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GSK503 - 98%, high purity , CAS No.1346572-63-1

≥98%

CAS#: 1346572-63-1
Formula: C₃₁H₃₈N₆O₂
Molecular Weight: 526.67
PubChem CID: 67469117

Item Number

G276508

Grouped product items
SKU	Size	Availability	Price
G276508-5mg	5mg	In stock	$88.90
G276508-10mg	10mg	In stock	$137.90
G276508-25mg	25mg	In stock	$310.90
G276508-50mg	50mg	In stock	$484.90
G276508-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$771.90

Potent and specific EZH2 methyltransferase inhibitor

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent (IC 50 = nM; K i = 3 nM)\xa0and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC 50 = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a\xa0range of human histone
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Shipped at room temperature. Store at -20°C.

Associated Targets(Human)

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 (4 Activities)

Discover Target: EZH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 (2012 Activities)

Discover Target: EZH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindole-4-carboxamide
INCHI	InChI=1S/C31H38N6O2/c1-19(2)37-18-21(4)29-25(30(38)33-17-26-20(3)13-22(5)34-31(26)39)14-24(15-27(29)37)23-7-8-28(32-16-23)36-11-9-35(6)10-12-36/h7-8,13-16,18-19H,9-12,17H2,1-6H3,(H,33,38)(H,34,39)
InChi Key	HRDQQHUKUIKFHT-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C(=CN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C)C)C
Isomeric SMILES	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C(=CN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C)C)C
PubChem CID	67469117
Molecular Weight	526.67

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
L2129134	Certificate of Analysis	Jul 12, 2023	G276508
L2129135	Certificate of Analysis	Jul 12, 2023	G276508
L2129136	Certificate of Analysis	Jul 12, 2023	G276508
L2129137	Certificate of Analysis	Jul 12, 2023	G276508
L2129138	Certificate of Analysis	Jul 12, 2023	G276508

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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