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GSK256066 - ≥98%, high purity , Phosphodiesterase 4 inhibitor, CAS No.801312-28-7, Phosphodiesterase 4 inhibitor
Basic Description Synonyms DTXSID30230090 | AC-32928 | Histidine-Alanine dipeptide | MFCD18206923 | MLS006011116 | 6-[3-(Dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide | SMR004702897 | NCGC00346620-06 | C27H26N4O5S | NCGC00346620-08 | SCHEMBL Specifications & Purity ≥98% Biochemical and Physiological Mechanisms GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFα production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type INHIBITOR Mechanism of action Phosphodiesterase 4 inhibitor Product Description GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 6-[3-(dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide INCHI InChI=1S/C27H26N4O5S/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H,1-4H3,(H2,28,32)(H,29,30) InChi Key JFHROPTYMMSOLG-UHFFFAOYSA-N Canonical SMILES CC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C Isomeric SMILES CC1=CC(=CC2=C(C(=CN=C12)C(=O)N)NC3=CC(=CC=C3)OC)S(=O)(=O)C4=CC=CC(=C4)C(=O)N(C)C PubChem CID 9827968 Molecular Weight 518.58
Chemical and Physical Properties Solubility DMSO 5 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS08 , GHS07 Signal Danger Hazard Statements H335: May cause respiratory irritation
H373: Causes damage to organs through prolonged or repeated exposure
H330: Fatal if inhaled
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P405: Store locked up.
P501: Dispose of contents/container to ...
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P284: [In case of inadequate ventilation] Wear respiratory protection.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P320: Specific treatment is urgent (see ... on this label).
P316: Get emergency medical help immediately.
P319: Get medical help if you feel unwell.
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