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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G276179-5mg | 5mg | In stock | $46.90 | |
G276179-25mg | 25mg | In stock | $195.90 | |
G276179-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $325.90 | |
G276179-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $587.90 | |
G276179-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,323.90 |
Potent and selective PERK inhibitor
Synonyms | GSK2656157|1337532-29-2|GSK-2656157|1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone|CHEMBL2441340|SCHEMBL870782|PERK inhibitor GSK2656157|1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4- |
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Specifications & Purity | ≥98% |
Storage Temp | Store at -20°C |
Shipped In | Dry ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 3 |
Product Description | Shipped at room temperature. Store at -20°C. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone |
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INCHI | InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27) |
InChi Key | PRWSIEBRGXYXAJ-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=NC=NC(=C45)N)C |
Isomeric SMILES | CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=NC=NC(=C45)N)C |
Alternate CAS | 1337532-29-2 |
PubChem CID | 53469059 |
MeSH Entry Terms | GSK2656157 |
Molecular Weight | 416.45 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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I2202505 | Certificate of Analysis | Jun 13, 2023 | G276179 |
I2202506 | Certificate of Analysis | Jun 13, 2023 | G276179 |
I2202516 | Certificate of Analysis | Jun 13, 2023 | G276179 |
I2202497 | Certificate of Analysis | Jun 13, 2023 | G276179 |
I2202438 | Certificate of Analysis | Jun 12, 2023 | G276179 |
Solubility | Soluble in DMSO to 50 mM |
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1. Atkins C, Liu Q, Minthorn E, Zhang SY, Figueroa DJ, Moss K, Stanley TB, Sanders B, Goetz A, Gaul N et al.. (2013) Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity.. Cancer Res, 73 (6): (1993-2002). [PMID:23333938] |