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GT 949 - 96%, high purity , CAS No.460330-27-2
Potent and selective positive allosteric modulator of EAAT2
Basic Description Specifications & Purity ≥96% Biochemical and Physiological Mechanisms GT949 is a potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2 (glutamate uptake EC50 = 0.26 nM; COS-7 EAAT2 transfectant), but not EAAT1 or EAAT3. GT949 enhances glutamate uptake of cultured rat astrocy Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-[(4-cyclohexylpiperazin-1-yl)-[1-(2-phenylethyl)tetrazol-5-yl]methyl]-6-methoxy-1H-quinolin-2-one INCHI InChI=1S/C30H37N7O2/c1-39-25-12-13-27-23(20-25)21-26(30(38)31-27)28(36-18-16-35(17-19-36)24-10-6-3-7-11-24)29-32-33-34-37(29)15-14-22-8-4-2-5-9-22/h2,4-5,8-9,12-13,20-21,24,28H,3,6-7,10-11,14-19H2,1H3,(H,31,38) InChi Key ZVWPOIUAPXDLMB-UHFFFAOYSA-N Canonical SMILES COC1=CC2=C(C=C1)NC(=O)C(=C2)C(C3=NN=NN3CCC4=CC=CC=C4)N5CCN(CC5)C6CCCCC6 Isomeric SMILES COC1=CC2=C(C=C1)NC(=O)C(=C2)C(C3=NN=NN3CCC4=CC=CC=C4)N5CCN(CC5)C6CCCCC6 PubChem CID 3195790 Molecular Weight 527.66
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 52.77, Max Conc. mM: 100
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B23271175