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GSK2292767 - 10mM in DMSO, high purity , CAS No.1254036-66-2
p110δ Selective Inhibitors
Basic Description Synonyms GSK2292767 | 1254036-66-2 | GSK-2292767 | 4M4E8NZ73C | Methanesulfonamide, N-[5-[4-[5-[[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-methoxy-3-pyridinyl]-, rel- | CHEMBL4434674 | PI3Kdelta inhibitor GS2292767 | n-[5-[4-(5-{[(2r,6s)-2,6-dime Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms GSK2292767 is a potent and selective PI3Kδ inhibitor. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description Information
GSK2292767 is a potent and selectivePI3Kδinhibitor.
Targets
PI3Kδ
In vivo
GSK2292767 is highly selective for PI3Kδ over the closely related isoforms and is active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name N-[5-[4-[5-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl]-1,3-oxazol-2-yl]-1H-indazol-6-yl]-2-methoxypyridin-3-yl]methanesulfonamide INCHI InChI=1S/C24H28N6O5S/c1-14-11-30(12-15(2)34-14)13-18-9-26-23(35-18)19-5-16(6-21-20(19)10-27-28-21)17-7-22(29-36(4,31)32)24(33-3)25-8-17/h5-10,14-15,29H,11-13H2,1-4H3,(H,27,28)/t14-,15+ InChi Key NLUPPCTVKHDVIQ-GASCZTMLSA-N Canonical SMILES CC1CN(CC(O1)C)CC2=CN=C(O2)C3=C4C=NNC4=CC(=C3)C5=CC(=C(N=C5)OC)NS(=O)(=O)C Isomeric SMILES C[C@@H]1CN(C[C@@H](O1)C)CC2=CN=C(O2)C3=C4C=NNC4=CC(=C3)C5=CC(=C(N=C5)OC)NS(=O)(=O)C PubChem CID 49783923 Molecular Weight 512.58
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