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GSK-7975A , CAS No.1253186-56-9, Channel blocker of Orai1;Channel blocker of Orai2

CAS#: 1253186-56-9
Formula: C₁₈H₁₂F₅N₃O₂
Molecular Weight: 397.3
PubChem CID: 59547990

Item Number

G610729

Grouped product items
SKU	Size	Availability	Price	Qty
G610729-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
G610729-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

Orai1 Channel blocker Orai2 Channel blocker

Synonyms

example 36 [US20120053150A1];GSK7975A

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

CHANNEL BLOCKER

Mechanism of action

Channel blocker of Orai1;Channel blocker of Orai2

Associated Targets(Human)

ORAI1 Tchem Calcium release-activated calcium channel protein 1 (1 Activities)

Discover Target: ORAI1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ORAI2 Tchem Protein orai-2 (1 Activities)

Discover Target: ORAI2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ORAI1 Tchem ORAI1/STIM1 (242 Activities)

Discover Target: ORAI1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ORAI3 Tbio Stromal interaction molecule 1/Protein orai-3 (1 Activities)

Discover Target: ORAI3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2,6-difluoro-N-[1-[[4-hydroxy-2-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]benzamide
INCHI	InChI=1S/C18H12F5N3O2/c19-13-2-1-3-14(20)16(13)17(28)24-15-6-7-26(25-15)9-10-4-5-11(27)8-12(10)18(21,22)23/h1-8,27H,9H2,(H,24,25,28)
InChi Key	CPYTVBALBFSXSH-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C(=C1)F)C(=O)NC2=NN(C=C2)CC3=C(C=C(C=C3)O)C(F)(F)F)F
Isomeric SMILES	C1=CC(=C(C(=C1)F)C(=O)NC2=NN(C=C2)CC3=C(C=C(C=C3)O)C(F)(F)F)F
PubChem CID	59547990
MeSH Entry Terms	2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide;GSK-7975A
Molecular Weight	397.3

PubChem CID

59547990

CAS Registry No.

1253186-56-9

References

1. Rice LV, Bax HJ, Russell LJ, Barrett VJ, Walton SE, Deakin AM, Thomson SA, Lucas F, Solari R, House D et al.. (2013) Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations.. Eur J Pharmacol, 704 (1-3): (49-57). [PMID:23454522]
2. Wen L, Voronina S, Javed MA, Awais M, Szatmary P, Latawiec D, Chvanov M, Collier D, Huang W, Barrett J et al.. (2015) Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models.. Gastroenterology, 149 (2): (481-92.e7). [PMID:25917787]

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GSK-7975A , CAS No.1253186-56-9, Channel blocker of Orai1;Channel blocker of Orai2

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

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