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Guanosine 3′,5′-cyclic monophosphate - ≥98%, high purity , CAS No.7665-99-8, Activator of CNGA1;Activator of CNGA2;Activator of CNGA3;Activator of HCN2;Activator of phosphodiesterase 2A;Inhibitor of phosphodiesterase 3A;Inhibitor of phosphodiesterase 3B

  • Moligand™
  • ≥98%
Item Number
G349525
Grouped product items
SKUSizeAvailabilityPrice Qty
G349525-5mg
5mg
In stock
$43.90
G349525-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$155.90

an important second messenger

Basic Description

Synonymscyclic gmp|cGMP|7665-99-8|3',5'-cyclic GMP|Cyclic guanosine monophosphate|Guanosine cyclic monophosphate|Guanosine 3',5'-monophosphate|guanosine 3',5'-cyclic phosphate|Cyclic 3',5'-GMP|Guanosine 3',5'-cyclic monophosphate|CHEBI:16356|cyclic-GMP|UNII-H2D2X
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR, INHIBITOR
Mechanism of actionActivator of CNGA1;Activator of CNGA2;Activator of CNGA3;Activator of HCN2;Activator of phosphodiesterase 2A;Inhibitor of phosphodiesterase 3A;Inhibitor of phosphodiesterase 3B
Product Description

Guanosine 3',5'-cyclic monophosphate is an important second messenger which is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases.

Associated Targets

CNGA3 Tchem Cyclic nucleotide-gated cation channel alpha-3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC22A6 Tclin Solute carrier family 22 member 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC22A7 Tbio Solute carrier family 22 member 7 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDE3B Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDE2A Tclin cGMP-dependent 3',5'-cyclic phosphodiesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABCC5 Tchem Multidrug resistance-associated protein 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABCC4 Tchem Multidrug resistance-associated protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CNGA1 Tchem cGMP-gated cation channel alpha-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CNGA2 Tchem Cyclic nucleotide-gated olfactory channel 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABCC11 Tbio ATP-binding cassette sub-family C member 11 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HCN2 Tclin Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-1H-purin-6-one
INCHI InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
InChi Key ZOOGRGPOEVQQDX-UUOKFMHZSA-N
Canonical SMILES C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(O1)O
Isomeric SMILES C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(O1)O
WGK Germany 3
PubChem CID 135398570
Molecular Weight 345.21

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
K2212656Certificate of AnalysisOct 24, 2022 G349525
K2212672Certificate of AnalysisOct 24, 2022 G349525

Chemical and Physical Properties

Solubility50 mg/mL of 1% sodium bicarbonate
SensitivityMoisture sensitive
Boil Point(°C)480.00° C (Predicted)
Melt Point(°C)90.27° C (Predicted)

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RIDADR NONHforallmodesoftransport

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