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GSK065 , CAS No.G610682, Inhibitor of kynurenine 3-monooxygenase
Basic Description
| Synonyms | GSK3335065;inhibitor C1 |
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| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Inhibitor of kynurenine 3-monooxygenase |
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Names and Identifiers
| INCHI | InChI=1S/C17H15ClN2O4/c1-10(13-4-2-3-7-19-13)23-16-9-15-11(8-12(16)18)14(20-24-15)5-6-17(21)22/h2-4,7-10H,5-6H2,1H3,(H,21,22)/t10-/m1/s1 |
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| InChi Key | WPAHVUADNLXSOM-SNVBAGLBSA-N |
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| Canonical SMILES | OC(=O)CCc1noc2c1cc(Cl)c(c2)O[C@@H](c1ccccn1)C |
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| Isomeric SMILES | C[C@H](C1=CC=CC=N1)OC2=C(C=C3C(=C2)ON=C3CCC(=O)O)Cl |
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| PubChem CID | 121415134 |
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References
| 1. Skouras C, Zheng X, Binnie M, Homer NZ, Murray TB, Robertson D, Briody L, Paterson F, Spence H, Derr L et al.. (2016) Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis.. Sci Rep, 6 (3): (33951). [PMID:27669975] |
| 2. Hutchinson JP, Rowland P, Taylor MRD, Christodoulou EM, Haslam C, Hobbs CI, Holmes DS, Homes P, Liddle J, Mole DJ et al.. (2017) Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.. Nat Commun, 8 (3): (15827). [PMID:28604669] |
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