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GSK461364 - 98% , high purity , Serine/threonine-protein kinase PLK1 inhibitor, CAS No.929095-18-1, Serine/threonine-protein kinase PLK1 inhibitor
Basic Description Synonyms 929095-18-1|GSK461364|GSK-461364|GSK 461364|GSK-461364A|(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide|GSK461364A|UNII-8QO27TK6Q4|8QO27TK6Q4|5-[6-[(4-Methyl-1-piperazinyl) Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms GSK-461364A is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM. GSK-461364A is an ATP-competitive inhibitor of Plk1 and forms a rapidly reversible complex with Plk1.GSK461364 is an imidazotriazine derivate
Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Serine/threonine-protein kinase PLK1 inhibitor
Names and Identifiers IUPAC Name 5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide INCHI InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 InChi Key ZHJGWYRLJUCMRT-QGZVFWFLSA-N Canonical SMILES CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N Isomeric SMILES C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N PubChem CID 15983966 Molecular Weight 543.62
Chemical and Physical Properties Solubility DMSO 10 mg/mL Water <1 mg/mL Ethanol 30 mg/mL Sensitivity Moisture sensitive.
References 1. Gilmartin AG, Bleam MR, Richter MC, Erskine SG, Kruger RG, Madden L, Hassler DF, Smith GK, Gontarek RR, Courtney MP et al. . (2009) Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis.. Cancer Res, 69 (17): (6969-77). [PMID:19690138 ]
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L2118049