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GSK2656157 - ≥98%, high purity , CAS No.1337532-29-2, Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 3

  • Moligand™
  • ≥98%
Item Number
G276179
Grouped product items
SKUSizeAvailabilityPrice Qty
G276179-5mg
5mg
In stock
$46.90
G276179-25mg
25mg
In stock
$195.90
G276179-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$325.90
G276179-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$587.90
G276179-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,323.90

Potent and selective PERK inhibitor

Basic Description

SynonymsGSK2656157|1337532-29-2|GSK-2656157|1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethanone|CHEMBL2441340|SCHEMBL870782|PERK inhibitor GSK2656157|1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InDry ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of eukaryotic translation initiation factor 2 alpha kinase 3
Product Description

Shipped at room temperature. Store at -20°C.

Associated Targets

EIF2AK3 Tchem Eukaryotic translation initiation factor 2-alpha kinase 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
INCHI InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)
InChi Key PRWSIEBRGXYXAJ-UHFFFAOYSA-N
Canonical SMILES CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=NC=NC(=C45)N)C
Isomeric SMILES CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=NC=NC(=C45)N)C
Alternate CAS 1337532-29-2
PubChem CID 53469059
MeSH Entry Terms GSK2656157
Molecular Weight 416.45

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
I2202505Certificate of AnalysisJun 13, 2023 G276179
I2202506Certificate of AnalysisJun 13, 2023 G276179
I2202516Certificate of AnalysisJun 13, 2023 G276179
I2202497Certificate of AnalysisJun 13, 2023 G276179
I2202438Certificate of AnalysisJun 12, 2023 G276179

Chemical and Physical Properties

SolubilitySoluble in DMSO to 50 mM

Related Documents

References

1. Atkins C, Liu Q, Minthorn E, Zhang SY, Figueroa DJ, Moss K, Stanley TB, Sanders B, Goetz A, Gaul N et al..  (2013)  Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity..  Cancer Res,  73  (6): (1993-2002).  [PMID:23333938]

Solution Calculators