Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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G349525-5mg | 5mg | In stock | $43.90 | |
G349525-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $155.90 |
an important second messenger
Synonyms | 3',5'-cGMP | 35G | cyclic gmp | EINECS 231-641-6 | 2-amino-9-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one | Cyclic guanosine 3',5'-monophosphate | Epitope ID:149170 | GMP, Cyclic |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR, INHIBITOR |
Mechanism of action | Activator of CNGA1;Activator of CNGA2;Activator of CNGA3;Activator of HCN2;Activator of phosphodiesterase 2A;Inhibitor of phosphodiesterase 3A;Inhibitor of phosphodiesterase 3B |
Product Description | Guanosine 3',5'-cyclic monophosphate is an important second messenger which is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-1H-purin-6-one |
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INCHI | InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1 |
InChi Key | ZOOGRGPOEVQQDX-UUOKFMHZSA-N |
Canonical SMILES | C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(O1)O |
Isomeric SMILES | C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(O1)O |
WGK Germany | 3 |
PubChem CID | 135398570 |
Molecular Weight | 345.21 |
PubChem CID | 135398570 |
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Wikipedia | Cyclic_guanosine_monophosphate |
ChEBI | CHEBI:16356 |
CAS Registry No. | 7665-99-8 |
ChEMBL Ligand | CHEMBL395336 |
RCSB PDB Ligand | 35G, PCG |
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Solubility | 50 mg/mL of 1% sodium bicarbonate |
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Sensitivity | Moisture sensitive |
Boil Point(°C) | 480.00° C (Predicted) |
Melt Point(°C) | 90.27° C (Predicted) |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RIDADR | NONHforallmodesoftransport |