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GSK 650394 - 10mM in DMSO, high purity , CAS No.890842-28-1
Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
Basic Description Synonyms 890842-28-1 | GSK 650394 | GSK650394 | GSK-650394 | 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid | CHEMBL558642 | 56887611DJ | 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid | Benzoic acid, 2-cyclopentyl-4-(5-phenyl-1H-pyrrol Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human pros Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid INCHI InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29) InChi Key WVSBGSNVCDAMCF-UHFFFAOYSA-N Canonical SMILES C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O Isomeric SMILES C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O PubChem CID 25022668 Molecular Weight 382.45
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