GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC 50 of 7.1. GSK2646264 also inhibits other kinases with pIC 50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK , LRRK2 , GSK3β , JAK2 , VEGFR2 ,
Storage Temp
Protected from light,Store at -80°C
Shipped In
Ice chest + Ice pads
Product Description
GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC 50 of 7.1. GSK2646264 also inhibits other kinases with pIC 50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK , LRRK2 , GSK3β , JAK2 , VEGFR2 , Aurora B and Aurora A , respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin
In Vitro
GSK2646264 (0.01-10 μM; 1 h) significantly inhibits anti‐IgE (but not C5a)‐induced histamine release from skin mast cells in a concentration‐dependent manner. The IC 50 is 0.7 μM and the IC 90 is 6.8 μM. GSK2646264 cream (0.5, 1, and 3% [wt/wt]; 1 cm 2 ; 4 and 24 h) inhibits anti‐IgE‐induced histamine release from mast cells in ex vivo human skin. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
