GSK3β inhibitor II - ≥95%, high purity , CAS No.478482-75-6, Inhibitor of glycogen synthase kinase 3 beta

Item Number

G338641

• Synonyms: 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole | 2-{[(3-iodophenyl)methyl]sulfanyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole | Pyridine, 4-[5-[[(3-iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]- | SCHEMBL5022122 | K00026 | 4-(5-{[(3-iodophenyl)methyl]sulfa
• Specifications & Purity: Moligand™, ≥95%
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of glycogen synthase kinase 3 beta

Product Description

GSK-3 Inhibitor II is a potent inhibitor of GSK-3β (glycogen synthase kinase-3β) (IC|50|=390 nM). GSK-3 was first discovered to be involved in the control of glycogen metabolism, but has since been indicated in regulating a diverse range of cellular functions, such as neuronal cell survival and death. GSK-3β plays an important role in cardiomyopathies and has been shown to decrease MRP2 expression in neuronal growth factor (NGF)-induced PC-12 cells . Activation of GSK-3β plays a critical role in diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling.