PubChem CID | 25022668 |
Molecular Weight | 382.45 |
Find and download the COA for your product by matching the lot number on the packaging.
10 results found
Lot Number | Certificate Type | Date | Item |
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Certificate of Analysis | Nov 21, 2022 | G287167 | |
Certificate of Analysis | Nov 21, 2022 | G287167 | |
Certificate of Analysis | Nov 21, 2022 | G287167 | |
Certificate of Analysis | Nov 21, 2022 | G287167 | |
Certificate of Analysis | Nov 21, 2022 | G287167 | |
Certificate of Analysis | Nov 21, 2022 | G287167 | |
Certificate of Analysis | Nov 21, 2022 | G287167 | |
Certificate of Analysis | Nov 21, 2022 | G287167 | |
Certificate of Analysis | Nov 21, 2022 | G287167 | |
Certificate of Analysis | Nov 21, 2022 | G287167 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 38.24, Max Conc. mM: 100 |
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1. Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D et al.. (2008) Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.. Cancer Res, 68 (18): (7475-83). [PMID:18794135] [10.1021/op500134e] |