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GSK1059615 - ≥98%, high purity , PI3-kinase class I inhibitor, CAS No.958852-01-2, PI3-kinase class I inhibitor

Moligand™
≥98%

CAS#: 958852-01-2
Formula: C₁₈H₁₁N₃O₂S
Molecular Weight: 333.36
PubChem CID: 23582824
PubChem SID: 488200355

Item Number

G127955

Grouped product items
SKU	Size	Availability	Price
G127955-5mg	5mg	In stock	$75.90
G127955-25mg	25mg	In stock	$342.90
G127955-100mg	100mg	In stock	$706.90

Potent PI 3-kinase inhibitor

View related series

phosphatidylinositol-4，5-bisphosphate 3-kinase catalytic subunit alpha Inhibitor

Basic Description

Synonyms	GSK1059615\|958852-01-2\|GSK-1059615\|GSK 1059615\|(Z)-5-((4-(pyridin-4-yl)quinolin-6-yl)methylene)thiazolidine-2,4-dione\|UNII-07YMO87363\|GSK-615\|07YMO87363\|5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione\|(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent inhibitor of PI 3-kinaseα(PI3Kα) (IC50= 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	PI3-kinase class I inhibitor
Product Description	GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. A potent inhibitor of PI 3-kinase and FRAP (mTOR)

Names and Identifiers

Pubchem Sid	488200355
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200355
IUPAC Name	(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
INCHI	InChI=1S/C18H11N3O2S/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,22,23)/b16-10-
InChi Key	QDITZBLZQQZVEE-YBEGLDIGSA-N
Canonical SMILES	C1=CC2=NC=CC(=C2C=C1C=C3C(=O)NC(=O)S3)C4=CC=NC=C4
Isomeric SMILES	C1=CC2=NC=CC(=C2C=C1/C=C\3/C(=O)NC(=O)S3)C4=CC=NC=C4
PubChem CID	23582824
Molecular Weight	333.36

PubChem CID

CAS Registry No.

ChEMBL Ligand

Reactome Reaction

Reactome Drug

PubChem SID

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6 results found

Lot Number	Certificate Type	Date	Item
C2313754	Certificate of Analysis	Dec 09, 2022	G127955
C2313756	Certificate of Analysis	Dec 09, 2022	G127955
C2316751	Certificate of Analysis	Dec 09, 2022	G127955
C2316753	Certificate of Analysis	Dec 09, 2022	G127955
C2316755	Certificate of Analysis	Dec 09, 2022	G127955
C2316762	Certificate of Analysis	Dec 09, 2022	G127955

Solubility

Solvent:DMSO, Max Conc. mg/mL: 3.33, Max Conc. mM: 10

Refractive Index

1.76

References

1. Xie J, Li Q, Ding X, Gao Y. (2017) GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway.. Oncotarget, 8 (31): (50814-50823). [PMID:28881606]
2. Knight SD, Adams ND, Burgess JL, Chaudhari AM, Darcy MG, Donatelli CA, Luengo JI, Newlander KA, Parrish CA, Ridgers LH et al.. (2010) Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.. ACS Med Chem Lett, 1 (1): (39-43). [PMID:24900173]

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GSK1059615 - ≥98%, high purity , PI3-kinase class I inhibitor, CAS No.958852-01-2, PI3-kinase class I inhibitor

Basic Description

Product Properties

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Certificates

Certificate of Analysis(COA)

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References

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