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GSK-7975A , CAS No.1253186-56-9, Channel blocker of Orai1;Channel blocker of Orai2

  • Moligand™
Item Number
G610729
Grouped product items
SKUSizeAvailabilityPrice Qty
G610729-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
G610729-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
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Orai1 Channel blocker Orai2 Channel blocker

Basic Description

Synonymsexample 36 [US20120053150A1];GSK7975A
Specifications & PurityMoligand™
GradeMoligand™
Action TypeCHANNEL BLOCKER
Mechanism of actionChannel blocker of Orai1;Channel blocker of Orai2

Associated Targets

ORAI1 Tchem Calcium release-activated calcium channel protein 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STIM1 Tbio Stromal interaction molecule 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ORAI2 Tchem Protein orai-2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2,6-difluoro-N-[1-[[4-hydroxy-2-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]benzamide
INCHI InChI=1S/C18H12F5N3O2/c19-13-2-1-3-14(20)16(13)17(28)24-15-6-7-26(25-15)9-10-4-5-11(27)8-12(10)18(21,22)23/h1-8,27H,9H2,(H,24,25,28)
InChi Key CPYTVBALBFSXSH-UHFFFAOYSA-N
Canonical SMILES C1=CC(=C(C(=C1)F)C(=O)NC2=NN(C=C2)CC3=C(C=C(C=C3)O)C(F)(F)F)F
Isomeric SMILES C1=CC(=C(C(=C1)F)C(=O)NC2=NN(C=C2)CC3=C(C=C(C=C3)O)C(F)(F)F)F
PubChem CID 59547990
MeSH Entry Terms 2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide;GSK-7975A
Molecular Weight 397.3

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Rice LV, Bax HJ, Russell LJ, Barrett VJ, Walton SE, Deakin AM, Thomson SA, Lucas F, Solari R, House D et al..  (2013)  Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations..  Eur J Pharmacol,  704  (1-3): (49-57).  [PMID:23454522]
2. Wen L, Voronina S, Javed MA, Awais M, Szatmary P, Latawiec D, Chvanov M, Collier D, Huang W, Barrett J et al..  (2015)  Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models..  Gastroenterology,  149  (2): (481-92.e7).  [PMID:25917787]

Solution Calculators

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