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GSK2603566A , CAS No.G610706, Antagonist of integrin αVβ3

PubChem CID: 139593557

Item Number

G610706

Grouped product items
SKU	Size	Availability	Price	Qty
G610706-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
G610706-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

integrin αVβ3 Antagonist

Synonyms

compound 39

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Antagonist of integrin αVβ3

Associated Targets(Human)

ITGB3 Tclin Integrin beta-3 (0 Activities)

Discover Target: ITGB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGAV Tchem Integrin alpha-V (0 Activities)

Discover Target: ITGAV

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGB3 Tclin Integrin alpha-V/beta-3 (2708 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	3-(3-Cyclopropylphenyl)-3-((5-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy)pyridin-2-yl)amino)propanoic acid
INCHI	InChI=1S/C27H30N4O3/c32-26(33)16-24(21-4-1-3-20(15-21)18-6-7-18)31-25-11-10-23(17-29-25)34-14-12-22-9-8-19-5-2-13-28-27(19)30-22/h1,3-4,8-11,15,17-18,24H,2,5-7,12-14,16H2,(H,28,30)(H,29,31)(H,32,33)
InChi Key	APVMUACUMAKXLA-UHFFFAOYSA-N
Canonical SMILES	OC(=O)CC(c1cccc(c1)C1CC1)Nc1ccc(cn1)OCCc1ccc2c(n1)NCCC2
Isomeric SMILES	C1CC2=C(NC1)N=C(C=C2)CCOC3=CN=C(C=C3)NC(CC(=O)O)C4=CC=CC(=C4)C5CC5
PubChem CID	139593557

References

1. Anderson NA, Campos S, Butler S, Copley RCB, Duncan I, Harrison S, Le J, Maghames R, Pastor-Garcia A, Pritchard JM et al.. (2019) Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.. J Med Chem, 62 (19): (8796-8808). [PMID:31497959] [10.1021/op500134e]

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GSK2603566A , CAS No.G610706, Antagonist of integrin αVβ3

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

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