GSK2334470 - 95%, high purity , CAS No.1227911-45-6, Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of aurora kinase A;Inhibitor of aurora kinase B
GSK2334470 - 95%, high purity , CAS No.1227911-45-6, Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of aurora kinase A;Inhibitor of aurora kinase B
GSK2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1). GSK2334470 can be used in cells to ablate T-loop phosphorylation and activate SGK, S6K1 and RSK as well as suppress the activation of Akt.Novel,
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of aurora kinase A;Inhibitor of aurora kinase B
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases. A potent and selective PDK1 inhibitor that subsequently induces apoptotic cell death
1.Shiojima I, Walsh K. (2002) Role of Akt signaling in vascular homeostasis and angiogenesis.. Circ Res, 90 (12):(1243-50). [PMID:12089061]
2.Hanada M, Feng J, Hemmings BA. (2004) Structure, regulation and function of PKB/AKT--a major therapeutic target.. Biochim Biophys Acta, 1697 (1-2):(3-16). [PMID:15023346]
3.Medina JR, Becker CJ, Blackledge CW, Duquenne C, Feng Y, Grant SW, Heerding D, Li WH, Miller WH, Romeril SP et al.. (2011) Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.. J Med Chem, 54 (6):(1871-95). [PMID:21341675]
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