Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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G276180-2mg | 2mg | In stock | $36.90 | |
G276180-5mg | 5mg | In stock | $75.90 | |
G276180-10mg | 10mg | In stock | $140.90 | |
G276180-50mg | 50mg | In stock | $434.90 | |
G276180-100mg | 100mg | In stock | $761.90 |
Broad spectrum steroid receptor antagonist
Synonyms | AVQFHKYAVVQYQO-UHFFFAOYSA- | 6CST3U34GN | GUGGULSTERONE Z [USP-RS] | NCGC00260067-01 | Z/E-Guggulsterone | AC-28813 | CHEBI:135338 | Guggulsterones Z | 2-(2-Aminothiazol-3(2H)-yl)-1-phenylethanone | Guggulsterone | AC-6215 | Q27264514 | (17Z)-Guggulsteron |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Broad spectrum steroid receptor antagonist (K i values are 39, 224 and 240 nM for mineralocorticoid, glucocorticoid and androgen receptors respectively). Partial progesterone receptor agonist (K i = 201 nM). Shows hypoglycemic and hypolipidemic effects in |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of Farnesoid X receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione |
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INCHI | InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1 |
InChi Key | WDXRGPWQVHZTQJ-OSJVMJFVSA-N |
Canonical SMILES | CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C |
Isomeric SMILES | C/C=C/1\C(=O)C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C |
PubChem CID | 6450278 |
Molecular Weight | 312.45 |
PubChem CID | 6439929 |
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BindingDB Ligand | 50226465 |
Wikipedia | Guggulsterone |
CAS Registry No. | 95975-55-6 |
ChEMBL Ligand | CHEMBL402063 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K2218700 | Certificate of Analysis | Sep 15, 2023 | G276180 |
K2218771 | Certificate of Analysis | Sep 15, 2023 | G276180 |
K2218776 | Certificate of Analysis | Sep 15, 2023 | G276180 |
K2218866 | Certificate of Analysis | Sep 15, 2023 | G276180 |
K2218867 | Certificate of Analysis | Sep 15, 2023 | G276180 |
Solubility | insoluble in ethanol,DMSO: 62 mg/mL (198.43 mM) |
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Sensitivity | Light sensitive |
Melt Point(°C) | >141°C (dec.) |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P264:Wash hands [and …] thoroughly after handling. P362+P364:Take off contaminated clothing and wash it before reuse. P332+P317:If skin irritation occurs: Get medical help. |